The role of endogenous histamine on the pathogenesis of the lipopolysaccharide (LPS)-induced, acute lung injury: A pilot study

Tae Hyung Kim, Ho Joo Yoon, Chae Man Lim, Eun Kyung Kim, Mi Jung Kim, Younsuck Koh

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Histamine is widely distributed in the lungs and increases capillary permeability and P-selectin expression. To observe the role of histamine in acute lung injury (ALI), we measured the histamine and protein concentrations and cell numbers in the bronchoalveolar lavage (BAL) of LPS-induced ALI in rats. We instilled LPS (3 mg/kg) intratracheally, in conjunction with the intravenous histamine receptor antagonists (mepyramine, a H1-receptor antagonist, or ranitidine, a H2-receptor antagonist). LPS increased protein concentration and neutrophil numbers in the BAL as well as myeloperoxidase (MPO) activity in lungs after 6 h. LPS also increased histamine concentration in BAL after 2 h. Mepyramine and ranitidine attenuated the increased histamine concentrations. Total cell number in the BAL and MPO activity in the lungs were significantly decreased and neutrophil numbers and protein concentration in the BAL seemed to decrease with the administration of ranitidine at 6 h. In conclusion, endogenous histamine might be involved in the recruitment of neutrophils and protein leaks in LPS-induced ALI via the H2 receptors.

Original languageEnglish
Pages (from-to)8-16
Number of pages9
JournalInflammation
Volume29
Issue number2-3
DOIs
StatePublished - 2005 Apr

Keywords

  • Acute lung injury (ALI)
  • Histamine
  • Histamine receptor antagonists
  • Lipopolysaccharide (LPS)

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