Optical detection of deoxyribonucleic acid hybridization using an anchoring transition of liquid crystal alignment

Hak Rin Kim, Jae-Hoon Kim, Tae Sun Kim, Sang Wook Oh, Eui Yul Choi

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

We demonstrate an optical method for detecting specific binding events in an oligo deoxyribonucleic acid (DNA) chip using an anchoring transition of a nematic liquid crystal (NLC) as a result of DNA hybridization. A homeotropic orientation of the NLC supported by oligoDNA changes to a random planar orientation after hybridization. Such DNA hybridization and subsequent NLC reorientation are easily observable with a simple detection system via long-range orientational order and large optical anisotropy of the NLC.

Original languageEnglish
Article number143901
Pages (from-to)1-3
Number of pages3
JournalApplied Physics Letters
Volume87
Issue number14
DOIs
StatePublished - 2005 Oct 3

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deoxyribonucleic acid
liquid crystals
alignment
retraining
chips
optics
anisotropy

Cite this

Kim, Hak Rin ; Kim, Jae-Hoon ; Kim, Tae Sun ; Oh, Sang Wook ; Choi, Eui Yul. / Optical detection of deoxyribonucleic acid hybridization using an anchoring transition of liquid crystal alignment. In: Applied Physics Letters. 2005 ; Vol. 87, No. 14. pp. 1-3.
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Optical detection of deoxyribonucleic acid hybridization using an anchoring transition of liquid crystal alignment. / Kim, Hak Rin; Kim, Jae-Hoon; Kim, Tae Sun; Oh, Sang Wook; Choi, Eui Yul.

In: Applied Physics Letters, Vol. 87, No. 14, 143901, 03.10.2005, p. 1-3.

Research output: Contribution to journalArticle

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AU - Choi, Eui Yul

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