Synthesis and degradation behaviors of PEO/PL/PEO tri-block copolymers

Soo Hong Lee, Soo Hyun Kim, Young Ha Kim, Yang-Kyoo Han

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Poly(ethylene oxide)/polylatide/poly(ethylene oxide) (PEO/PL/PEO) tri-block copolymers, which each block is connected by ester bond, were synthesized by coupling reaction of PL with PEO in the presence of pyridine. PL/PEO/PL tri-block copolymer was synthesized by ring opening polymerization of L-lactide initiated by PEO in the presence of stannous octoate. Degradation behavior of the copolymers was investigated in a pH 7.4 phosphate buffer saline (PBS) at 37±1°C. Gel permeation chromatography (GPC) and 1H-nuclear magnetic resonance (NMR) were used to monitor the change of mass loss, molecular weight and composition of copolymers. In hydrolytic degradation, the PEO/PL/PEO tri-block copolymer with high PEO contents affected the increase of its mass loss, and resulted in the decrease of its molecular weight as well as PEO composition. However, when PL/PEO/PL and PEO/PL/PEO tri-block copolymers had similar PEO contents, PEO/PL/PEO decreased faster in molecular weight and PEO composition than PL/PEO/PL.

Original languageEnglish
Pages (from-to)85-90
Number of pages6
JournalMacromolecular Research
Volume10
Issue number2
DOIs
StatePublished - 2002 Jan 1

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Polyethylene oxides
Block copolymers
Degradation
Molecular weight
Copolymers
Chemical analysis
Ring opening polymerization
Gel permeation chromatography
Pyridine

Keywords

  • Biodegradable polymer
  • Hydrolytic degradation
  • Poly(ethylene oxide)
  • Polylactide
  • Tri-block copolymer

Cite this

Lee, Soo Hong ; Kim, Soo Hyun ; Kim, Young Ha ; Han, Yang-Kyoo. / Synthesis and degradation behaviors of PEO/PL/PEO tri-block copolymers. In: Macromolecular Research. 2002 ; Vol. 10, No. 2. pp. 85-90.
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abstract = "Poly(ethylene oxide)/polylatide/poly(ethylene oxide) (PEO/PL/PEO) tri-block copolymers, which each block is connected by ester bond, were synthesized by coupling reaction of PL with PEO in the presence of pyridine. PL/PEO/PL tri-block copolymer was synthesized by ring opening polymerization of L-lactide initiated by PEO in the presence of stannous octoate. Degradation behavior of the copolymers was investigated in a pH 7.4 phosphate buffer saline (PBS) at 37±1°C. Gel permeation chromatography (GPC) and 1H-nuclear magnetic resonance (NMR) were used to monitor the change of mass loss, molecular weight and composition of copolymers. In hydrolytic degradation, the PEO/PL/PEO tri-block copolymer with high PEO contents affected the increase of its mass loss, and resulted in the decrease of its molecular weight as well as PEO composition. However, when PL/PEO/PL and PEO/PL/PEO tri-block copolymers had similar PEO contents, PEO/PL/PEO decreased faster in molecular weight and PEO composition than PL/PEO/PL.",
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Synthesis and degradation behaviors of PEO/PL/PEO tri-block copolymers. / Lee, Soo Hong; Kim, Soo Hyun; Kim, Young Ha; Han, Yang-Kyoo.

In: Macromolecular Research, Vol. 10, No. 2, 01.01.2002, p. 85-90.

Research output: Contribution to journalArticle

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