Pharmacotherapy of irritable bowel syndrome

Research output: Contribution to journalReview article

Abstract

Irritable bowel syndrome is a group of symptoms that includes abdominal pain and changes in the form and frequency of stool. Since its symptoms are usually long-lasting, the disease significantly degrades quality of life. Several pharmacological therapies have been suggested according to the type of symptoms (e.g., abdominal pain, constipation, or diarrhea). In order to control abdominal pain, smooth muscle antispasmodics, antidepressants including tricyclic antidepressants and selective serotonin reuptake inhibitors, or 5-HT3 antagonists can be used. To improve constipation, dietary fiber or laxatives, 5-HT4 agonists, and chloride channel activators are available. Opioid agonists, mixed opioid agonists/antagonists such as eluxadoline, and bile salt sequestrants can be considered for diarrhea. In addition, probiotics and non-absorbable oral antibiotics can be used for the normalization of the gut microbiome and the treatment of small intestinal bacterial overgrowth, respectively. It is necessary to understand the characteristics of each drug and their combinations, because any single regimen cannot improve all symptoms in patients with irritable bowel syndrome. In this review, the mechanisms of action, efficacy, and adverse events associated with drugs used for irritable bowel syndrome are summarized.

Original languageEnglish
Pages (from-to)57-62
Number of pages6
JournalJournal of the Korean Medical Association
Volume60
Issue number1
DOIs
StatePublished - 2017 Jan 1

Fingerprint

Irritable Bowel Syndrome
Abdominal Pain
Constipation
Drug Therapy
Opioid Analgesics
Diarrhea
Serotonin 5-HT4 Receptor Agonists
Serotonin 5-HT3 Receptor Antagonists
Parasympatholytics
Laxatives
Tricyclic Antidepressive Agents
Serotonin Uptake Inhibitors
Probiotics
Dietary Fiber
Drug Combinations
Bile Acids and Salts
Antidepressive Agents
Smooth Muscle
Quality of Life
Pharmacology

Keywords

  • Drug therapy
  • Irritable bowel syndrome

Cite this

@article{36d0bbefe66d41c381cdf3bb2c61ad22,
title = "Pharmacotherapy of irritable bowel syndrome",
abstract = "Irritable bowel syndrome is a group of symptoms that includes abdominal pain and changes in the form and frequency of stool. Since its symptoms are usually long-lasting, the disease significantly degrades quality of life. Several pharmacological therapies have been suggested according to the type of symptoms (e.g., abdominal pain, constipation, or diarrhea). In order to control abdominal pain, smooth muscle antispasmodics, antidepressants including tricyclic antidepressants and selective serotonin reuptake inhibitors, or 5-HT3 antagonists can be used. To improve constipation, dietary fiber or laxatives, 5-HT4 agonists, and chloride channel activators are available. Opioid agonists, mixed opioid agonists/antagonists such as eluxadoline, and bile salt sequestrants can be considered for diarrhea. In addition, probiotics and non-absorbable oral antibiotics can be used for the normalization of the gut microbiome and the treatment of small intestinal bacterial overgrowth, respectively. It is necessary to understand the characteristics of each drug and their combinations, because any single regimen cannot improve all symptoms in patients with irritable bowel syndrome. In this review, the mechanisms of action, efficacy, and adverse events associated with drugs used for irritable bowel syndrome are summarized.",
keywords = "Drug therapy, Irritable bowel syndrome",
author = "Park, {Chan Hyuk} and Han, {Dong Soo}",
year = "2017",
month = "1",
day = "1",
doi = "10.5124/jkma.2017.60.1.57",
language = "English",
volume = "60",
pages = "57--62",
journal = "Journal of the Korean Medical Association",
issn = "1975-8456",
number = "1",

}

Pharmacotherapy of irritable bowel syndrome. / Park, Chan Hyuk; Han, Dong Soo.

In: Journal of the Korean Medical Association, Vol. 60, No. 1, 01.01.2017, p. 57-62.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Pharmacotherapy of irritable bowel syndrome

AU - Park, Chan Hyuk

AU - Han, Dong Soo

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Irritable bowel syndrome is a group of symptoms that includes abdominal pain and changes in the form and frequency of stool. Since its symptoms are usually long-lasting, the disease significantly degrades quality of life. Several pharmacological therapies have been suggested according to the type of symptoms (e.g., abdominal pain, constipation, or diarrhea). In order to control abdominal pain, smooth muscle antispasmodics, antidepressants including tricyclic antidepressants and selective serotonin reuptake inhibitors, or 5-HT3 antagonists can be used. To improve constipation, dietary fiber or laxatives, 5-HT4 agonists, and chloride channel activators are available. Opioid agonists, mixed opioid agonists/antagonists such as eluxadoline, and bile salt sequestrants can be considered for diarrhea. In addition, probiotics and non-absorbable oral antibiotics can be used for the normalization of the gut microbiome and the treatment of small intestinal bacterial overgrowth, respectively. It is necessary to understand the characteristics of each drug and their combinations, because any single regimen cannot improve all symptoms in patients with irritable bowel syndrome. In this review, the mechanisms of action, efficacy, and adverse events associated with drugs used for irritable bowel syndrome are summarized.

AB - Irritable bowel syndrome is a group of symptoms that includes abdominal pain and changes in the form and frequency of stool. Since its symptoms are usually long-lasting, the disease significantly degrades quality of life. Several pharmacological therapies have been suggested according to the type of symptoms (e.g., abdominal pain, constipation, or diarrhea). In order to control abdominal pain, smooth muscle antispasmodics, antidepressants including tricyclic antidepressants and selective serotonin reuptake inhibitors, or 5-HT3 antagonists can be used. To improve constipation, dietary fiber or laxatives, 5-HT4 agonists, and chloride channel activators are available. Opioid agonists, mixed opioid agonists/antagonists such as eluxadoline, and bile salt sequestrants can be considered for diarrhea. In addition, probiotics and non-absorbable oral antibiotics can be used for the normalization of the gut microbiome and the treatment of small intestinal bacterial overgrowth, respectively. It is necessary to understand the characteristics of each drug and their combinations, because any single regimen cannot improve all symptoms in patients with irritable bowel syndrome. In this review, the mechanisms of action, efficacy, and adverse events associated with drugs used for irritable bowel syndrome are summarized.

KW - Drug therapy

KW - Irritable bowel syndrome

UR - http://www.scopus.com/inward/record.url?scp=85013399288&partnerID=8YFLogxK

U2 - 10.5124/jkma.2017.60.1.57

DO - 10.5124/jkma.2017.60.1.57

M3 - Review article

AN - SCOPUS:85013399288

VL - 60

SP - 57

EP - 62

JO - Journal of the Korean Medical Association

JF - Journal of the Korean Medical Association

SN - 1975-8456

IS - 1

ER -