Visceral Obesity Predicts Fewer Lymph Node Metastases and Better Overall Survival in Colon Cancer

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18 Citations (Scopus)

Abstract

Background: The relationship between visceral obesity and colon cancer outcome has not been well studied. The goal of this study was to determine the impact of visceral obesity on lymph node (LN) metastasis and overall survival (OS) in colon cancer. Materials and Methods: Metastatic LN ratio (MLR) was defined as the number of involved nodes by tumor divided by the total number of resected LNs. Visceral (VFA) and subcutaneous fat areas (SFA) were determined by measuring abdominal fat volume distribution via CT scan, and visceral obesity was defined as a VFA to total fat area ratio (V/T) > 0.29. Results: In a multivariate analysis among 186 patients, there were inverse associations between V/T and MLR (OR = 0.413, 95 % CI = 0.216–0.789, P = 0.007). Furthermore, patients with visceral obesity tended to have significantly better OS than patients with non-visceral obesity. Conclusions: Higher V/T ratios which indicate referring to visceral obesity was significantly associated with decreased MLR and better OS for CRC.

Original languageEnglish
Pages (from-to)1513-1521
Number of pages9
JournalJournal of Gastrointestinal Surgery
Volume19
Issue number8
DOIs
StatePublished - 2015 Aug 25

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Abdominal Obesity
Colonic Neoplasms
Lymph Nodes
Neoplasm Metastasis
Survival
Abdominal Fat
Intra-Abdominal Fat
Subcutaneous Fat
Multivariate Analysis
Obesity
Fats
Neoplasms

Keywords

  • Colon cancer
  • Lymph node
  • Metastasis
  • Obesity
  • Visceral fat area

Cite this

@article{9aa4ab446be243c0a502623eedad9d5c,
title = "Visceral Obesity Predicts Fewer Lymph Node Metastases and Better Overall Survival in Colon Cancer",
abstract = "Background: The relationship between visceral obesity and colon cancer outcome has not been well studied. The goal of this study was to determine the impact of visceral obesity on lymph node (LN) metastasis and overall survival (OS) in colon cancer. Materials and Methods: Metastatic LN ratio (MLR) was defined as the number of involved nodes by tumor divided by the total number of resected LNs. Visceral (VFA) and subcutaneous fat areas (SFA) were determined by measuring abdominal fat volume distribution via CT scan, and visceral obesity was defined as a VFA to total fat area ratio (V/T) > 0.29. Results: In a multivariate analysis among 186 patients, there were inverse associations between V/T and MLR (OR = 0.413, 95 {\%} CI = 0.216–0.789, P = 0.007). Furthermore, patients with visceral obesity tended to have significantly better OS than patients with non-visceral obesity. Conclusions: Higher V/T ratios which indicate referring to visceral obesity was significantly associated with decreased MLR and better OS for CRC.",
keywords = "Colon cancer, Lymph node, Metastasis, Obesity, Visceral fat area",
author = "Park, {Se Woo} and Lee, {Hang Lak} and Doo, {Eun Young} and Lee, {Kang Nyeong} and Jung, {Dae Won} and Lee, {Oh Young} and Han, {Dong Soo} and Yoon, {Byung Chul} and Choi, {Ho Soon} and Lee, {Kang Hong}",
year = "2015",
month = "8",
day = "25",
doi = "10.1007/s11605-015-2834-z",
language = "English",
volume = "19",
pages = "1513--1521",
journal = "Journal of Gastrointestinal Surgery",
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}

TY - JOUR

T1 - Visceral Obesity Predicts Fewer Lymph Node Metastases and Better Overall Survival in Colon Cancer

AU - Park, Se Woo

AU - Lee, Hang Lak

AU - Doo, Eun Young

AU - Lee, Kang Nyeong

AU - Jung, Dae Won

AU - Lee, Oh Young

AU - Han, Dong Soo

AU - Yoon, Byung Chul

AU - Choi, Ho Soon

AU - Lee, Kang Hong

PY - 2015/8/25

Y1 - 2015/8/25

N2 - Background: The relationship between visceral obesity and colon cancer outcome has not been well studied. The goal of this study was to determine the impact of visceral obesity on lymph node (LN) metastasis and overall survival (OS) in colon cancer. Materials and Methods: Metastatic LN ratio (MLR) was defined as the number of involved nodes by tumor divided by the total number of resected LNs. Visceral (VFA) and subcutaneous fat areas (SFA) were determined by measuring abdominal fat volume distribution via CT scan, and visceral obesity was defined as a VFA to total fat area ratio (V/T) > 0.29. Results: In a multivariate analysis among 186 patients, there were inverse associations between V/T and MLR (OR = 0.413, 95 % CI = 0.216–0.789, P = 0.007). Furthermore, patients with visceral obesity tended to have significantly better OS than patients with non-visceral obesity. Conclusions: Higher V/T ratios which indicate referring to visceral obesity was significantly associated with decreased MLR and better OS for CRC.

AB - Background: The relationship between visceral obesity and colon cancer outcome has not been well studied. The goal of this study was to determine the impact of visceral obesity on lymph node (LN) metastasis and overall survival (OS) in colon cancer. Materials and Methods: Metastatic LN ratio (MLR) was defined as the number of involved nodes by tumor divided by the total number of resected LNs. Visceral (VFA) and subcutaneous fat areas (SFA) were determined by measuring abdominal fat volume distribution via CT scan, and visceral obesity was defined as a VFA to total fat area ratio (V/T) > 0.29. Results: In a multivariate analysis among 186 patients, there were inverse associations between V/T and MLR (OR = 0.413, 95 % CI = 0.216–0.789, P = 0.007). Furthermore, patients with visceral obesity tended to have significantly better OS than patients with non-visceral obesity. Conclusions: Higher V/T ratios which indicate referring to visceral obesity was significantly associated with decreased MLR and better OS for CRC.

KW - Colon cancer

KW - Lymph node

KW - Metastasis

KW - Obesity

KW - Visceral fat area

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