Prognostic factors in gastric cancer patients with peritoneal carcinomatosis

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Purpose: Peritoneal carcinomatosis (PC) has a dismal prognosis and is occasionally encountered during initial exploration in patients with gastric cancer. The clinicopathological characteristics and survival were analyzed in patients with gastric cancer and PC. Materials and Methods: Among 2,083 gastric cancer patients who received surgery at the department of surgery, Hanyang University Hospital from 1992 to 2009, 130 patients revealed PC. Ten patients who were lost during follow-up were excluded. The remaining 120 patients were divided into three groups according to the type of surgery. The degree of PC was classified into P1(to the adjacent peritoneum) and P2 (to the distant peritoneum). Various other clinicopathological factors were analyzed using univariate and multivariate survival analyses. Results: Systemic chemotherapy (SC), type of surgery, lymph node dissection, degree of PC, and presence of ascites were significant prognostic factors. However, age, gender, resection of PC, and Borrmann type were not significant prognostic factors. In a multivariate analysis, SC and the degree of PC were independent prognostic factors. The survival benefit of SC was significant without reference to the type of surgery or degree of PC. Conclusions: A gastrectomy should be considered feasible in patients with gastric cancer and PC. The independent favorable prognostic factors were SC and a low degree of PC. SC improved the prognosis regardless of operation type and degree of PC.

Original languageEnglish
Pages (from-to)126-132
Number of pages7
JournalJournal of Gastric Cancer
Volume10
Issue number3
DOIs
StatePublished - 2010 Dec 1

Fingerprint

Stomach Neoplasms
Carcinoma
Drug Therapy
Peritoneum
Multivariate Analysis
Survival
Gastrectomy
Survival Analysis
Lymph Node Excision
Ascites

Keywords

  • Gastric cancer
  • Peritoneal carcinomatosis
  • Prognostic factor

Cite this

@article{a6aa2e0101e949b89d0d7f0641d02ed7,
title = "Prognostic factors in gastric cancer patients with peritoneal carcinomatosis",
abstract = "Purpose: Peritoneal carcinomatosis (PC) has a dismal prognosis and is occasionally encountered during initial exploration in patients with gastric cancer. The clinicopathological characteristics and survival were analyzed in patients with gastric cancer and PC. Materials and Methods: Among 2,083 gastric cancer patients who received surgery at the department of surgery, Hanyang University Hospital from 1992 to 2009, 130 patients revealed PC. Ten patients who were lost during follow-up were excluded. The remaining 120 patients were divided into three groups according to the type of surgery. The degree of PC was classified into P1(to the adjacent peritoneum) and P2 (to the distant peritoneum). Various other clinicopathological factors were analyzed using univariate and multivariate survival analyses. Results: Systemic chemotherapy (SC), type of surgery, lymph node dissection, degree of PC, and presence of ascites were significant prognostic factors. However, age, gender, resection of PC, and Borrmann type were not significant prognostic factors. In a multivariate analysis, SC and the degree of PC were independent prognostic factors. The survival benefit of SC was significant without reference to the type of surgery or degree of PC. Conclusions: A gastrectomy should be considered feasible in patients with gastric cancer and PC. The independent favorable prognostic factors were SC and a low degree of PC. SC improved the prognosis regardless of operation type and degree of PC.",
keywords = "Gastric cancer, Peritoneal carcinomatosis, Prognostic factor",
author = "Kim, {Hyun Il} and Ha, {Tae Kyung} and Kwon, {Sung Joon}",
year = "2010",
month = "12",
day = "1",
doi = "10.5230/jgc.2010.10.3.126",
language = "English",
volume = "10",
pages = "126--132",
journal = "Journal of Gastric Cancer",
issn = "2093-582X",
number = "3",

}

Prognostic factors in gastric cancer patients with peritoneal carcinomatosis. / Kim, Hyun Il; Ha, Tae Kyung; Kwon, Sung Joon.

In: Journal of Gastric Cancer, Vol. 10, No. 3, 01.12.2010, p. 126-132.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Prognostic factors in gastric cancer patients with peritoneal carcinomatosis

AU - Kim, Hyun Il

AU - Ha, Tae Kyung

AU - Kwon, Sung Joon

PY - 2010/12/1

Y1 - 2010/12/1

N2 - Purpose: Peritoneal carcinomatosis (PC) has a dismal prognosis and is occasionally encountered during initial exploration in patients with gastric cancer. The clinicopathological characteristics and survival were analyzed in patients with gastric cancer and PC. Materials and Methods: Among 2,083 gastric cancer patients who received surgery at the department of surgery, Hanyang University Hospital from 1992 to 2009, 130 patients revealed PC. Ten patients who were lost during follow-up were excluded. The remaining 120 patients were divided into three groups according to the type of surgery. The degree of PC was classified into P1(to the adjacent peritoneum) and P2 (to the distant peritoneum). Various other clinicopathological factors were analyzed using univariate and multivariate survival analyses. Results: Systemic chemotherapy (SC), type of surgery, lymph node dissection, degree of PC, and presence of ascites were significant prognostic factors. However, age, gender, resection of PC, and Borrmann type were not significant prognostic factors. In a multivariate analysis, SC and the degree of PC were independent prognostic factors. The survival benefit of SC was significant without reference to the type of surgery or degree of PC. Conclusions: A gastrectomy should be considered feasible in patients with gastric cancer and PC. The independent favorable prognostic factors were SC and a low degree of PC. SC improved the prognosis regardless of operation type and degree of PC.

AB - Purpose: Peritoneal carcinomatosis (PC) has a dismal prognosis and is occasionally encountered during initial exploration in patients with gastric cancer. The clinicopathological characteristics and survival were analyzed in patients with gastric cancer and PC. Materials and Methods: Among 2,083 gastric cancer patients who received surgery at the department of surgery, Hanyang University Hospital from 1992 to 2009, 130 patients revealed PC. Ten patients who were lost during follow-up were excluded. The remaining 120 patients were divided into three groups according to the type of surgery. The degree of PC was classified into P1(to the adjacent peritoneum) and P2 (to the distant peritoneum). Various other clinicopathological factors were analyzed using univariate and multivariate survival analyses. Results: Systemic chemotherapy (SC), type of surgery, lymph node dissection, degree of PC, and presence of ascites were significant prognostic factors. However, age, gender, resection of PC, and Borrmann type were not significant prognostic factors. In a multivariate analysis, SC and the degree of PC were independent prognostic factors. The survival benefit of SC was significant without reference to the type of surgery or degree of PC. Conclusions: A gastrectomy should be considered feasible in patients with gastric cancer and PC. The independent favorable prognostic factors were SC and a low degree of PC. SC improved the prognosis regardless of operation type and degree of PC.

KW - Gastric cancer

KW - Peritoneal carcinomatosis

KW - Prognostic factor

UR - http://www.scopus.com/inward/record.url?scp=84867492184&partnerID=8YFLogxK

U2 - 10.5230/jgc.2010.10.3.126

DO - 10.5230/jgc.2010.10.3.126

M3 - Article

AN - SCOPUS:84867492184

VL - 10

SP - 126

EP - 132

JO - Journal of Gastric Cancer

JF - Journal of Gastric Cancer

SN - 2093-582X

IS - 3

ER -