What is the optimal anodal electrode position for inducing corticomotor excitability changes in transcranial direct current stimulation?

Minji Lee, Yun Hee Kim, Chang Hwan Im, Jung Hoon Kim, Chang hyun Park, Won Hyuk Chang, Ahee Lee

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Transcranial direct current stimulation (tDCS) non-invasively modulates brain function by inducing neuronal excitability. The conventional hot spot for inducing the highest current density in the hand motor area may not be the optimal site for effective stimulation. In this study, we investigated the influence of the center position of the anodal electrode on changes in motor cortical excitability. We considered three tDCS conditions in 16 healthy subjects: (i) real stimulation with the anodal electrode located at the conventional hand motor hot spot determined by motor evoked potentials (MEPs); (ii) real stimulation with the anodal electrode located at the point with the highest current density in the hand motor area as determined by electric current simulation; and (iii) sham stimulation. Motor cortical excitability as measured by MEP amplitude increased after both real stimulation conditions, but not after sham stimulation. Stimulation using the simulation-derived anodal electrode position, which was found to be posterior to the MEP hot spot for all subjects, induced higher motor cortical excitability. Individual positioning of the anodal electrode, based on the consideration of anatomical differences between subjects, appears to be important for maximizing the effects of tDCS.

Original languageEnglish
Pages (from-to)347-350
Number of pages4
JournalNeuroscience Letters
Volume584
DOIs
StatePublished - 2015 Jan 1

Keywords

  • Electric current density
  • Motor cortical excitability
  • Transcranial direct current stimulation (tDCS)

Fingerprint Dive into the research topics of 'What is the optimal anodal electrode position for inducing corticomotor excitability changes in transcranial direct current stimulation?'. Together they form a unique fingerprint.

  • Cite this