The 'mouse face' appearance of the vertebrae in Paget's disease

Chun Ki Kim, Wilhelmina N. Estrada, Mordechai Lorberboym, Neeta Pandit, Deo G. Religioso, Abass Alavi

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Paget's disease is occasionally found as an incidental finding on bone scans performed for the evaluation of metastatic disease, which causes a diagnostic and a subsequent therapeutic dilemma. We have previously described the 'mouse Face' appearance of vertebrae on bone scans (increased uptake in the vertebral body, posterior elements, and the spinous process), which was fairly specific for Paget's disease in a small series. This retrospective study was undertaken to determine if this observation holds true in a larger series. Bone scans performed in 2,881 patients were randomly selected, and were reviewed by 2 physicians. Thirty-nine cases with a 'mouse Face' appearance were identified. Diagnosis was established in 30 of the 39 patients by correlative radiographic studies and/or clinical follow-up. Twenty patients were referred for the evaluation of possible metastases, and 7 were found to have metastases at the sites of 'mouse Face.' The other 13 had Paget's disease. However, 6 of the 7 patients with metastases had extravertebral findings compatible with multiple metastases, and the remaining patient had a 'mouse Face' lesion only, with a question of metastases. Ten patients were evaluated for Paget's disease or others, and none of them had metastases at the site of the 'mouse Face.' The 'mouse Face' appearance is more suggestive of Paget's disease than metastases even in patients with cancer. These patients should be assumed unlikely to have vertebral metestases, unless proven by another correlative radiologic study.

Original languageEnglish
Pages (from-to)104-108
Number of pages5
JournalClinical nuclear medicine
Volume22
Issue number2
DOIs
StatePublished - 1997 Feb 20

Fingerprint

Spine
Neoplasm Metastasis
Bone and Bones
Incidental Findings
Retrospective Studies
Physicians
Neoplasms

Cite this

Kim, C. K., Estrada, W. N., Lorberboym, M., Pandit, N., Religioso, D. G., & Alavi, A. (1997). The 'mouse face' appearance of the vertebrae in Paget's disease. Clinical nuclear medicine, 22(2), 104-108. https://doi.org/10.1097/00003072-199702000-00007
Kim, Chun Ki ; Estrada, Wilhelmina N. ; Lorberboym, Mordechai ; Pandit, Neeta ; Religioso, Deo G. ; Alavi, Abass. / The 'mouse face' appearance of the vertebrae in Paget's disease. In: Clinical nuclear medicine. 1997 ; Vol. 22, No. 2. pp. 104-108.
@article{0bab00d794d946c7a5a16cbcec4e73ef,
title = "The 'mouse face' appearance of the vertebrae in Paget's disease",
abstract = "Paget's disease is occasionally found as an incidental finding on bone scans performed for the evaluation of metastatic disease, which causes a diagnostic and a subsequent therapeutic dilemma. We have previously described the 'mouse Face' appearance of vertebrae on bone scans (increased uptake in the vertebral body, posterior elements, and the spinous process), which was fairly specific for Paget's disease in a small series. This retrospective study was undertaken to determine if this observation holds true in a larger series. Bone scans performed in 2,881 patients were randomly selected, and were reviewed by 2 physicians. Thirty-nine cases with a 'mouse Face' appearance were identified. Diagnosis was established in 30 of the 39 patients by correlative radiographic studies and/or clinical follow-up. Twenty patients were referred for the evaluation of possible metastases, and 7 were found to have metastases at the sites of 'mouse Face.' The other 13 had Paget's disease. However, 6 of the 7 patients with metastases had extravertebral findings compatible with multiple metastases, and the remaining patient had a 'mouse Face' lesion only, with a question of metastases. Ten patients were evaluated for Paget's disease or others, and none of them had metastases at the site of the 'mouse Face.' The 'mouse Face' appearance is more suggestive of Paget's disease than metastases even in patients with cancer. These patients should be assumed unlikely to have vertebral metestases, unless proven by another correlative radiologic study.",
author = "Kim, {Chun Ki} and Estrada, {Wilhelmina N.} and Mordechai Lorberboym and Neeta Pandit and Religioso, {Deo G.} and Abass Alavi",
year = "1997",
month = "2",
day = "20",
doi = "10.1097/00003072-199702000-00007",
language = "English",
volume = "22",
pages = "104--108",
journal = "Clinical nuclear medicine",
issn = "0363-9762",
number = "2",

