Serum levels of growth factors in alcohol-dependent patients according to comorbid depressive symptoms

Changwoo Han, Dong Hyun Ahn, Woong Hahm, Junghyun Nam, Yong Chon Park, Seulgi Lim, Dai Jin Kim

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Abstract

Objective: This study aims to reveal the relationship of depression with growth factors such as brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), and insulin-like growth factor-1 (IGF-1) in inpatients diagnosed with alcohol dependence, and to identify candidate growth factors as biological markers to indicate the comorbid of alcohol dependence and depression. Methods: This study examined demographic factors in 45 alcohol-dependent patients. The ADS (Korean version of the Alcohol Dependence Scale) and BDI (Korean version of Beck's Depression Inventory) were used. BDNF, NGF, and IGF-1 were measured through ELISA. Results: The average drinking quantity and the ADS score were significantly more severe in alcohol-dependent patients with depression than in those without depression. Linearly comparing BDNF, NGF, and IGF-1 with BDI values, IGF-1 was the growth factor significantly correlated with BDI scores. BDI scores were significantly correlated with ADS scores. IGF-1 was significantly higher in alcohol-dependent patients with depression. Alcohol-dependent patients with depression had greater alcohol use and more severe ADS scores. BDNF and NGF showed no significant difference between alcohol-dependent patients with and without depression, but IGF-1 was significantly higher in those with than in those without depression. Conclusion: IGF-1 was found to be associated with depression in alcohol-dependent patients, suggesting that IGF-1 in alcohol- dependent patients could be an important biomarker to indicate whether alcohol-dependence is accompanied by depression.

Original languageEnglish
Pages (from-to)43-48
Number of pages6
JournalClinical Psychopharmacology and Neuroscience
Volume14
Issue number1
DOIs
StatePublished - 2016 Jan 1

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Intercellular Signaling Peptides and Proteins
Alcohols
Depression
Somatomedins
Serum
Alcoholism
Brain-Derived Neurotrophic Factor
Nerve Growth Factor
Equipment and Supplies
Biomarkers
Drinking
Inpatients
Enzyme-Linked Immunosorbent Assay
Demography

Keywords

  • Alcohol dependence
  • Depression
  • Growth factor
  • Insulin-like growth factor-1

Cite this

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title = "Serum levels of growth factors in alcohol-dependent patients according to comorbid depressive symptoms",
abstract = "Objective: This study aims to reveal the relationship of depression with growth factors such as brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), and insulin-like growth factor-1 (IGF-1) in inpatients diagnosed with alcohol dependence, and to identify candidate growth factors as biological markers to indicate the comorbid of alcohol dependence and depression. Methods: This study examined demographic factors in 45 alcohol-dependent patients. The ADS (Korean version of the Alcohol Dependence Scale) and BDI (Korean version of Beck's Depression Inventory) were used. BDNF, NGF, and IGF-1 were measured through ELISA. Results: The average drinking quantity and the ADS score were significantly more severe in alcohol-dependent patients with depression than in those without depression. Linearly comparing BDNF, NGF, and IGF-1 with BDI values, IGF-1 was the growth factor significantly correlated with BDI scores. BDI scores were significantly correlated with ADS scores. IGF-1 was significantly higher in alcohol-dependent patients with depression. Alcohol-dependent patients with depression had greater alcohol use and more severe ADS scores. BDNF and NGF showed no significant difference between alcohol-dependent patients with and without depression, but IGF-1 was significantly higher in those with than in those without depression. Conclusion: IGF-1 was found to be associated with depression in alcohol-dependent patients, suggesting that IGF-1 in alcohol- dependent patients could be an important biomarker to indicate whether alcohol-dependence is accompanied by depression.",
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Serum levels of growth factors in alcohol-dependent patients according to comorbid depressive symptoms. / Han, Changwoo; Ahn, Dong Hyun; Hahm, Woong; Nam, Junghyun; Park, Yong Chon; Lim, Seulgi; Kim, Dai Jin.

In: Clinical Psychopharmacology and Neuroscience, Vol. 14, No. 1, 01.01.2016, p. 43-48.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Serum levels of growth factors in alcohol-dependent patients according to comorbid depressive symptoms

AU - Han, Changwoo

AU - Ahn, Dong Hyun

AU - Hahm, Woong

AU - Nam, Junghyun

AU - Park, Yong Chon

AU - Lim, Seulgi

AU - Kim, Dai Jin

PY - 2016/1/1

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N2 - Objective: This study aims to reveal the relationship of depression with growth factors such as brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), and insulin-like growth factor-1 (IGF-1) in inpatients diagnosed with alcohol dependence, and to identify candidate growth factors as biological markers to indicate the comorbid of alcohol dependence and depression. Methods: This study examined demographic factors in 45 alcohol-dependent patients. The ADS (Korean version of the Alcohol Dependence Scale) and BDI (Korean version of Beck's Depression Inventory) were used. BDNF, NGF, and IGF-1 were measured through ELISA. Results: The average drinking quantity and the ADS score were significantly more severe in alcohol-dependent patients with depression than in those without depression. Linearly comparing BDNF, NGF, and IGF-1 with BDI values, IGF-1 was the growth factor significantly correlated with BDI scores. BDI scores were significantly correlated with ADS scores. IGF-1 was significantly higher in alcohol-dependent patients with depression. Alcohol-dependent patients with depression had greater alcohol use and more severe ADS scores. BDNF and NGF showed no significant difference between alcohol-dependent patients with and without depression, but IGF-1 was significantly higher in those with than in those without depression. Conclusion: IGF-1 was found to be associated with depression in alcohol-dependent patients, suggesting that IGF-1 in alcohol- dependent patients could be an important biomarker to indicate whether alcohol-dependence is accompanied by depression.

AB - Objective: This study aims to reveal the relationship of depression with growth factors such as brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), and insulin-like growth factor-1 (IGF-1) in inpatients diagnosed with alcohol dependence, and to identify candidate growth factors as biological markers to indicate the comorbid of alcohol dependence and depression. Methods: This study examined demographic factors in 45 alcohol-dependent patients. The ADS (Korean version of the Alcohol Dependence Scale) and BDI (Korean version of Beck's Depression Inventory) were used. BDNF, NGF, and IGF-1 were measured through ELISA. Results: The average drinking quantity and the ADS score were significantly more severe in alcohol-dependent patients with depression than in those without depression. Linearly comparing BDNF, NGF, and IGF-1 with BDI values, IGF-1 was the growth factor significantly correlated with BDI scores. BDI scores were significantly correlated with ADS scores. IGF-1 was significantly higher in alcohol-dependent patients with depression. Alcohol-dependent patients with depression had greater alcohol use and more severe ADS scores. BDNF and NGF showed no significant difference between alcohol-dependent patients with and without depression, but IGF-1 was significantly higher in those with than in those without depression. Conclusion: IGF-1 was found to be associated with depression in alcohol-dependent patients, suggesting that IGF-1 in alcohol- dependent patients could be an important biomarker to indicate whether alcohol-dependence is accompanied by depression.

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