Stable hepatocyte transplantation using fibrin matrix

So Jung Gwak, Dongho Choi, Seung Sam Paik, Eun Yeol Lee, Kwang Soo Lee, Byung Soo Kim

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Fibrin matrix, a naturally derived biodegradable polymer matrix, was evaluated as a scaffold for hepatocyte transplantation in an athymic mouse model. One week after transplantation, opaque conglomerates of the transplanted hepatocytes and fibrin matrix were found on the intestinal mesentery, whereas no transplanted hepatocytes were observed in control groups (transplantation of hepatocytes suspended in culture medium). The hepatocytes in the conglomerates retained hepatocyte-specific functions, as examined with histochemical and immunohistochemical stainings. Stable hepatocyte engraftment may thus be achieved by hepatocyte transplantation using fibrin matrix.

Original languageEnglish
Pages (from-to)505-508
Number of pages4
JournalBiotechnology Letters
Volume26
Issue number6
DOIs
StatePublished - 2004 Mar 1

Fingerprint

Fibrin
Hepatocytes
Transplantation
Biodegradable polymers
Mesentery
Polymer matrix
Nude Mice
Scaffolds
Culture Media
Polymers
Staining and Labeling
Control Groups

Keywords

  • Fibrin matrix
  • Hepatocyte transplantation
  • Injectable polymer

Cite this

Gwak, So Jung ; Choi, Dongho ; Paik, Seung Sam ; Lee, Eun Yeol ; Lee, Kwang Soo ; Kim, Byung Soo. / Stable hepatocyte transplantation using fibrin matrix. In: Biotechnology Letters. 2004 ; Vol. 26, No. 6. pp. 505-508.
@article{9bfb210bd3474187849f285b02af4e06,
title = "Stable hepatocyte transplantation using fibrin matrix",
abstract = "Fibrin matrix, a naturally derived biodegradable polymer matrix, was evaluated as a scaffold for hepatocyte transplantation in an athymic mouse model. One week after transplantation, opaque conglomerates of the transplanted hepatocytes and fibrin matrix were found on the intestinal mesentery, whereas no transplanted hepatocytes were observed in control groups (transplantation of hepatocytes suspended in culture medium). The hepatocytes in the conglomerates retained hepatocyte-specific functions, as examined with histochemical and immunohistochemical stainings. Stable hepatocyte engraftment may thus be achieved by hepatocyte transplantation using fibrin matrix.",
keywords = "Fibrin matrix, Hepatocyte transplantation, Injectable polymer",
author = "Gwak, {So Jung} and Dongho Choi and Paik, {Seung Sam} and Lee, {Eun Yeol} and Lee, {Kwang Soo} and Kim, {Byung Soo}",
year = "2004",
month = "3",
day = "1",
doi = "10.1023/B:BILE.0000019558.99209.84",
language = "English",
volume = "26",
pages = "505--508",
journal = "Biotechnology letters",
issn = "0141-5492",
number = "6",

}

Stable hepatocyte transplantation using fibrin matrix. / Gwak, So Jung; Choi, Dongho; Paik, Seung Sam; Lee, Eun Yeol; Lee, Kwang Soo; Kim, Byung Soo.

In: Biotechnology Letters, Vol. 26, No. 6, 01.03.2004, p. 505-508.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Stable hepatocyte transplantation using fibrin matrix

AU - Gwak, So Jung

AU - Choi, Dongho

AU - Paik, Seung Sam

AU - Lee, Eun Yeol

AU - Lee, Kwang Soo

AU - Kim, Byung Soo

PY - 2004/3/1

Y1 - 2004/3/1

N2 - Fibrin matrix, a naturally derived biodegradable polymer matrix, was evaluated as a scaffold for hepatocyte transplantation in an athymic mouse model. One week after transplantation, opaque conglomerates of the transplanted hepatocytes and fibrin matrix were found on the intestinal mesentery, whereas no transplanted hepatocytes were observed in control groups (transplantation of hepatocytes suspended in culture medium). The hepatocytes in the conglomerates retained hepatocyte-specific functions, as examined with histochemical and immunohistochemical stainings. Stable hepatocyte engraftment may thus be achieved by hepatocyte transplantation using fibrin matrix.

AB - Fibrin matrix, a naturally derived biodegradable polymer matrix, was evaluated as a scaffold for hepatocyte transplantation in an athymic mouse model. One week after transplantation, opaque conglomerates of the transplanted hepatocytes and fibrin matrix were found on the intestinal mesentery, whereas no transplanted hepatocytes were observed in control groups (transplantation of hepatocytes suspended in culture medium). The hepatocytes in the conglomerates retained hepatocyte-specific functions, as examined with histochemical and immunohistochemical stainings. Stable hepatocyte engraftment may thus be achieved by hepatocyte transplantation using fibrin matrix.

KW - Fibrin matrix

KW - Hepatocyte transplantation

KW - Injectable polymer

UR - http://www.scopus.com/inward/record.url?scp=1842430836&partnerID=8YFLogxK

U2 - 10.1023/B:BILE.0000019558.99209.84

DO - 10.1023/B:BILE.0000019558.99209.84

M3 - Article

C2 - 15127792

AN - SCOPUS:1842430836

VL - 26

SP - 505

EP - 508

JO - Biotechnology letters

JF - Biotechnology letters

SN - 0141-5492

IS - 6

ER -