Transition-metal-catalyzedortho-selective C-H functionalization reactions of free phenols

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2 Scopus citations


Phenols are important readily available chemical feedstocks and versatile synthetic building blocks for diverse synthetic transformations. Their motifs are prevalent in a diverse array of natural products, pharmaceuticals, functional materials, and privileged chiral ligands. Consequently, the development of facile and direct site-selective C-H bond functionalization of free phenols is of great importance and considerable interest to both industry and academic research. Over the past decades, transition-metal-catalyzed C-H bond functionalization has become as a powerful synthetic tool in organic synthesis. In this review, we provide a brief overview of recent progress in the transition-metal-catalyzed directortho-selective C-H functionalization of free phenols.

Original languageEnglish
Pages (from-to)5028-5047
Number of pages20
JournalOrganic and Biomolecular Chemistry
Issue number23
StatePublished - 2021 Jun 21


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