Patterns of skin and soft tissue metastases from breast cancer according to subtypes: Relationship between egfr overexpression and skin manifestations

Jee Hyun Kong, Yeon Hee Park, Jung A. Kim, Jeong Hoon Kim, Jina Yun, Jong Mu Sun, Young-Woong Won, Soohyeon Lee, Seung Tae Kim, Eun Yoon Cho, Jin Seok Ahn, Young Hyuck Im

Research output: Contribution to journalReview article

12 Citations (Scopus)

Abstract

Objectives: We evaluated whether skin changes and soft tissue infiltration patterns reflect breast cancer subtypes based on the breast hormonal receptor (HR) and human epidermal growth factor receptor 2 (HER2) status at the time of skin metastasis. Methods: We retrospectively reviewed the patients' medical records with radiologic imaging studies. Results: The numbers of patients of each subtype were as follows: HR positive (HR+ve) 53 (42.4%), HER2 enriched 43 (34.4%), and triple negative (TN) 29 (23.2%). The presence of skin ulceration was found more commonly in the HR+ve group than in the others (57.1% for HR+ve vs. 25% for HER2 enriched vs. 15.4% for TN, p = 0.019). Erythematous infiltrations were shown predominantly in the TN group (19.0 vs. 54.2 vs. 84.6%, respectively, p < 0.000). On CT scans, soft tissue infiltration appeared to be more common in the HER2-enriched and TN groups than in the HR+ve group (24.5 vs. 41.9 vs. 48.3%, respectively, p = 0.013). Erythematous infiltrative lesions were more common in patients with epidermal growth factor receptor overexpression (p = 0.036). Conclusion: The patterns of skin involvement including surrounding soft tissue infiltration may reflect breast cancer subtype. Prospective evaluation is necessary to confirm their influential effect on breast cancer subtypes.

Original languageEnglish
Pages (from-to)55-62
Number of pages8
JournalOncology
Volume81
Issue number1
DOIs
StatePublished - 2011 Sep 1

Fingerprint

Skin Manifestations
Breast Neoplasms
Neoplasm Metastasis
Skin
Epidermal Growth Factor Receptor
Medical Records
Breast
human ERBB2 protein

Keywords

  • Breast cancer
  • Hormonal receptor
  • Human epidermal growth factor receptor 2
  • Skin changes
  • Soft tissue infiltration

Cite this

Kong, Jee Hyun ; Park, Yeon Hee ; Kim, Jung A. ; Kim, Jeong Hoon ; Yun, Jina ; Sun, Jong Mu ; Won, Young-Woong ; Lee, Soohyeon ; Kim, Seung Tae ; Cho, Eun Yoon ; Ahn, Jin Seok ; Im, Young Hyuck. / Patterns of skin and soft tissue metastases from breast cancer according to subtypes : Relationship between egfr overexpression and skin manifestations. In: Oncology. 2011 ; Vol. 81, No. 1. pp. 55-62.
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title = "Patterns of skin and soft tissue metastases from breast cancer according to subtypes: Relationship between egfr overexpression and skin manifestations",
abstract = "Objectives: We evaluated whether skin changes and soft tissue infiltration patterns reflect breast cancer subtypes based on the breast hormonal receptor (HR) and human epidermal growth factor receptor 2 (HER2) status at the time of skin metastasis. Methods: We retrospectively reviewed the patients' medical records with radiologic imaging studies. Results: The numbers of patients of each subtype were as follows: HR positive (HR+ve) 53 (42.4{\%}), HER2 enriched 43 (34.4{\%}), and triple negative (TN) 29 (23.2{\%}). The presence of skin ulceration was found more commonly in the HR+ve group than in the others (57.1{\%} for HR+ve vs. 25{\%} for HER2 enriched vs. 15.4{\%} for TN, p = 0.019). Erythematous infiltrations were shown predominantly in the TN group (19.0 vs. 54.2 vs. 84.6{\%}, respectively, p < 0.000). On CT scans, soft tissue infiltration appeared to be more common in the HER2-enriched and TN groups than in the HR+ve group (24.5 vs. 41.9 vs. 48.3{\%}, respectively, p = 0.013). Erythematous infiltrative lesions were more common in patients with epidermal growth factor receptor overexpression (p = 0.036). Conclusion: The patterns of skin involvement including surrounding soft tissue infiltration may reflect breast cancer subtype. Prospective evaluation is necessary to confirm their influential effect on breast cancer subtypes.",
keywords = "Breast cancer, Hormonal receptor, Human epidermal growth factor receptor 2, Skin changes, Soft tissue infiltration",
author = "Kong, {Jee Hyun} and Park, {Yeon Hee} and Kim, {Jung A.} and Kim, {Jeong Hoon} and Jina Yun and Sun, {Jong Mu} and Young-Woong Won and Soohyeon Lee and Kim, {Seung Tae} and Cho, {Eun Yoon} and Ahn, {Jin Seok} and Im, {Young Hyuck}",
year = "2011",
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Kong, JH, Park, YH, Kim, JA, Kim, JH, Yun, J, Sun, JM, Won, Y-W, Lee, S, Kim, ST, Cho, EY, Ahn, JS & Im, YH 2011, 'Patterns of skin and soft tissue metastases from breast cancer according to subtypes: Relationship between egfr overexpression and skin manifestations', Oncology, vol. 81, no. 1, pp. 55-62. https://doi.org/10.1159/000331417

