Abstract
Dendrons and dendrimers with cationic amino groups at their periphery were successfully synthesized up to the third and second generation, respectively. The results obtained by 1H NMR spectroscopy and gel permeation chromatography analysis supported the formation of the targeted dendrons and dendrimers. The dendrons were grown via ester linkages, which endowed them with biodegradability in D2O at 37°C. The degradation rate depends upon the steric hindrance and reactivity caused by the bulkiness and compact structure of the dendrons. All of the synthesized dendrons were degraded within a month, while 60% of the ester groups in the sterically crowded dendrimers were degraded over the same time period. The cytotoxicity of the dendrons was evaluated by the MTT assay on a 293T cell line which indicated that the obtained dendrons were completely non-toxic. These non-toxic, biodegradable cationic dendrons and dendrimers are believed to have potential applications in the biomedical field.
| Original language | English |
|---|---|
| Pages (from-to) | 1608-1614 |
| Number of pages | 7 |
| Journal | Macromolecular Rapid Communications |
| Volume | 27 |
| Issue number | 18 |
| DOIs | |
| State | Published - 2006 Sep 22 |
Fingerprint
Keywords
- Biodegradable
- Dendrimers
- Dendrons
- Non-toxicity
- Polyesters
Cite this
}
Synthesis of novel biodegradable cationic dendrimers. / Lee, Jin Seong; Huh, June; Ahn, Cheol Hee; Lee, Minhyung; Park, Tae Gwan.
In: Macromolecular Rapid Communications, Vol. 27, No. 18, 22.09.2006, p. 1608-1614.Research output: Contribution to journal › Article
TY - JOUR
T1 - Synthesis of novel biodegradable cationic dendrimers
AU - Lee, Jin Seong
AU - Huh, June
AU - Ahn, Cheol Hee
AU - Lee, Minhyung
AU - Park, Tae Gwan
PY - 2006/9/22
Y1 - 2006/9/22
N2 - Dendrons and dendrimers with cationic amino groups at their periphery were successfully synthesized up to the third and second generation, respectively. The results obtained by 1H NMR spectroscopy and gel permeation chromatography analysis supported the formation of the targeted dendrons and dendrimers. The dendrons were grown via ester linkages, which endowed them with biodegradability in D2O at 37°C. The degradation rate depends upon the steric hindrance and reactivity caused by the bulkiness and compact structure of the dendrons. All of the synthesized dendrons were degraded within a month, while 60% of the ester groups in the sterically crowded dendrimers were degraded over the same time period. The cytotoxicity of the dendrons was evaluated by the MTT assay on a 293T cell line which indicated that the obtained dendrons were completely non-toxic. These non-toxic, biodegradable cationic dendrons and dendrimers are believed to have potential applications in the biomedical field.
AB - Dendrons and dendrimers with cationic amino groups at their periphery were successfully synthesized up to the third and second generation, respectively. The results obtained by 1H NMR spectroscopy and gel permeation chromatography analysis supported the formation of the targeted dendrons and dendrimers. The dendrons were grown via ester linkages, which endowed them with biodegradability in D2O at 37°C. The degradation rate depends upon the steric hindrance and reactivity caused by the bulkiness and compact structure of the dendrons. All of the synthesized dendrons were degraded within a month, while 60% of the ester groups in the sterically crowded dendrimers were degraded over the same time period. The cytotoxicity of the dendrons was evaluated by the MTT assay on a 293T cell line which indicated that the obtained dendrons were completely non-toxic. These non-toxic, biodegradable cationic dendrons and dendrimers are believed to have potential applications in the biomedical field.
KW - Biodegradable
KW - Dendrimers
KW - Dendrons
KW - Non-toxicity
KW - Polyesters
UR - http://www.scopus.com/inward/record.url?scp=33749562616&partnerID=8YFLogxK
U2 - 10.1002/marc.200600393
DO - 10.1002/marc.200600393
M3 - Article
AN - SCOPUS:33749562616
VL - 27
SP - 1608
EP - 1614
JO - Macromolecular Rapid Communications
JF - Macromolecular Rapid Communications
SN - 1022-1336
IS - 18
ER -