}

Kim, CK, Estrada, WN, Lorberboym, M, Pandit, N, Religioso, DG & Alavi, A 1997, 'The 'mouse face' appearance of the vertebrae in Paget's disease', Clinical nuclear medicine, vol. 22, no. 2, pp. 104-108. https://doi.org/10.1097/00003072-199702000-00007

The 'mouse face' appearance of the vertebrae in Paget's disease. / Kim, Chun Ki; Estrada, Wilhelmina N.; Lorberboym, Mordechai; Pandit, Neeta; Religioso, Deo G.; Alavi, Abass.

In: Clinical nuclear medicine, Vol. 22, No. 2, 20.02.1997, p. 104-108.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The 'mouse face' appearance of the vertebrae in Paget's disease

AU - Kim, Chun Ki

AU - Estrada, Wilhelmina N.

AU - Lorberboym, Mordechai

AU - Pandit, Neeta

AU - Religioso, Deo G.

AU - Alavi, Abass

PY - 1997/2/20

Y1 - 1997/2/20

N2 - Paget's disease is occasionally found as an incidental finding on bone scans performed for the evaluation of metastatic disease, which causes a diagnostic and a subsequent therapeutic dilemma. We have previously described the 'mouse Face' appearance of vertebrae on bone scans (increased uptake in the vertebral body, posterior elements, and the spinous process), which was fairly specific for Paget's disease in a small series. This retrospective study was undertaken to determine if this observation holds true in a larger series. Bone scans performed in 2,881 patients were randomly selected, and were reviewed by 2 physicians. Thirty-nine cases with a 'mouse Face' appearance were identified. Diagnosis was established in 30 of the 39 patients by correlative radiographic studies and/or clinical follow-up. Twenty patients were referred for the evaluation of possible metastases, and 7 were found to have metastases at the sites of 'mouse Face.' The other 13 had Paget's disease. However, 6 of the 7 patients with metastases had extravertebral findings compatible with multiple metastases, and the remaining patient had a 'mouse Face' lesion only, with a question of metastases. Ten patients were evaluated for Paget's disease or others, and none of them had metastases at the site of the 'mouse Face.' The 'mouse Face' appearance is more suggestive of Paget's disease than metastases even in patients with cancer. These patients should be assumed unlikely to have vertebral metestases, unless proven by another correlative radiologic study.

AB - Paget's disease is occasionally found as an incidental finding on bone scans performed for the evaluation of metastatic disease, which causes a diagnostic and a subsequent therapeutic dilemma. We have previously described the 'mouse Face' appearance of vertebrae on bone scans (increased uptake in the vertebral body, posterior elements, and the spinous process), which was fairly specific for Paget's disease in a small series. This retrospective study was undertaken to determine if this observation holds true in a larger series. Bone scans performed in 2,881 patients were randomly selected, and were reviewed by 2 physicians. Thirty-nine cases with a 'mouse Face' appearance were identified. Diagnosis was established in 30 of the 39 patients by correlative radiographic studies and/or clinical follow-up. Twenty patients were referred for the evaluation of possible metastases, and 7 were found to have metastases at the sites of 'mouse Face.' The other 13 had Paget's disease. However, 6 of the 7 patients with metastases had extravertebral findings compatible with multiple metastases, and the remaining patient had a 'mouse Face' lesion only, with a question of metastases. Ten patients were evaluated for Paget's disease or others, and none of them had metastases at the site of the 'mouse Face.' The 'mouse Face' appearance is more suggestive of Paget's disease than metastases even in patients with cancer. These patients should be assumed unlikely to have vertebral metestases, unless proven by another correlative radiologic study.

UR - http://www.scopus.com/inward/record.url?scp=0031016426&partnerID=8YFLogxK

U2 - 10.1097/00003072-199702000-00007

DO - 10.1097/00003072-199702000-00007

M3 - Article

C2 - 9031768

AN - SCOPUS:0031016426

VL - 22

SP - 104

EP - 108

JO - Clinical nuclear medicine

JF - Clinical nuclear medicine

SN - 0363-9762

IS - 2

ER -