Simple detection of binding events using an anchoring transition of liquid crystals on the immobilized oligoDNAs

Hak Rin Kim, Min Geon Choi, Joo Eun Kim, Eui Yul Choi, Sang Wook Oh, Jae Hoon Kim

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We propose a novel method for optically detecting hybridization results in a deoxyribonucleic acid (DNA) chip using an anchoring transition of a nematic liquid crystal (NLC). Since the LC anchoring condition highly depends on variation of the surface morphology, DNA hybridization result induces an anchoring transition of NLCs from a homeotropic orientation to a random planar orientation. It is demonstrated that such hybridization results and the subsequent anchoring transition of LCs are detectable with simple optical instruments by utilizing large optical birefringence variation and propagation of the long-range orientational order in NLCs.

Original languageEnglish
Title of host publicationNanostructured Materials and Hybrid Composites for Gas Sensors and Biomedical Applications
Pages47-51
Number of pages5
StatePublished - 2006 Oct 9
Event2006 Materials Research Society Spring Meeting - San Francisco, CA, United States
Duration: 2006 Apr 182006 Apr 20

Publication series

NameMaterials Research Society Symposium Proceedings
Volume915
ISSN (Print)0272-9172

Other

Other2006 Materials Research Society Spring Meeting
CountryUnited States
CitySan Francisco, CA
Period06/04/1806/04/20

Fingerprint

Liquid Crystals
Liquid crystals
DNA
liquid crystals
Optical instruments
Nematic liquid crystals
deoxyribonucleic acid
Birefringence
Surface morphology
birefringence
chips
propagation

Cite this

Kim, H. R., Choi, M. G., Kim, J. E., Choi, E. Y., Oh, S. W., & Kim, J. H. (2006). Simple detection of binding events using an anchoring transition of liquid crystals on the immobilized oligoDNAs. In Nanostructured Materials and Hybrid Composites for Gas Sensors and Biomedical Applications (pp. 47-51). (Materials Research Society Symposium Proceedings; Vol. 915).
Kim, Hak Rin ; Choi, Min Geon ; Kim, Joo Eun ; Choi, Eui Yul ; Oh, Sang Wook ; Kim, Jae Hoon. / Simple detection of binding events using an anchoring transition of liquid crystals on the immobilized oligoDNAs. Nanostructured Materials and Hybrid Composites for Gas Sensors and Biomedical Applications. 2006. pp. 47-51 (Materials Research Society Symposium Proceedings).
@inproceedings{aff9de51b6dc437e87135e5f70700add,
title = "Simple detection of binding events using an anchoring transition of liquid crystals on the immobilized oligoDNAs",
abstract = "We propose a novel method for optically detecting hybridization results in a deoxyribonucleic acid (DNA) chip using an anchoring transition of a nematic liquid crystal (NLC). Since the LC anchoring condition highly depends on variation of the surface morphology, DNA hybridization result induces an anchoring transition of NLCs from a homeotropic orientation to a random planar orientation. It is demonstrated that such hybridization results and the subsequent anchoring transition of LCs are detectable with simple optical instruments by utilizing large optical birefringence variation and propagation of the long-range orientational order in NLCs.",
author = "Kim, {Hak Rin} and Choi, {Min Geon} and Kim, {Joo Eun} and Choi, {Eui Yul} and Oh, {Sang Wook} and Kim, {Jae Hoon}",
year = "2006",
month = "10",
day = "9",
language = "English",
isbn = "9781558998711",
series = "Materials Research Society Symposium Proceedings",
pages = "47--51",
booktitle = "Nanostructured Materials and Hybrid Composites for Gas Sensors and Biomedical Applications",

}

Kim, HR, Choi, MG, Kim, JE, Choi, EY, Oh, SW & Kim, JH 2006, Simple detection of binding events using an anchoring transition of liquid crystals on the immobilized oligoDNAs. in Nanostructured Materials and Hybrid Composites for Gas Sensors and Biomedical Applications. Materials Research Society Symposium Proceedings, vol. 915, pp. 47-51, 2006 Materials Research Society Spring Meeting, San Francisco, CA, United States, 06/04/18.

Simple detection of binding events using an anchoring transition of liquid crystals on the immobilized oligoDNAs. / Kim, Hak Rin; Choi, Min Geon; Kim, Joo Eun; Choi, Eui Yul; Oh, Sang Wook; Kim, Jae Hoon.

Nanostructured Materials and Hybrid Composites for Gas Sensors and Biomedical Applications. 2006. p. 47-51 (Materials Research Society Symposium Proceedings; Vol. 915).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

TY - GEN

T1 - Simple detection of binding events using an anchoring transition of liquid crystals on the immobilized oligoDNAs

AU - Kim, Hak Rin

AU - Choi, Min Geon

AU - Kim, Joo Eun

AU - Choi, Eui Yul

AU - Oh, Sang Wook

AU - Kim, Jae Hoon

PY - 2006/10/9

Y1 - 2006/10/9

N2 - We propose a novel method for optically detecting hybridization results in a deoxyribonucleic acid (DNA) chip using an anchoring transition of a nematic liquid crystal (NLC). Since the LC anchoring condition highly depends on variation of the surface morphology, DNA hybridization result induces an anchoring transition of NLCs from a homeotropic orientation to a random planar orientation. It is demonstrated that such hybridization results and the subsequent anchoring transition of LCs are detectable with simple optical instruments by utilizing large optical birefringence variation and propagation of the long-range orientational order in NLCs.

AB - We propose a novel method for optically detecting hybridization results in a deoxyribonucleic acid (DNA) chip using an anchoring transition of a nematic liquid crystal (NLC). Since the LC anchoring condition highly depends on variation of the surface morphology, DNA hybridization result induces an anchoring transition of NLCs from a homeotropic orientation to a random planar orientation. It is demonstrated that such hybridization results and the subsequent anchoring transition of LCs are detectable with simple optical instruments by utilizing large optical birefringence variation and propagation of the long-range orientational order in NLCs.

UR - http://www.scopus.com/inward/record.url?scp=33749336408&partnerID=8YFLogxK

M3 - Conference contribution

AN - SCOPUS:33749336408

SN - 9781558998711

T3 - Materials Research Society Symposium Proceedings

SP - 47

EP - 51

BT - Nanostructured Materials and Hybrid Composites for Gas Sensors and Biomedical Applications

ER -

Kim HR, Choi MG, Kim JE, Choi EY, Oh SW, Kim JH. Simple detection of binding events using an anchoring transition of liquid crystals on the immobilized oligoDNAs. In Nanostructured Materials and Hybrid Composites for Gas Sensors and Biomedical Applications. 2006. p. 47-51. (Materials Research Society Symposium Proceedings).