Abstract
In clinical islet transplantation, intrahepatically transplanted islets are generally rejected by the host's immune response. However, they are also rapidly destroyed by other mechanisms that are unrelated to immune response. For example, isolated islets can lose the natural pancreatic microenvironment during the islet isolation process, leading to islet cell apoptosis and early graft failure. In a normal pancreas, islets are surrounded by extracellular matrix (ECM) components such as collagen, laminin, fibronectin, and so on. The interactions between islets and these ECM molecules may be very important for islet physiology in the native pancreas. By modulating intracellular signaling pathways, ECM components may play an important role in islet differentiation, proliferation, survival, and insulin secretion. However, the role of ECM molecules in regulation of pancreatic islets is still completely unknown. This article reviews current knowledge of islet-ECM interactions, evaluating the possible use of ECM molecules in improving islet transplantation outcomes. It also discusses several experimental trials of methods for enhancing the viability and functionality of islets.
| Original language | English |
|---|---|
| Pages (from-to) | 575-582 |
| Number of pages | 8 |
| Journal | Macromolecular Research |
| Volume | 22 |
| Issue number | 6 |
| DOIs | |
| State | Published - 2014 Jan 1 |
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Keywords
- diabetes
- extracellular matrix
- islet transplantation
- pancreas-like scaffold
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Pancreas-like extracellular matrix scaffold for successful pancreatic islet transplantation. / Kim, Min Jun; Lee, Dong Yun.
In: Macromolecular Research, Vol. 22, No. 6, 01.01.2014, p. 575-582.Research output: Contribution to journal › Review article
TY - JOUR
T1 - Pancreas-like extracellular matrix scaffold for successful pancreatic islet transplantation
AU - Kim, Min Jun
AU - Lee, Dong Yun
PY - 2014/1/1
Y1 - 2014/1/1
N2 - In clinical islet transplantation, intrahepatically transplanted islets are generally rejected by the host's immune response. However, they are also rapidly destroyed by other mechanisms that are unrelated to immune response. For example, isolated islets can lose the natural pancreatic microenvironment during the islet isolation process, leading to islet cell apoptosis and early graft failure. In a normal pancreas, islets are surrounded by extracellular matrix (ECM) components such as collagen, laminin, fibronectin, and so on. The interactions between islets and these ECM molecules may be very important for islet physiology in the native pancreas. By modulating intracellular signaling pathways, ECM components may play an important role in islet differentiation, proliferation, survival, and insulin secretion. However, the role of ECM molecules in regulation of pancreatic islets is still completely unknown. This article reviews current knowledge of islet-ECM interactions, evaluating the possible use of ECM molecules in improving islet transplantation outcomes. It also discusses several experimental trials of methods for enhancing the viability and functionality of islets.
AB - In clinical islet transplantation, intrahepatically transplanted islets are generally rejected by the host's immune response. However, they are also rapidly destroyed by other mechanisms that are unrelated to immune response. For example, isolated islets can lose the natural pancreatic microenvironment during the islet isolation process, leading to islet cell apoptosis and early graft failure. In a normal pancreas, islets are surrounded by extracellular matrix (ECM) components such as collagen, laminin, fibronectin, and so on. The interactions between islets and these ECM molecules may be very important for islet physiology in the native pancreas. By modulating intracellular signaling pathways, ECM components may play an important role in islet differentiation, proliferation, survival, and insulin secretion. However, the role of ECM molecules in regulation of pancreatic islets is still completely unknown. This article reviews current knowledge of islet-ECM interactions, evaluating the possible use of ECM molecules in improving islet transplantation outcomes. It also discusses several experimental trials of methods for enhancing the viability and functionality of islets.
KW - diabetes
KW - extracellular matrix
KW - islet transplantation
KW - pancreas-like scaffold
UR - http://www.scopus.com/inward/record.url?scp=84903952906&partnerID=8YFLogxK
U2 - 10.1007/s13233-014-2097-7
DO - 10.1007/s13233-014-2097-7
M3 - Review article
AN - SCOPUS:84903952906
VL - 22
SP - 575
EP - 582
JO - Macromolecular Research
JF - Macromolecular Research
SN - 1598-5032
IS - 6
ER -