The effects of variations in genomic modules on breast cancer phenotype

Jinil Han, Hye Young Kim, Min Jung Kim, Jin Hyuk Kim

Research output: Contribution to journalArticle

Abstract

The primary aim of this study is to present how expression heterogeneity is reflected in biological processes. We hypothesize that loss of normal regulatory mechanism is related with changed characteristics of a genomic module, which emerges its own phenotypes as a whole. In breast cancer, receptor status is related to degree of cancer variations. In this regard, comparing expression data according to receptor status is a valuable process to prove the hypothesis. For this reason, we investigated differences of genomic modules according to the receptor status. As a result, 4 and 3 genomic modules, which represent distinct biological processes, were obtained from estrogen receptor (ER)-/ progesterone receptor (PR)-positive double positive (DP) and ER-/PR-negative double negative (DN) breast cancer groups, respectively. Comparing the genomic modules between the groups, we found that there were differences of functional roles, which were mainly caused by DP-exclusive genes. The DP-exclusive genes showed variable expressions in the DN group but not in the DP group, and these expression heterogeneities in the DN group reflected transition of the genomic modules to have more malignant properties than in the DP group. In addition, the DP-exclusive genes themselves have a higher possibility to be involved in oncogenic processes in the DN group. In conclusion, this study suggests that expression heterogeneity of the DP-exclusive genes is not a result of deregulation, but a process that drives emergence of novel traits.

Original languageEnglish
Pages (from-to)296-303
Number of pages8
JournalAnimal Cells and Systems
Volume18
Issue number5
DOIs
StatePublished - 2014 Sep 30

Fingerprint

breast neoplasms
Genes
Breast Neoplasms
Phenotype
Biological Phenomena
genomics
phenotype
Progesterone Receptors
Estrogen Receptors
receptors
genes
Deregulation
neoplasms
Neoplasms
estrogen receptors
progesterone receptors

Keywords

  • breast cancer
  • cancer evolution
  • expression heterogeneity
  • genomic module

Cite this

Han, Jinil ; Kim, Hye Young ; Kim, Min Jung ; Kim, Jin Hyuk. / The effects of variations in genomic modules on breast cancer phenotype. In: Animal Cells and Systems. 2014 ; Vol. 18, No. 5. pp. 296-303.
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The effects of variations in genomic modules on breast cancer phenotype. / Han, Jinil; Kim, Hye Young; Kim, Min Jung; Kim, Jin Hyuk.

In: Animal Cells and Systems, Vol. 18, No. 5, 30.09.2014, p. 296-303.

Research output: Contribution to journalArticle

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