Patterns of skin and soft tissue metastases from breast cancer according to subtypes : Relationship between egfr overexpression and skin manifestations. / Kong, Jee Hyun; Park, Yeon Hee; Kim, Jung A.; Kim, Jeong Hoon; Yun, Jina; Sun, Jong Mu; Won, Young-Woong; Lee, Soohyeon; Kim, Seung Tae; Cho, Eun Yoon; Ahn, Jin Seok; Im, Young Hyuck.

In: Oncology, Vol. 81, No. 1, 01.09.2011, p. 55-62.

Research output: Contribution to journalReview article

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T1 - Patterns of skin and soft tissue metastases from breast cancer according to subtypes

T2 - Relationship between egfr overexpression and skin manifestations

AU - Kong, Jee Hyun

AU - Park, Yeon Hee

AU - Kim, Jung A.

AU - Kim, Jeong Hoon

AU - Yun, Jina

AU - Sun, Jong Mu

AU - Won, Young-Woong

AU - Lee, Soohyeon

AU - Kim, Seung Tae

AU - Cho, Eun Yoon

AU - Ahn, Jin Seok

AU - Im, Young Hyuck

PY - 2011/9/1

Y1 - 2011/9/1

N2 - Objectives: We evaluated whether skin changes and soft tissue infiltration patterns reflect breast cancer subtypes based on the breast hormonal receptor (HR) and human epidermal growth factor receptor 2 (HER2) status at the time of skin metastasis. Methods: We retrospectively reviewed the patients' medical records with radiologic imaging studies. Results: The numbers of patients of each subtype were as follows: HR positive (HR+ve) 53 (42.4%), HER2 enriched 43 (34.4%), and triple negative (TN) 29 (23.2%). The presence of skin ulceration was found more commonly in the HR+ve group than in the others (57.1% for HR+ve vs. 25% for HER2 enriched vs. 15.4% for TN, p = 0.019). Erythematous infiltrations were shown predominantly in the TN group (19.0 vs. 54.2 vs. 84.6%, respectively, p < 0.000). On CT scans, soft tissue infiltration appeared to be more common in the HER2-enriched and TN groups than in the HR+ve group (24.5 vs. 41.9 vs. 48.3%, respectively, p = 0.013). Erythematous infiltrative lesions were more common in patients with epidermal growth factor receptor overexpression (p = 0.036). Conclusion: The patterns of skin involvement including surrounding soft tissue infiltration may reflect breast cancer subtype. Prospective evaluation is necessary to confirm their influential effect on breast cancer subtypes.

AB - Objectives: We evaluated whether skin changes and soft tissue infiltration patterns reflect breast cancer subtypes based on the breast hormonal receptor (HR) and human epidermal growth factor receptor 2 (HER2) status at the time of skin metastasis. Methods: We retrospectively reviewed the patients' medical records with radiologic imaging studies. Results: The numbers of patients of each subtype were as follows: HR positive (HR+ve) 53 (42.4%), HER2 enriched 43 (34.4%), and triple negative (TN) 29 (23.2%). The presence of skin ulceration was found more commonly in the HR+ve group than in the others (57.1% for HR+ve vs. 25% for HER2 enriched vs. 15.4% for TN, p = 0.019). Erythematous infiltrations were shown predominantly in the TN group (19.0 vs. 54.2 vs. 84.6%, respectively, p < 0.000). On CT scans, soft tissue infiltration appeared to be more common in the HER2-enriched and TN groups than in the HR+ve group (24.5 vs. 41.9 vs. 48.3%, respectively, p = 0.013). Erythematous infiltrative lesions were more common in patients with epidermal growth factor receptor overexpression (p = 0.036). Conclusion: The patterns of skin involvement including surrounding soft tissue infiltration may reflect breast cancer subtype. Prospective evaluation is necessary to confirm their influential effect on breast cancer subtypes.

KW - Breast cancer

KW - Hormonal receptor

KW - Human epidermal growth factor receptor 2

KW - Skin changes

KW - Soft tissue infiltration

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