Synthesis and biological evaluation of rhodanine derivatives as PRL-3 inhibitors

Jin Hee Ahn, Seung Jun Kim, Woul Seong Park, Sung Yun Cho, Jae Du Ha, Sung Soo Kim, Seung Kyu Kang, Dae Gwin Jeong, Suk Kyeong Jung, Sang Hyeup Lee, Hwan Mook Kim, Song Kyu Park, Ki Ho Lee, Chang Woo Lee, Seong Eon Ryu, Joong Kwon Choi

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Abstract

A series of rhodanine derivatives was synthesized and evaluated for their ability to inhibit PRL-3. Benzylidene rhodanine derivative showed good biological activity, while compound 5e was the most active in this series exhibiting an IC50 value of 0.9 μM in vitro and showed a reduced invasion in cell-based assay.

Original languageEnglish
Pages (from-to)2996-2999
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume16
Issue number11
DOIs
StatePublished - 2006 Jun 1

Keywords

  • Cancer
  • Inhibitor
  • Metastasis
  • PRL-3
  • Rhodanine

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    Ahn, J. H., Kim, S. J., Park, W. S., Cho, S. Y., Ha, J. D., Kim, S. S., Kang, S. K., Jeong, D. G., Jung, S. K., Lee, S. H., Kim, H. M., Park, S. K., Lee, K. H., Lee, C. W., Ryu, S. E., & Choi, J. K. (2006). Synthesis and biological evaluation of rhodanine derivatives as PRL-3 inhibitors. Bioorganic and Medicinal Chemistry Letters, 16(11), 2996-2999. https://doi.org/10.1016/j.bmcl.2006.02.060