The role of TURP in the detection of prostate cancer in BPH patients with previously negative prostate biopsy

Dae Keun Kim, Sang Jin Kim, Hong Sang Moon, Sung Yul Park, Yong Tae Kim, Hong Yong Choi, Tchun Yong Lee, Hae Young Park

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Purpose: We aimed to investigate the significance of early detection of transition zone prostate cancer by transurethral resection of prostate (TURP) in benign prostatic hyperplasia (BPH) patients with lower urinary tract symptoms (LUTS) in whom prostate cancer was suspected despite a negative transrectal ultrasonography (TRUS) biopsy result. Materials and Methods: From January 2006 to January 2009, a total of 165 patients who underwent TURP were evaluated. The prostate cancer detection rate was compared between patients who underwent TRUS biopsy before TURP (group A) and those who did not (group B). All charts were evaluated retrospectively, including prostate-specific antigen (PSA), digital rectal examination (DRE), TURP results (including resection volume and pathology report), TRUS, and TRUS biopsy results. Group A was subdivided into group A1, who were diagnosed with prostate cancer after TURP, and group A2, who were diagnosed with BPH after TURP. Results: The cancer detection rate showed no significant difference between groups A and B (8.9% vs. 7.5%, p > 0.05). The mean PSA levels in groups A1 and A2 were 15.5±14.0 ng/ml and 9.1±5.1 ng/ml, respectively (p > 0.05). In group A1, 40% had an abnormal DRE, compared with 6.7% in group A2 (p < 0.05). After TURP, the mean percentage of resected prostatic chips of the prostate cancer group and BPH group were 33.9% and 18.6%, respectively (p=0.001). A positive correlation was found between the detection rate of prostate cancer and PSA (p=0.01). Conclusions: BPH patients in whom prostate cancer is suspected and who have lower urinary tract symptoms (LUTS) with a previously negative TRUS biopsy result can undergo TURP, which results in immediate improvement in bladder outlet obstruction and early diagnosis of clinically significant transition zone prostate cancer.

Original languageEnglish
Pages (from-to)313-317
Number of pages5
JournalKorean Journal of Urology
Volume51
Issue number5
DOIs
StatePublished - 2010 May 1

Fingerprint

Transurethral Resection of Prostate
Prostatic Hyperplasia
Prostate
Prostatic Neoplasms
Biopsy
Ultrasonography
Prostate-Specific Antigen
varespladib methyl
Digital Rectal Examination
Lower Urinary Tract Symptoms
Urinary Bladder Neck Obstruction
Early Diagnosis
Pathology

Keywords

  • Needle biopsy
  • Prostatic neoplasms
  • Transurethral resection of prostate

Cite this

@article{ebc70029111041919dc5907c516dd9b2,
title = "The role of TURP in the detection of prostate cancer in BPH patients with previously negative prostate biopsy",
abstract = "Purpose: We aimed to investigate the significance of early detection of transition zone prostate cancer by transurethral resection of prostate (TURP) in benign prostatic hyperplasia (BPH) patients with lower urinary tract symptoms (LUTS) in whom prostate cancer was suspected despite a negative transrectal ultrasonography (TRUS) biopsy result. Materials and Methods: From January 2006 to January 2009, a total of 165 patients who underwent TURP were evaluated. The prostate cancer detection rate was compared between patients who underwent TRUS biopsy before TURP (group A) and those who did not (group B). All charts were evaluated retrospectively, including prostate-specific antigen (PSA), digital rectal examination (DRE), TURP results (including resection volume and pathology report), TRUS, and TRUS biopsy results. Group A was subdivided into group A1, who were diagnosed with prostate cancer after TURP, and group A2, who were diagnosed with BPH after TURP. Results: The cancer detection rate showed no significant difference between groups A and B (8.9{\%} vs. 7.5{\%}, p > 0.05). The mean PSA levels in groups A1 and A2 were 15.5±14.0 ng/ml and 9.1±5.1 ng/ml, respectively (p > 0.05). In group A1, 40{\%} had an abnormal DRE, compared with 6.7{\%} in group A2 (p < 0.05). After TURP, the mean percentage of resected prostatic chips of the prostate cancer group and BPH group were 33.9{\%} and 18.6{\%}, respectively (p=0.001). A positive correlation was found between the detection rate of prostate cancer and PSA (p=0.01). Conclusions: BPH patients in whom prostate cancer is suspected and who have lower urinary tract symptoms (LUTS) with a previously negative TRUS biopsy result can undergo TURP, which results in immediate improvement in bladder outlet obstruction and early diagnosis of clinically significant transition zone prostate cancer.",
keywords = "Needle biopsy, Prostatic neoplasms, Transurethral resection of prostate",
author = "Kim, {Dae Keun} and Kim, {Sang Jin} and Moon, {Hong Sang} and Park, {Sung Yul} and Kim, {Yong Tae} and Choi, {Hong Yong} and Lee, {Tchun Yong} and Park, {Hae Young}",
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The role of TURP in the detection of prostate cancer in BPH patients with previously negative prostate biopsy. / Kim, Dae Keun; Kim, Sang Jin; Moon, Hong Sang; Park, Sung Yul; Kim, Yong Tae; Choi, Hong Yong; Lee, Tchun Yong; Park, Hae Young.

