Regenerative medicine of the bile duct: Beyond the myth

Elina Maria Buisson, Jaemin Jeong, Han Joon Kim, Dongho Choi

Research output: Contribution to journalReview article

Abstract

Cholangiopathies are rare diseases of the bile duct with high mortality rates. The current treatment for cholangiopathies is liver transplantation, but there are significant obstacles including a shortage of donors and a high risk of complications. Currently, there is only one available medicine on the market targeting cholangiopathies, and the results have been inadequate in clinical therapy. To overcome these obstacles, many researchers have used human induced pluripotent stem cells (hPSC) as a source for cholangiocyte-like cell generation and have incorporated advances in bioprinting to create artificial bile ducts for implantation and transplantation. This has allowed the field to move dramatically forward in studies of biliary regenerative medicine. In this review, the authors provide an overview of cholangiocytes, the organogenesis of the bile duct, cholangiopathies, and the current treatment and advances that have been made that are opening new doors to the study of cholangiopathies.

Original languageEnglish
Pages (from-to)183-194
Number of pages12
JournalInternational Journal of Stem Cells
Volume12
Issue number2
DOIs
StatePublished - 2019 Jan 1

Fingerprint

Regenerative Medicine
Bile Ducts
Bioprinting
Induced Pluripotent Stem Cells
Organogenesis
Rare Diseases
Liver Transplantation
Therapeutics
Transplantation
Research Personnel
Medicine
Mortality

Keywords

  • Biliary regeneration
  • Bioprinting
  • Cholangiocytes
  • Cholangiopathies
  • Human derived pluripotent stem cells
  • Stem cell therapy

Cite this

Buisson, Elina Maria ; Jeong, Jaemin ; Kim, Han Joon ; Choi, Dongho. / Regenerative medicine of the bile duct : Beyond the myth. In: International Journal of Stem Cells. 2019 ; Vol. 12, No. 2. pp. 183-194.
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Regenerative medicine of the bile duct : Beyond the myth. / Buisson, Elina Maria; Jeong, Jaemin; Kim, Han Joon; Choi, Dongho.

In: International Journal of Stem Cells, Vol. 12, No. 2, 01.01.2019, p. 183-194.

Research output: Contribution to journalReview article

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