Abstract
A stable derivative of L-ascorbic acid, 2-O-[(3-aminopropyl)phosphinooxy]-L-ascorbic acid (LAAP), was synthesized in moderate yield and its chemical stability and effects on melanin synthesis were investigated. L-Ascorbic acid was decomposed completely within about 1 hour, while 93% of LAAP remained even after 10 days. Treatment of L-ascorbic acid and LAAP decreased melanin content in normal human melanocytes to 33.8% and 49.1% of control at 2 mM, respectively. Considering chemical instability of L-ascorbic acid, LAAP is a much better whitening agent.
| Original language | English |
|---|---|
| Pages (from-to) | 1169-1171 |
| Number of pages | 3 |
| Journal | Bulletin of the Korean Chemical Society |
| Volume | 24 |
| Issue number | 8 |
| DOIs | |
| State | Published - 2003 Aug 20 |
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Keywords
- 2-O-[(3-Aminopropyl)phosphinooxy]-L-ascorbic acid (LAAP)
- Whitening agent
Cite this
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Synthesis of L-Ascorbic Acid Derivative Including 3-Aminopropane Phosphoric Acid as a Novel Whitening Agent. / Kang, Hak Hee; Oh, Seong-Geun.
In: Bulletin of the Korean Chemical Society, Vol. 24, No. 8, 20.08.2003, p. 1169-1171.Research output: Contribution to journal › Article
TY - JOUR
T1 - Synthesis of L-Ascorbic Acid Derivative Including 3-Aminopropane Phosphoric Acid as a Novel Whitening Agent
AU - Kang, Hak Hee
AU - Oh, Seong-Geun
PY - 2003/8/20
Y1 - 2003/8/20
N2 - A stable derivative of L-ascorbic acid, 2-O-[(3-aminopropyl)phosphinooxy]-L-ascorbic acid (LAAP), was synthesized in moderate yield and its chemical stability and effects on melanin synthesis were investigated. L-Ascorbic acid was decomposed completely within about 1 hour, while 93% of LAAP remained even after 10 days. Treatment of L-ascorbic acid and LAAP decreased melanin content in normal human melanocytes to 33.8% and 49.1% of control at 2 mM, respectively. Considering chemical instability of L-ascorbic acid, LAAP is a much better whitening agent.
AB - A stable derivative of L-ascorbic acid, 2-O-[(3-aminopropyl)phosphinooxy]-L-ascorbic acid (LAAP), was synthesized in moderate yield and its chemical stability and effects on melanin synthesis were investigated. L-Ascorbic acid was decomposed completely within about 1 hour, while 93% of LAAP remained even after 10 days. Treatment of L-ascorbic acid and LAAP decreased melanin content in normal human melanocytes to 33.8% and 49.1% of control at 2 mM, respectively. Considering chemical instability of L-ascorbic acid, LAAP is a much better whitening agent.
KW - 2-O-[(3-Aminopropyl)phosphinooxy]-L-ascorbic acid (LAAP)
KW - Whitening agent
UR - http://www.scopus.com/inward/record.url?scp=0344875701&partnerID=8YFLogxK
U2 - 10.5012/bkcs.2003.24.8.1169
DO - 10.5012/bkcs.2003.24.8.1169
M3 - Article
AN - SCOPUS:0344875701
VL - 24
SP - 1169
EP - 1171
JO - Bulletin of the Korean Chemical Society
JF - Bulletin of the Korean Chemical Society
SN - 0253-2964
IS - 8
ER -