In: Korean Journal of Urology, Vol. 51, No. 5, 01.05.2010, p. 313-317.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The role of TURP in the detection of prostate cancer in BPH patients with previously negative prostate biopsy

AU - Kim, Dae Keun

AU - Kim, Sang Jin

AU - Moon, Hong Sang

AU - Park, Sung Yul

AU - Kim, Yong Tae

AU - Choi, Hong Yong

AU - Lee, Tchun Yong

AU - Park, Hae Young

PY - 2010/5/1

Y1 - 2010/5/1

N2 - Purpose: We aimed to investigate the significance of early detection of transition zone prostate cancer by transurethral resection of prostate (TURP) in benign prostatic hyperplasia (BPH) patients with lower urinary tract symptoms (LUTS) in whom prostate cancer was suspected despite a negative transrectal ultrasonography (TRUS) biopsy result. Materials and Methods: From January 2006 to January 2009, a total of 165 patients who underwent TURP were evaluated. The prostate cancer detection rate was compared between patients who underwent TRUS biopsy before TURP (group A) and those who did not (group B). All charts were evaluated retrospectively, including prostate-specific antigen (PSA), digital rectal examination (DRE), TURP results (including resection volume and pathology report), TRUS, and TRUS biopsy results. Group A was subdivided into group A1, who were diagnosed with prostate cancer after TURP, and group A2, who were diagnosed with BPH after TURP. Results: The cancer detection rate showed no significant difference between groups A and B (8.9% vs. 7.5%, p > 0.05). The mean PSA levels in groups A1 and A2 were 15.5±14.0 ng/ml and 9.1±5.1 ng/ml, respectively (p > 0.05). In group A1, 40% had an abnormal DRE, compared with 6.7% in group A2 (p < 0.05). After TURP, the mean percentage of resected prostatic chips of the prostate cancer group and BPH group were 33.9% and 18.6%, respectively (p=0.001). A positive correlation was found between the detection rate of prostate cancer and PSA (p=0.01). Conclusions: BPH patients in whom prostate cancer is suspected and who have lower urinary tract symptoms (LUTS) with a previously negative TRUS biopsy result can undergo TURP, which results in immediate improvement in bladder outlet obstruction and early diagnosis of clinically significant transition zone prostate cancer.

AB - Purpose: We aimed to investigate the significance of early detection of transition zone prostate cancer by transurethral resection of prostate (TURP) in benign prostatic hyperplasia (BPH) patients with lower urinary tract symptoms (LUTS) in whom prostate cancer was suspected despite a negative transrectal ultrasonography (TRUS) biopsy result. Materials and Methods: From January 2006 to January 2009, a total of 165 patients who underwent TURP were evaluated. The prostate cancer detection rate was compared between patients who underwent TRUS biopsy before TURP (group A) and those who did not (group B). All charts were evaluated retrospectively, including prostate-specific antigen (PSA), digital rectal examination (DRE), TURP results (including resection volume and pathology report), TRUS, and TRUS biopsy results. Group A was subdivided into group A1, who were diagnosed with prostate cancer after TURP, and group A2, who were diagnosed with BPH after TURP. Results: The cancer detection rate showed no significant difference between groups A and B (8.9% vs. 7.5%, p > 0.05). The mean PSA levels in groups A1 and A2 were 15.5±14.0 ng/ml and 9.1±5.1 ng/ml, respectively (p > 0.05). In group A1, 40% had an abnormal DRE, compared with 6.7% in group A2 (p < 0.05). After TURP, the mean percentage of resected prostatic chips of the prostate cancer group and BPH group were 33.9% and 18.6%, respectively (p=0.001). A positive correlation was found between the detection rate of prostate cancer and PSA (p=0.01). Conclusions: BPH patients in whom prostate cancer is suspected and who have lower urinary tract symptoms (LUTS) with a previously negative TRUS biopsy result can undergo TURP, which results in immediate improvement in bladder outlet obstruction and early diagnosis of clinically significant transition zone prostate cancer.

KW - Needle biopsy

KW - Prostatic neoplasms

KW - Transurethral resection of prostate

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