The prognostic significance of pathologic stage T0 on organ-confined bladder transitional cell carcinoma following radical cystectomy

Kang Su Cho, Joo Wan Seo, Sung Yul Park, Nam Hoon Cho, Young Deuk Choi, Seung Choul Yang, Sung Joon Hong

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Introduction: We evaluated the prognostic significance of pT0 stage on organ-confined transitional cell carcinoma of the bladder following radical cystectomy. Patients and Methods: We retrospectively reviewed the medical records of consecutive patients who underwent radical cystectomy for organ-confined transitional cell carcinoma of the bladder between 1986 and 2004. Patients who were treated with neoadjuvant or adjuvant therapy were excluded. A total of 197 patients were enrolled in this study. We investigated the impact of pathologic T stage on disease-specific survival. Results: Overall disease-specific survival rate was 84.1% after 5 years. Five-year disease-specific survival rates according to pathologic stage were 88.7% in pT0, 92.2% in pTis-1 and 65.4% in pT2 disease. Overall disease-specific survival rate with pTis-1 or pT0 tumors was significantly higher than with pT2 tumors (p = 0.001, pT2 vs. pT0; p < 0.001, pT2 vs. pTis-1), but there was no difference in disease-specific survival between pTis-1 and pT0 tumors (p > 0.05). In the muscle-invasive tumor group, pT0 tumors had a more favorable prognosis than pT2 tumors (p = 0.042), but there was no difference in prognosis between pT0 and pTis-1 tumors. Conclusions: Pathologic stage T0 cystectomy can be considered a curative therapy in most cases, including pT0cT2 tumors, but there is a substantial risk of tumor recurrence.

Original languageEnglish
Pages (from-to)394-398
Number of pages5
JournalUrologia Internationalis
Volume81
Issue number4
DOIs
StatePublished - 2008 Dec 1

Keywords

  • Bladder cancer
  • Prognosis
  • Radical cystectomy
  • Staging
  • Transitional cell carcinoma

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