Role of IL-1α in cisplatin-induced acute renal failure in mice

Jay Wook Lee, Woo Jin Nam, Min Jee Han, Jung Ho Shin, Jin Gun Kim, Su Hyun Kim, Hye Ryoun Kim, Dong Jin Oh

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Background/Aims: For unknown reasons, caspase-1 -/- mice, protected against cisplatin-induced acute renal failure (ARF), are deficient in interleukin (IL)-1α. We thus asked whether IL-1α deficiency underlies the mechanism of protection against cisplatin-induced ARF in these mice. Methods: Cisplatin (30 mg/kg) was injected intraperitoneally into wild-type C57BL/6 mice to produce a cisplatin-induced model of ARF. IL-1α was measured in control vehicle- and cisplatin-treated wild-type animals. We also examined whether IL-1α -/- mice were similarly protected against cisplatin-induced ARF. Additionally, infiltration of CD11b- and CD49b-positive cells, as markers of macrophages, natural killer, and natural killer T cells (pan-NK cells), was investigated in wild-type and IL-1α -/- mice. Results: Compared with vehicle-treated mice, renal IL-1α increased in cisplatin-treated wild-type mice beginning on day 1. IL-1α -/- mice were shown to be protected against cisplatin-induced ARF. No significant difference in the infiltration of neutrophils or CD11b- and CD49b-positive cells were observed between wild-type and IL-1α -/- mice. Conclusions: Mice deficient in IL-1α are protected against cisplatin-induced ARF. The lack of IL-1α may explain, at least in part, the protection against cisplatin-induced ARF observed in caspase-1 -/- mice. Investigation of the protective mechanism (s) in IL-1α -/- mice in cisplatin-induced ARF merits further study.

Original languageEnglish
Pages (from-to)187-194
Number of pages8
JournalKorean Journal of Internal Medicine
Volume26
Issue number2
DOIs
StatePublished - 2011 Jun

Keywords

  • Acute kidney injury
  • Cisplatin
  • Interleukin-1alpha

Fingerprint Dive into the research topics of 'Role of IL-1α in cisplatin-induced acute renal failure in mice'. Together they form a unique fingerprint.

  • Cite this

    Lee, J. W., Nam, W. J., Han, M. J., Shin, J. H., Kim, J. G., Kim, S. H., Kim, H. R., & Oh, D. J. (2011). Role of IL-1α in cisplatin-induced acute renal failure in mice. Korean Journal of Internal Medicine, 26(2), 187-194. https://doi.org/10.3904/kjim.2011.26.2.187