Abstract
A simple phthalazine derivative 13-(4-bromophenyl)-3,3-dimethyl-3,4-dihydro-1H-indazolo[1,2-b] phthalazine-1,6,11(2H,13H)-trione (IDP) was synthesized by Knoevenagel condensation with Michael addition reaction. The present articles deals with preparation of highly fluorescent nanoparticles as prepared drug (IDP) by simple reprecipitation method using single aqueous solvent. The DLS measurement predicted the 150 nm size of a synthesized IDP NPs. Furthermore UV–Visible and fluorescence spectroscopy measurement showed a distinct peak for IDP NPs from their parent molecule. Scanning Electron Microscopy (SEM) microphotograph of air dried film of nanoparticles exhibited nanoflakes type and feathery morphology. The highly fluorescent nature of IDP NPs ultimately revealed in high quantum yield than IDP parent molecule. These fluorescent organic nanoflakes then further applied as anticancer agent. Interestingly it showed better activity than IDP molecules. Thus this is the first report to use organic nanoflakes as an anticancer agent, which may open new avenues in medical field's and related sciences.
| Original language | English |
|---|---|
| Article number | 127156 |
| Journal | Journal of Molecular Structure |
| Volume | 1201 |
| DOIs | |
| State | Published - 2020 Feb 5 |
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Keywords
- Anticancer activity
- Fluorescent organic nanoparticle
- IDP synthesis
- Molecular docking
- Photophysical properties
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Synthesis of phthalazine derivative based organic nanoflakes in aqueous solvent as a potential nano-anticancer agent : A new approach in medical field. / Wakshe, Saubai B.; Patil, Shilpa R.; Patil, Audumbar D.; Choudhari, Prafulla B.; Patil, Sandeep B.; Anbhule, Prashant V.; Sohn, Daewon; Kolekar, Govind B.
In: Journal of Molecular Structure, Vol. 1201, 127156, 05.02.2020.Research output: Contribution to journal › Article
TY - JOUR
T1 - Synthesis of phthalazine derivative based organic nanoflakes in aqueous solvent as a potential nano-anticancer agent
T2 - A new approach in medical field
AU - Wakshe, Saubai B.
AU - Patil, Shilpa R.
AU - Patil, Audumbar D.
AU - Choudhari, Prafulla B.
AU - Patil, Sandeep B.
AU - Anbhule, Prashant V.
AU - Sohn, Daewon
AU - Kolekar, Govind B.
PY - 2020/2/5
Y1 - 2020/2/5
N2 - A simple phthalazine derivative 13-(4-bromophenyl)-3,3-dimethyl-3,4-dihydro-1H-indazolo[1,2-b] phthalazine-1,6,11(2H,13H)-trione (IDP) was synthesized by Knoevenagel condensation with Michael addition reaction. The present articles deals with preparation of highly fluorescent nanoparticles as prepared drug (IDP) by simple reprecipitation method using single aqueous solvent. The DLS measurement predicted the 150 nm size of a synthesized IDP NPs. Furthermore UV–Visible and fluorescence spectroscopy measurement showed a distinct peak for IDP NPs from their parent molecule. Scanning Electron Microscopy (SEM) microphotograph of air dried film of nanoparticles exhibited nanoflakes type and feathery morphology. The highly fluorescent nature of IDP NPs ultimately revealed in high quantum yield than IDP parent molecule. These fluorescent organic nanoflakes then further applied as anticancer agent. Interestingly it showed better activity than IDP molecules. Thus this is the first report to use organic nanoflakes as an anticancer agent, which may open new avenues in medical field's and related sciences.
AB - A simple phthalazine derivative 13-(4-bromophenyl)-3,3-dimethyl-3,4-dihydro-1H-indazolo[1,2-b] phthalazine-1,6,11(2H,13H)-trione (IDP) was synthesized by Knoevenagel condensation with Michael addition reaction. The present articles deals with preparation of highly fluorescent nanoparticles as prepared drug (IDP) by simple reprecipitation method using single aqueous solvent. The DLS measurement predicted the 150 nm size of a synthesized IDP NPs. Furthermore UV–Visible and fluorescence spectroscopy measurement showed a distinct peak for IDP NPs from their parent molecule. Scanning Electron Microscopy (SEM) microphotograph of air dried film of nanoparticles exhibited nanoflakes type and feathery morphology. The highly fluorescent nature of IDP NPs ultimately revealed in high quantum yield than IDP parent molecule. These fluorescent organic nanoflakes then further applied as anticancer agent. Interestingly it showed better activity than IDP molecules. Thus this is the first report to use organic nanoflakes as an anticancer agent, which may open new avenues in medical field's and related sciences.
KW - Anticancer activity
KW - Fluorescent organic nanoparticle
KW - IDP synthesis
KW - Molecular docking
KW - Photophysical properties
UR - http://www.scopus.com/inward/record.url?scp=85073523196&partnerID=8YFLogxK
U2 - 10.1016/j.molstruc.2019.127156
DO - 10.1016/j.molstruc.2019.127156
M3 - Article
AN - SCOPUS:85073523196
VL - 1201
JO - Journal of Molecular Structure
JF - Journal of Molecular Structure
SN - 0022-2860
M1 - 127156
ER -