Synthesis and antibacterial evaluation of 1β-methyl-2-[5-(1-methoxyimino-2-substituted sulfonamide ethyl)pyrrolidin-3-ylthio]carbapenems and their related compounds

Heechol Jeon, Nam Hyun Jo, Kyung Ho Yoo, Junghoon Choi, Heeyeong Cho, Jung Hyuck Cho, Chang Hyun Oh

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The synthesis of a new series of 1β-methylcarbapenems having methoxyimine and substituted sulfonamide moieties is described. Their in vitro antibacterial activities against both Gram-positive and Gram-negative bacteria were tested and the effect of substituents on the pyrrolidine ring was investigated. A particular compound (IIIc) having methylaminosulfonamide moiety showed the most potent antibacterial activity.

Original languageEnglish
Pages (from-to)358-364
Number of pages7
JournalEuropean Journal of Medicinal Chemistry
Volume42
Issue number3
DOIs
StatePublished - 2007 Mar 1

Fingerprint

Carbapenems
Sulfonamides
Gram-Negative Bacteria
Bacteria
In Vitro Techniques
1 beta-methylcarbapenem
methoxyimine
pyrrolidine

Keywords

  • 1β-Methylcarbapenems
  • Antibacterial activity
  • DHP-I stability

Cite this

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Synthesis and antibacterial evaluation of 1β-methyl-2-[5-(1-methoxyimino-2-substituted sulfonamide ethyl)pyrrolidin-3-ylthio]carbapenems and their related compounds. / Jeon, Heechol; Jo, Nam Hyun; Yoo, Kyung Ho; Choi, Junghoon; Cho, Heeyeong; Cho, Jung Hyuck; Oh, Chang Hyun.

In: European Journal of Medicinal Chemistry, Vol. 42, No. 3, 01.03.2007, p. 358-364.

Research output: Contribution to journalArticle

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T1 - Synthesis and antibacterial evaluation of 1β-methyl-2-[5-(1-methoxyimino-2-substituted sulfonamide ethyl)pyrrolidin-3-ylthio]carbapenems and their related compounds

AU - Jeon, Heechol

AU - Jo, Nam Hyun

AU - Yoo, Kyung Ho

AU - Choi, Junghoon

AU - Cho, Heeyeong

AU - Cho, Jung Hyuck

AU - Oh, Chang Hyun

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KW - 1β-Methylcarbapenems

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KW - DHP-I stability

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