Role of IL-1α in cisplatin-induced acute renal failure in mice

Jay Wook Lee, Woo Jin Nam, Min Jee Han, Jung Ho Shin, Jin Gun Kim, Su Hyun Kim, Hye Ryoun Kim, Dong Jin Oh

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Background/Aims: For unknown reasons, caspase-1 -/- mice, protected against cisplatin-induced acute renal failure (ARF), are deficient in interleukin (IL)-1α. We thus asked whether IL-1α deficiency underlies the mechanism of protection against cisplatin-induced ARF in these mice. Methods: Cisplatin (30 mg/kg) was injected intraperitoneally into wild-type C57BL/6 mice to produce a cisplatin-induced model of ARF. IL-1α was measured in control vehicle- and cisplatin-treated wild-type animals. We also examined whether IL-1α -/- mice were similarly protected against cisplatin-induced ARF. Additionally, infiltration of CD11b- and CD49b-positive cells, as markers of macrophages, natural killer, and natural killer T cells (pan-NK cells), was investigated in wild-type and IL-1α -/- mice. Results: Compared with vehicle-treated mice, renal IL-1α increased in cisplatin-treated wild-type mice beginning on day 1. IL-1α -/- mice were shown to be protected against cisplatin-induced ARF. No significant difference in the infiltration of neutrophils or CD11b- and CD49b-positive cells were observed between wild-type and IL-1α -/- mice. Conclusions: Mice deficient in IL-1α are protected against cisplatin-induced ARF. The lack of IL-1α may explain, at least in part, the protection against cisplatin-induced ARF observed in caspase-1 -/- mice. Investigation of the protective mechanism (s) in IL-1α -/- mice in cisplatin-induced ARF merits further study.

Original languageEnglish
Pages (from-to)187-194
Number of pages8
JournalKorean Journal of Internal Medicine
Volume26
Issue number2
DOIs
StatePublished - 2011 Jun 1

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Interleukin-1
Acute Kidney Injury
Cisplatin
Caspase 1
Natural Killer T-Cells
Wild Animals
Neutrophil Infiltration
Inbred C57BL Mouse
Natural Killer Cells
Macrophages
Kidney

Keywords

  • Acute kidney injury
  • Cisplatin
  • Interleukin-1alpha

Cite this

Lee, Jay Wook ; Nam, Woo Jin ; Han, Min Jee ; Shin, Jung Ho ; Kim, Jin Gun ; Kim, Su Hyun ; Kim, Hye Ryoun ; Oh, Dong Jin. / Role of IL-1α in cisplatin-induced acute renal failure in mice. In: Korean Journal of Internal Medicine. 2011 ; Vol. 26, No. 2. pp. 187-194.
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abstract = "Background/Aims: For unknown reasons, caspase-1 -/- mice, protected against cisplatin-induced acute renal failure (ARF), are deficient in interleukin (IL)-1α. We thus asked whether IL-1α deficiency underlies the mechanism of protection against cisplatin-induced ARF in these mice. Methods: Cisplatin (30 mg/kg) was injected intraperitoneally into wild-type C57BL/6 mice to produce a cisplatin-induced model of ARF. IL-1α was measured in control vehicle- and cisplatin-treated wild-type animals. We also examined whether IL-1α -/- mice were similarly protected against cisplatin-induced ARF. Additionally, infiltration of CD11b- and CD49b-positive cells, as markers of macrophages, natural killer, and natural killer T cells (pan-NK cells), was investigated in wild-type and IL-1α -/- mice. Results: Compared with vehicle-treated mice, renal IL-1α increased in cisplatin-treated wild-type mice beginning on day 1. IL-1α -/- mice were shown to be protected against cisplatin-induced ARF. No significant difference in the infiltration of neutrophils or CD11b- and CD49b-positive cells were observed between wild-type and IL-1α -/- mice. Conclusions: Mice deficient in IL-1α are protected against cisplatin-induced ARF. The lack of IL-1α may explain, at least in part, the protection against cisplatin-induced ARF observed in caspase-1 -/- mice. Investigation of the protective mechanism (s) in IL-1α -/- mice in cisplatin-induced ARF merits further study.",
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Lee, JW, Nam, WJ, Han, MJ, Shin, JH, Kim, JG, Kim, SH, Kim, HR & Oh, DJ 2011, 'Role of IL-1α in cisplatin-induced acute renal failure in mice', Korean Journal of Internal Medicine, vol. 26, no. 2, pp. 187-194. https://doi.org/10.3904/kjim.2011.26.2.187

