RNT-1 regulation in C. elegans

Yon Ju Ji, Gunasekaran Singaravelu, Joohong Ahnn

Research output: Contribution to journalReview article

3 Citations (Scopus)

Abstract

RUNXs are important transcription factors, which are involved in animal development and human carcinogenesis. RNT-1, the only homologue of RUNXs, in Caenorhabditis elegans (C. elegans) has been identified and viable mutant animals of rnt-1 gene have been isolated and characterized recently. Genetic analyses using rnf-1 mutants have shown that RNT-1 is regulated by TGFβ- and Wnt-signaling pathways in the body size regulation and male tail development. Here, we review our current understanding of RNT-1 functions in these signaling pathways. Furthermore, future prospects of RNT-1 and BRO-1 studies in C. elegans are discussed in this review.

Original languageEnglish
Pages (from-to)8-15
Number of pages8
JournalJournal of Cellular Biochemistry
Volume96
Issue number1
DOIs
StatePublished - 2005 Sep 1

Fingerprint

Caenorhabditis elegans
Animals
Wnt Signaling Pathway
Body Size
Human Development
Tail
Carcinogenesis
Transcription Factors
Genes

Keywords

  • Body size
  • Male tail abnormality
  • Runx
  • TGFβ
  • Wnt
  • bro-1
  • rnt-1

Cite this

Ji, Yon Ju ; Singaravelu, Gunasekaran ; Ahnn, Joohong. / RNT-1 regulation in C. elegans. In: Journal of Cellular Biochemistry. 2005 ; Vol. 96, No. 1. pp. 8-15.
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RNT-1 regulation in C. elegans. / Ji, Yon Ju; Singaravelu, Gunasekaran; Ahnn, Joohong.

In: Journal of Cellular Biochemistry, Vol. 96, No. 1, 01.09.2005, p. 8-15.

Research output: Contribution to journalReview article

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