The usefulness of the status of extranodal tumor extension as a factor that can predict the recurrence of stage III colorectal cancer

Sang Hoon Lee, Hyunsung Kim, Seung Sam Paik, Won Moo Lee, Kang Hong Lee, Byungkyu Ahn

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Abstract

Background: Extranodal tumor extension (ENTE) is considered a poor prognostic factor in colorectal cancer (CRC). This study aimed to investigate the risk factors for recurrence according to ENTE status in stage III CRC. Methods: We retrospectively evaluated 169 consecutive stage III CRC patients. All patients underwent a curative resection between 2005 and 2010. The presence or absence of ENTE was assessed in the resected lymph nodes. Results: ENTE was observed in 65 (38.5%). Recurrence occurred in 38 patients (22.5%) and was more frequent (p =.041) in the ENTE (+) group. Disease-free survival (p =.016) was significantly shorter in the ENTE (+) group than in the ENTE (−) group. In a univariable analysis, recurrence was associated with vascular invasion (p =.006), perforation (p =.024) in the ENTE (−) group and perforation (p =.048) in the ENTE (+) group. In a Cox’s regression test, vascular invasion (p =.014) and the higher ratio of metastatic lymph nodes/total removed lymph nodes (MLN/TLN) (0.009) in the ENTE (−) group and perforation (p =.025) in the ENTE (+) group were independent risk factors of recurrence. Conclusions: Vascular invasion and the higher ratio of MLN/TLN in ENTE (−) patients and perforation in ENTE (+) patients were independent risk factors of recurrence.

Original languageEnglish
Pages (from-to)384-389
Number of pages6
JournalActa Chirurgica Belgica
Volume119
Issue number6
DOIs
StatePublished - 2019 Nov 2

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Colorectal Neoplasms
Recurrence
Neoplasms
Lymph Nodes
Blood Vessels
Disease-Free Survival

Keywords

  • Extranodal tumor extension
  • colorectal cancer
  • perforation
  • recurrence
  • vascular invasion

Cite this

@article{a9caf35b97e74019afe661704b3887af,
title = "The usefulness of the status of extranodal tumor extension as a factor that can predict the recurrence of stage III colorectal cancer",
abstract = "Background: Extranodal tumor extension (ENTE) is considered a poor prognostic factor in colorectal cancer (CRC). This study aimed to investigate the risk factors for recurrence according to ENTE status in stage III CRC. Methods: We retrospectively evaluated 169 consecutive stage III CRC patients. All patients underwent a curative resection between 2005 and 2010. The presence or absence of ENTE was assessed in the resected lymph nodes. Results: ENTE was observed in 65 (38.5{\%}). Recurrence occurred in 38 patients (22.5{\%}) and was more frequent (p =.041) in the ENTE (+) group. Disease-free survival (p =.016) was significantly shorter in the ENTE (+) group than in the ENTE (−) group. In a univariable analysis, recurrence was associated with vascular invasion (p =.006), perforation (p =.024) in the ENTE (−) group and perforation (p =.048) in the ENTE (+) group. In a Cox’s regression test, vascular invasion (p =.014) and the higher ratio of metastatic lymph nodes/total removed lymph nodes (MLN/TLN) (0.009) in the ENTE (−) group and perforation (p =.025) in the ENTE (+) group were independent risk factors of recurrence. Conclusions: Vascular invasion and the higher ratio of MLN/TLN in ENTE (−) patients and perforation in ENTE (+) patients were independent risk factors of recurrence.",
keywords = "Extranodal tumor extension, colorectal cancer, perforation, recurrence, vascular invasion",
author = "Lee, {Sang Hoon} and Hyunsung Kim and Paik, {Seung Sam} and Lee, {Won Moo} and Lee, {Kang Hong} and Byungkyu Ahn",
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T1 - The usefulness of the status of extranodal tumor extension as a factor that can predict the recurrence of stage III colorectal cancer

AU - Lee, Sang Hoon

AU - Kim, Hyunsung

AU - Paik, Seung Sam

AU - Lee, Won Moo

AU - Lee, Kang Hong

AU - Ahn, Byungkyu

PY - 2019/11/2

Y1 - 2019/11/2

N2 - Background: Extranodal tumor extension (ENTE) is considered a poor prognostic factor in colorectal cancer (CRC). This study aimed to investigate the risk factors for recurrence according to ENTE status in stage III CRC. Methods: We retrospectively evaluated 169 consecutive stage III CRC patients. All patients underwent a curative resection between 2005 and 2010. The presence or absence of ENTE was assessed in the resected lymph nodes. Results: ENTE was observed in 65 (38.5%). Recurrence occurred in 38 patients (22.5%) and was more frequent (p =.041) in the ENTE (+) group. Disease-free survival (p =.016) was significantly shorter in the ENTE (+) group than in the ENTE (−) group. In a univariable analysis, recurrence was associated with vascular invasion (p =.006), perforation (p =.024) in the ENTE (−) group and perforation (p =.048) in the ENTE (+) group. In a Cox’s regression test, vascular invasion (p =.014) and the higher ratio of metastatic lymph nodes/total removed lymph nodes (MLN/TLN) (0.009) in the ENTE (−) group and perforation (p =.025) in the ENTE (+) group were independent risk factors of recurrence. Conclusions: Vascular invasion and the higher ratio of MLN/TLN in ENTE (−) patients and perforation in ENTE (+) patients were independent risk factors of recurrence.

AB - Background: Extranodal tumor extension (ENTE) is considered a poor prognostic factor in colorectal cancer (CRC). This study aimed to investigate the risk factors for recurrence according to ENTE status in stage III CRC. Methods: We retrospectively evaluated 169 consecutive stage III CRC patients. All patients underwent a curative resection between 2005 and 2010. The presence or absence of ENTE was assessed in the resected lymph nodes. Results: ENTE was observed in 65 (38.5%). Recurrence occurred in 38 patients (22.5%) and was more frequent (p =.041) in the ENTE (+) group. Disease-free survival (p =.016) was significantly shorter in the ENTE (+) group than in the ENTE (−) group. In a univariable analysis, recurrence was associated with vascular invasion (p =.006), perforation (p =.024) in the ENTE (−) group and perforation (p =.048) in the ENTE (+) group. In a Cox’s regression test, vascular invasion (p =.014) and the higher ratio of metastatic lymph nodes/total removed lymph nodes (MLN/TLN) (0.009) in the ENTE (−) group and perforation (p =.025) in the ENTE (+) group were independent risk factors of recurrence. Conclusions: Vascular invasion and the higher ratio of MLN/TLN in ENTE (−) patients and perforation in ENTE (+) patients were independent risk factors of recurrence.

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