Synthesis of phthalazine derivative based organic nanoflakes in aqueous solvent as a potential nano-anticancer agent: A new approach in medical field

Saubai B. Wakshe, Shilpa R. Patil, Audumbar D. Patil, Prafulla B. Choudhari, Sandeep B. Patil, Prashant V. Anbhule, Daewon Sohn, Govind B. Kolekar

Research output: Contribution to journalArticle

Abstract

A simple phthalazine derivative 13-(4-bromophenyl)-3,3-dimethyl-3,4-dihydro-1H-indazolo[1,2-b] phthalazine-1,6,11(2H,13H)-trione (IDP) was synthesized by Knoevenagel condensation with Michael addition reaction. The present articles deals with preparation of highly fluorescent nanoparticles as prepared drug (IDP) by simple reprecipitation method using single aqueous solvent. The DLS measurement predicted the 150 nm size of a synthesized IDP NPs. Furthermore UV–Visible and fluorescence spectroscopy measurement showed a distinct peak for IDP NPs from their parent molecule. Scanning Electron Microscopy (SEM) microphotograph of air dried film of nanoparticles exhibited nanoflakes type and feathery morphology. The highly fluorescent nature of IDP NPs ultimately revealed in high quantum yield than IDP parent molecule. These fluorescent organic nanoflakes then further applied as anticancer agent. Interestingly it showed better activity than IDP molecules. Thus this is the first report to use organic nanoflakes as an anticancer agent, which may open new avenues in medical field's and related sciences.

Original languageEnglish
Article number127156
JournalJournal of Molecular Structure
Volume1201
DOIs
StatePublished - 2020 Feb 5

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Inosine Diphosphate
Antineoplastic Agents
Derivatives
Molecules
Nanoparticles
Addition reactions
Fluorescence spectroscopy
Quantum yield
phthalazine
Condensation
Scanning electron microscopy

Keywords

  • Anticancer activity
  • Fluorescent organic nanoparticle
  • IDP synthesis
  • Molecular docking
  • Photophysical properties

Cite this

Wakshe, Saubai B. ; Patil, Shilpa R. ; Patil, Audumbar D. ; Choudhari, Prafulla B. ; Patil, Sandeep B. ; Anbhule, Prashant V. ; Sohn, Daewon ; Kolekar, Govind B. / Synthesis of phthalazine derivative based organic nanoflakes in aqueous solvent as a potential nano-anticancer agent : A new approach in medical field. In: Journal of Molecular Structure. 2020 ; Vol. 1201.
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Synthesis of phthalazine derivative based organic nanoflakes in aqueous solvent as a potential nano-anticancer agent : A new approach in medical field. / Wakshe, Saubai B.; Patil, Shilpa R.; Patil, Audumbar D.; Choudhari, Prafulla B.; Patil, Sandeep B.; Anbhule, Prashant V.; Sohn, Daewon; Kolekar, Govind B.

In: Journal of Molecular Structure, Vol. 1201, 127156, 05.02.2020.

Research output: Contribution to journalArticle

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T1 - Synthesis of phthalazine derivative based organic nanoflakes in aqueous solvent as a potential nano-anticancer agent

T2 - A new approach in medical field

AU - Wakshe, Saubai B.

AU - Patil, Shilpa R.

AU - Patil, Audumbar D.

AU - Choudhari, Prafulla B.

AU - Patil, Sandeep B.

AU - Anbhule, Prashant V.

AU - Sohn, Daewon

AU - Kolekar, Govind B.

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AB - A simple phthalazine derivative 13-(4-bromophenyl)-3,3-dimethyl-3,4-dihydro-1H-indazolo[1,2-b] phthalazine-1,6,11(2H,13H)-trione (IDP) was synthesized by Knoevenagel condensation with Michael addition reaction. The present articles deals with preparation of highly fluorescent nanoparticles as prepared drug (IDP) by simple reprecipitation method using single aqueous solvent. The DLS measurement predicted the 150 nm size of a synthesized IDP NPs. Furthermore UV–Visible and fluorescence spectroscopy measurement showed a distinct peak for IDP NPs from their parent molecule. Scanning Electron Microscopy (SEM) microphotograph of air dried film of nanoparticles exhibited nanoflakes type and feathery morphology. The highly fluorescent nature of IDP NPs ultimately revealed in high quantum yield than IDP parent molecule. These fluorescent organic nanoflakes then further applied as anticancer agent. Interestingly it showed better activity than IDP molecules. Thus this is the first report to use organic nanoflakes as an anticancer agent, which may open new avenues in medical field's and related sciences.

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