STX0119 ameliorates arthritis in SKG mice via inhibiting T helper 17

Faisal Hayat, Seung Hoon Lee, Eun Jung Lee, Seok Jung Kim, Kyung Ah Jung, Soon Kyu Lee, Jeehee Youn, Jun Ki Min, Mi La Cho, Dong Yun Shin

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5 Scopus citations

Abstract

Rheumatoid arthritis (RA) is an autoimmune disease with chronic and excessive inflammation. Upregulation of interleukin (IL)-17 is involved in the pathogenesis of RA. STX0119 is a specific inhibitor of signal transducer and activator of transcription 3 (STAT3) as a potential target for the treatment of RA. STAT3 is a member of DNA-binding molecules that regulates the expression of proinflammatory cytokines involved in the pathogenesis of RA. The objective of this study was to determine whether STX0119 could inhibit STAT3 and IL-17. We demonstrated that STX0119 decreased T helper (Th) 17 differentiation and IL-17 expression in vitro. STX0119 also improved the severity of zymosan induced arthritis and reduced joint inflammation. STX0119 reduced the proliferation of Th17 and phosphorylated STAT3 expression while increasing Treg differentiation and phosphorylated STAT5 expression. Moreover, STX0119 decreased the expression of IL-6 and -17 but not IL-10. These findings suggest that STX0119 can be used to treat autoimmune RA through inhibiting the activation of STAT3.

Original languageEnglish
Pages (from-to)91-99
Number of pages9
JournalTissue Engineering and Regenerative Medicine
Volume13
Issue number1
DOIs
StatePublished - 2016 Feb 1

Keywords

  • Immune modualtion
  • Rheumatoid arthritis
  • Signal transducer and activator of transcription 3 inhibitor
  • T helper 17
  • Treg

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    Hayat, F., Lee, S. H., Lee, E. J., Kim, S. J., Jung, K. A., Lee, S. K., Youn, J., Min, J. K., Cho, M. L., & Shin, D. Y. (2016). STX0119 ameliorates arthritis in SKG mice via inhibiting T helper 17. Tissue Engineering and Regenerative Medicine, 13(1), 91-99. https://doi.org/10.1007/s13770-016-9086-0