Prognostic significance of neuroendocrine components in gastric carcinomas

Ji Y. Park, Min Hee Ryu, Young Soo Park, Hye Jin Park, Baek Yeol Ryoo, MinGyu Kim, Jeong Hwan Yook, Byung Sik Kim, Yoon Koo Kang

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Background Gastric neuroendocrine carcinomas (NECs) and mixed adenoneuroendocrine carcinomas (MANECs) are aggressive tumours but the prognostic significance of a neuroendocrine component in <30% of the tumour remains unclear. Here, the implication of neuroendocrine components in gastric carcinomas was assessed according to proportion. Methods Surgically resected primary gastric carcinomas with neuroendocrine morphology (NEM; n = 88) from 2000 to 2012 at Asan Medical Center were retrospectively reviewed. Neuroendocrine differentiation (NED) was defined as immunopositivity for one of three neuroendocrine markers (synaptophysin, chromogranin or CD56) within the NEM area. To validate the prognostic significance of NED, these cases were compared with 650 randomly selected gastric adenocarcinomas without NEM from the same time period. Results Gastric carcinomas with NEM were reclassified as NEC (≥70% NED, n = 47), MANEC (30-70% NED, n = 10), gastric carcinoma with 10-30% NED (GCNED, n = 8) and carcinoma with <10% NED (n = 23). The survival rates of patients with ≥10% NED were significantly poorer than those with <10% NED but no survival difference was observed between NEC and MANEC. In univariate analyses, older age (≥60 years), larger tumour size (≥4 cm), advanced stage group, ≥10% NED and lymphovascular or perineural invasion were indicative of a poor prognosis. Stage group and ≥10% NED remained as independent prognostic factors by multivariate analysis. Conclusions A minor proportion (10-30%) of NED should not be overlooked in gastric carcinomas with NEM. NED should be carefully evaluated to predict patient outcomes and plan optimal additional therapies.

Original languageEnglish
Pages (from-to)2802-2809
Number of pages8
JournalEuropean Journal of Cancer
Volume50
Issue number16
DOIs
StatePublished - 2014 Jan 1

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Stomach
Carcinoma
Neuroendocrine Carcinoma
Chromogranins
Neoplasms
Synaptophysin
Statistical Factor Analysis
Adenocarcinoma
Multivariate Analysis
Survival Rate
Survival

Keywords

  • Component
  • Gastric carcinoma
  • Neuroendocrine
  • Prognosis
  • Proportion

Cite this

Park, J. Y., Ryu, M. H., Park, Y. S., Park, H. J., Ryoo, B. Y., Kim, M., ... Kang, Y. K. (2014). Prognostic significance of neuroendocrine components in gastric carcinomas. European Journal of Cancer, 50(16), 2802-2809. https://doi.org/10.1016/j.ejca.2014.08.004
Park, Ji Y. ; Ryu, Min Hee ; Park, Young Soo ; Park, Hye Jin ; Ryoo, Baek Yeol ; Kim, MinGyu ; Yook, Jeong Hwan ; Kim, Byung Sik ; Kang, Yoon Koo. / Prognostic significance of neuroendocrine components in gastric carcinomas. In: European Journal of Cancer. 2014 ; Vol. 50, No. 16. pp. 2802-2809.
@article{0ebd8c97e7b942319fa3aef6991c33b1,
title = "Prognostic significance of neuroendocrine components in gastric carcinomas",
abstract = "Background Gastric neuroendocrine carcinomas (NECs) and mixed adenoneuroendocrine carcinomas (MANECs) are aggressive tumours but the prognostic significance of a neuroendocrine component in <30{\%} of the tumour remains unclear. Here, the implication of neuroendocrine components in gastric carcinomas was assessed according to proportion. Methods Surgically resected primary gastric carcinomas with neuroendocrine morphology (NEM; n = 88) from 2000 to 2012 at Asan Medical Center were retrospectively reviewed. Neuroendocrine differentiation (NED) was defined as immunopositivity for one of three neuroendocrine markers (synaptophysin, chromogranin or CD56) within the NEM area. To validate the prognostic significance of NED, these cases were compared with 650 randomly selected gastric adenocarcinomas without NEM from the same time period. Results Gastric carcinomas with NEM were reclassified as NEC (≥70{\%} NED, n = 47), MANEC (30-70{\%} NED, n = 10), gastric carcinoma with 10-30{\%} NED (GCNED, n = 8) and carcinoma with <10{\%} NED (n = 23). The survival rates of patients with ≥10{\%} NED were significantly poorer than those with <10{\%} NED but no survival difference was observed between NEC and MANEC. In univariate analyses, older age (≥60 years), larger tumour size (≥4 cm), advanced stage group, ≥10{\%} NED and lymphovascular or perineural invasion were indicative of a poor prognosis. Stage group and ≥10{\%} NED remained as independent prognostic factors by multivariate analysis. Conclusions A minor proportion (10-30{\%}) of NED should not be overlooked in gastric carcinomas with NEM. NED should be carefully evaluated to predict patient outcomes and plan optimal additional therapies.",
keywords = "Component, Gastric carcinoma, Neuroendocrine, Prognosis, Proportion",
author = "Park, {Ji Y.} and Ryu, {Min Hee} and Park, {Young Soo} and Park, {Hye Jin} and Ryoo, {Baek Yeol} and MinGyu Kim and Yook, {Jeong Hwan} and Kim, {Byung Sik} and Kang, {Yoon Koo}",
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Park, JY, Ryu, MH, Park, YS, Park, HJ, Ryoo, BY, Kim, M, Yook, JH, Kim, BS & Kang, YK 2014, 'Prognostic significance of neuroendocrine components in gastric carcinomas', European Journal of Cancer, vol. 50, no. 16, pp. 2802-2809. https://doi.org/10.1016/j.ejca.2014.08.004

