Synthesis of novel phytosphingosine derivatives and their preliminary biological evaluation for enhancing radiation therapy

Byung Seok Moon, Moon Taek Park, Jeong Hoon Park, Sang Wook Kim, Kyo Chul Lee, Gwang Il An, Seung Dae Yang, Dae Yoon Chi, Gi Jeong Cheon, Su Jae Lee

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Eight d-ribo-phytosphingosine derivatives were synthesized from d-ribo-phytosphingosine and diverse acyl chlorides with N,N-diisopropylethylamine in tetrahydrofuran for 1 h at room temperature. Effect of these compounds on IR-induced cell death was evaluated on blood cancer cells (Jurkat). Among these, 3d showed the highest enhancement of radiosensitizing effect.

Original languageEnglish
Pages (from-to)6643-6646
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume17
Issue number23
DOIs
StatePublished - 2007 Dec 1

Fingerprint

phytosphingosine
Radiotherapy
Radiation-Sensitizing Agents
Derivatives
Cell death
Chlorides
Blood Cells
Blood
Cell Death
Cells
Temperature
Neoplasms

Keywords

  • Phytoceramide
  • Phytosphingosine
  • Radiosensitizer
  • Sphingolipids

Cite this

Moon, Byung Seok ; Park, Moon Taek ; Park, Jeong Hoon ; Kim, Sang Wook ; Lee, Kyo Chul ; An, Gwang Il ; Yang, Seung Dae ; Chi, Dae Yoon ; Cheon, Gi Jeong ; Lee, Su Jae. / Synthesis of novel phytosphingosine derivatives and their preliminary biological evaluation for enhancing radiation therapy. In: Bioorganic and Medicinal Chemistry Letters. 2007 ; Vol. 17, No. 23. pp. 6643-6646.
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Synthesis of novel phytosphingosine derivatives and their preliminary biological evaluation for enhancing radiation therapy. / Moon, Byung Seok; Park, Moon Taek; Park, Jeong Hoon; Kim, Sang Wook; Lee, Kyo Chul; An, Gwang Il; Yang, Seung Dae; Chi, Dae Yoon; Cheon, Gi Jeong; Lee, Su Jae.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 17, No. 23, 01.12.2007, p. 6643-6646.

Research output: Contribution to journalArticle

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AU - Moon, Byung Seok

AU - Park, Moon Taek

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AU - Kim, Sang Wook

AU - Lee, Kyo Chul

AU - An, Gwang Il

AU - Yang, Seung Dae

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AU - Cheon, Gi Jeong

AU - Lee, Su Jae

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