Tumor necrosis and complete resection has significant impacts on survival in patients with limited-stage upper aerodigestive tract NK/T cell lymphoma

Moo Kon Song, Joo Seop Chung, Ho Young Yhim, Sung Nam Lim, Seong Jang Kim, Yeon Hee Han, Hye Kyung Shim, Sung Hoon Jung, Je Jung Lee, Deok Hwan Yang

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Tumor necrosis (TN) is associated with worse prognosis in several solid cancers. Whether TN predicts poor outcome in natural killer cell/T cell lymphoma (NKTCL) is unclear. We investigated the clinical impact of TN on survival and other novel prognostic parameters in upper aero-digestive tract (UAT) NKTCL of 100 patients with limited stage. TN was significantly associated with poor performance status (p = 0.049), high Korean Prognostic Index score (p = 0.024), high C-reactive protein/albumin ratio (p = 0.003), higher maximum standard uptake value on positron emission tomography/computed tomography (PET/CT) (p = 0.008) and higher metabolic tumor volume (MTV) on PET/CT (p < 0.001). In univariate and multivariate analyses, progression-free survival and overall survival were independently associated with High MTV status (p = 0.001, p = 0.032), TN (p = 0.018, p = 0.009), local tumor invasiveness (p = 0.007, p = 0.035), complete resection (p = 0.020, p = 0.028) and regional lymph node involvement (p < 0.001, p < 0.001). TN and complete resection are concluded to be novel independent prognostic factors in patients with UAT NKTCL.

Original languageEnglish
Pages (from-to)79337-79346
Number of pages10
JournalOncotarget
Volume8
Issue number45
DOIs
StatePublished - 2017 Jan 1

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T-Cell Lymphoma
Natural Killer Cells
Necrosis
Survival
Neoplasms
Tumor Burden
Gastrointestinal Tract
C-Reactive Protein
Disease-Free Survival
Albumins
Multivariate Analysis
Lymph Nodes

Keywords

  • Complete resection
  • Extranodal natural killer/T-cell lymphoma
  • Prognosis
  • Tumor necrosis

Cite this

Song, Moo Kon ; Chung, Joo Seop ; Yhim, Ho Young ; Lim, Sung Nam ; Kim, Seong Jang ; Han, Yeon Hee ; Shim, Hye Kyung ; Jung, Sung Hoon ; Lee, Je Jung ; Yang, Deok Hwan. / Tumor necrosis and complete resection has significant impacts on survival in patients with limited-stage upper aerodigestive tract NK/T cell lymphoma. In: Oncotarget. 2017 ; Vol. 8, No. 45. pp. 79337-79346.
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Tumor necrosis and complete resection has significant impacts on survival in patients with limited-stage upper aerodigestive tract NK/T cell lymphoma. / Song, Moo Kon; Chung, Joo Seop; Yhim, Ho Young; Lim, Sung Nam; Kim, Seong Jang; Han, Yeon Hee; Shim, Hye Kyung; Jung, Sung Hoon; Lee, Je Jung; Yang, Deok Hwan.

In: Oncotarget, Vol. 8, No. 45, 01.01.2017, p. 79337-79346.

Research output: Contribution to journalArticle

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AU - Song, Moo Kon

AU - Chung, Joo Seop

AU - Yhim, Ho Young

AU - Lim, Sung Nam

AU - Kim, Seong Jang

AU - Han, Yeon Hee

AU - Shim, Hye Kyung

AU - Jung, Sung Hoon

AU - Lee, Je Jung

AU - Yang, Deok Hwan

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