Prognostic significance of neuroendocrine components in gastric carcinomas. / Park, Ji Y.; Ryu, Min Hee; Park, Young Soo; Park, Hye Jin; Ryoo, Baek Yeol; Kim, MinGyu; Yook, Jeong Hwan; Kim, Byung Sik; Kang, Yoon Koo.

In: European Journal of Cancer, Vol. 50, No. 16, 01.01.2014, p. 2802-2809.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Prognostic significance of neuroendocrine components in gastric carcinomas

AU - Park, Ji Y.

AU - Ryu, Min Hee

AU - Park, Young Soo

AU - Park, Hye Jin

AU - Ryoo, Baek Yeol

AU - Kim, MinGyu

AU - Yook, Jeong Hwan

AU - Kim, Byung Sik

AU - Kang, Yoon Koo

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Background Gastric neuroendocrine carcinomas (NECs) and mixed adenoneuroendocrine carcinomas (MANECs) are aggressive tumours but the prognostic significance of a neuroendocrine component in <30% of the tumour remains unclear. Here, the implication of neuroendocrine components in gastric carcinomas was assessed according to proportion. Methods Surgically resected primary gastric carcinomas with neuroendocrine morphology (NEM; n = 88) from 2000 to 2012 at Asan Medical Center were retrospectively reviewed. Neuroendocrine differentiation (NED) was defined as immunopositivity for one of three neuroendocrine markers (synaptophysin, chromogranin or CD56) within the NEM area. To validate the prognostic significance of NED, these cases were compared with 650 randomly selected gastric adenocarcinomas without NEM from the same time period. Results Gastric carcinomas with NEM were reclassified as NEC (≥70% NED, n = 47), MANEC (30-70% NED, n = 10), gastric carcinoma with 10-30% NED (GCNED, n = 8) and carcinoma with <10% NED (n = 23). The survival rates of patients with ≥10% NED were significantly poorer than those with <10% NED but no survival difference was observed between NEC and MANEC. In univariate analyses, older age (≥60 years), larger tumour size (≥4 cm), advanced stage group, ≥10% NED and lymphovascular or perineural invasion were indicative of a poor prognosis. Stage group and ≥10% NED remained as independent prognostic factors by multivariate analysis. Conclusions A minor proportion (10-30%) of NED should not be overlooked in gastric carcinomas with NEM. NED should be carefully evaluated to predict patient outcomes and plan optimal additional therapies.

AB - Background Gastric neuroendocrine carcinomas (NECs) and mixed adenoneuroendocrine carcinomas (MANECs) are aggressive tumours but the prognostic significance of a neuroendocrine component in <30% of the tumour remains unclear. Here, the implication of neuroendocrine components in gastric carcinomas was assessed according to proportion. Methods Surgically resected primary gastric carcinomas with neuroendocrine morphology (NEM; n = 88) from 2000 to 2012 at Asan Medical Center were retrospectively reviewed. Neuroendocrine differentiation (NED) was defined as immunopositivity for one of three neuroendocrine markers (synaptophysin, chromogranin or CD56) within the NEM area. To validate the prognostic significance of NED, these cases were compared with 650 randomly selected gastric adenocarcinomas without NEM from the same time period. Results Gastric carcinomas with NEM were reclassified as NEC (≥70% NED, n = 47), MANEC (30-70% NED, n = 10), gastric carcinoma with 10-30% NED (GCNED, n = 8) and carcinoma with <10% NED (n = 23). The survival rates of patients with ≥10% NED were significantly poorer than those with <10% NED but no survival difference was observed between NEC and MANEC. In univariate analyses, older age (≥60 years), larger tumour size (≥4 cm), advanced stage group, ≥10% NED and lymphovascular or perineural invasion were indicative of a poor prognosis. Stage group and ≥10% NED remained as independent prognostic factors by multivariate analysis. Conclusions A minor proportion (10-30%) of NED should not be overlooked in gastric carcinomas with NEM. NED should be carefully evaluated to predict patient outcomes and plan optimal additional therapies.

KW - Component

KW - Gastric carcinoma

KW - Neuroendocrine

KW - Prognosis

KW - Proportion

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DO - 10.1016/j.ejca.2014.08.004

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