Reversal of oxidative stress in endothelial cells by controlled release of adiponectin

Mohanad Mossalam, Ji Hoon Jeong, E. Dale Abel, Sung Wan Kim, Yong-Hee Kim

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Hyperglycemia causes endothelial dysfunction due to its effect on increasing reactive oxygen species (ROS). Adiponectin (Adp) has been reported to suppress hyperglycemia-associated ROS generation. It was hypothesized that administering globular adiponectin (gAdp) via injectable biodegradable thermosensitive triblock copolymer might effectively reduce ROS generation in endothelial cells. In this study, gAdp was incorporated into and released from the polymer gel. The released gAdp was further investigated by comparing it with the intact gAdp with regard to the efficiency in reducing ROS and activating cAMP. The released gAdp effectively suppressed excess ROS production in the in vitro endothelial cell culture model under high-glucose condition via cAMP/PKA pathway. These data provide a rationale for developing controlled release dosage form of gAdp as a therapeutic tool for oxidative stress-related pathology in patients with diabetes.

Original languageEnglish
Pages (from-to)234-237
Number of pages4
JournalJournal of Controlled Release
Volume130
Issue number3
DOIs
StatePublished - 2008 Sep 24

Keywords

  • Adiponectin
  • Controlled release
  • Endothelial cells
  • Oxidative stress

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