Role of IL-1α in cisplatin-induced acute renal failure in mice. / Lee, Jay Wook; Nam, Woo Jin; Han, Min Jee; Shin, Jung Ho; Kim, Jin Gun; Kim, Su Hyun; Kim, Hye Ryoun; Oh, Dong Jin.

In: Korean Journal of Internal Medicine, Vol. 26, No. 2, 01.06.2011, p. 187-194.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Role of IL-1α in cisplatin-induced acute renal failure in mice

AU - Lee, Jay Wook

AU - Nam, Woo Jin

AU - Han, Min Jee

AU - Shin, Jung Ho

AU - Kim, Jin Gun

AU - Kim, Su Hyun

AU - Kim, Hye Ryoun

AU - Oh, Dong Jin

PY - 2011/6/1

Y1 - 2011/6/1

N2 - Background/Aims: For unknown reasons, caspase-1 -/- mice, protected against cisplatin-induced acute renal failure (ARF), are deficient in interleukin (IL)-1α. We thus asked whether IL-1α deficiency underlies the mechanism of protection against cisplatin-induced ARF in these mice. Methods: Cisplatin (30 mg/kg) was injected intraperitoneally into wild-type C57BL/6 mice to produce a cisplatin-induced model of ARF. IL-1α was measured in control vehicle- and cisplatin-treated wild-type animals. We also examined whether IL-1α -/- mice were similarly protected against cisplatin-induced ARF. Additionally, infiltration of CD11b- and CD49b-positive cells, as markers of macrophages, natural killer, and natural killer T cells (pan-NK cells), was investigated in wild-type and IL-1α -/- mice. Results: Compared with vehicle-treated mice, renal IL-1α increased in cisplatin-treated wild-type mice beginning on day 1. IL-1α -/- mice were shown to be protected against cisplatin-induced ARF. No significant difference in the infiltration of neutrophils or CD11b- and CD49b-positive cells were observed between wild-type and IL-1α -/- mice. Conclusions: Mice deficient in IL-1α are protected against cisplatin-induced ARF. The lack of IL-1α may explain, at least in part, the protection against cisplatin-induced ARF observed in caspase-1 -/- mice. Investigation of the protective mechanism (s) in IL-1α -/- mice in cisplatin-induced ARF merits further study.

AB - Background/Aims: For unknown reasons, caspase-1 -/- mice, protected against cisplatin-induced acute renal failure (ARF), are deficient in interleukin (IL)-1α. We thus asked whether IL-1α deficiency underlies the mechanism of protection against cisplatin-induced ARF in these mice. Methods: Cisplatin (30 mg/kg) was injected intraperitoneally into wild-type C57BL/6 mice to produce a cisplatin-induced model of ARF. IL-1α was measured in control vehicle- and cisplatin-treated wild-type animals. We also examined whether IL-1α -/- mice were similarly protected against cisplatin-induced ARF. Additionally, infiltration of CD11b- and CD49b-positive cells, as markers of macrophages, natural killer, and natural killer T cells (pan-NK cells), was investigated in wild-type and IL-1α -/- mice. Results: Compared with vehicle-treated mice, renal IL-1α increased in cisplatin-treated wild-type mice beginning on day 1. IL-1α -/- mice were shown to be protected against cisplatin-induced ARF. No significant difference in the infiltration of neutrophils or CD11b- and CD49b-positive cells were observed between wild-type and IL-1α -/- mice. Conclusions: Mice deficient in IL-1α are protected against cisplatin-induced ARF. The lack of IL-1α may explain, at least in part, the protection against cisplatin-induced ARF observed in caspase-1 -/- mice. Investigation of the protective mechanism (s) in IL-1α -/- mice in cisplatin-induced ARF merits further study.

KW - Acute kidney injury

KW - Cisplatin

KW - Interleukin-1alpha

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