Novel preparative method for porous hydrogels using overrun process

Hyun Goo Kang, Sang Bong Lee, Young Moo Lee

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Porous poly(vinyl alcohol) (PVA) hydrogels were prepared using the overrun process which is usually used in manufacturing ice cream. The pores in the hydrogel formed exhibit dual-pore structure due to the injection of air bubbles and ice recrystallization. Morphological investigation revealed that overrun-processed hydrogels had closed pore structures and that their pore size and size distribution had been influenced by the impeller rate and concentration of polymer solution. The closed-pore structure was reformed into interconnected open-pore structure at lower concentrations of the solution. The freeze-thawing process, which takes place in PVA cross-linking, has no effect on the bubble structure, but removes the small pores formed during ice recrystallization. Besides the swelling ratio of overrun-processed PVA hydrogels is increased tenfold in comparison with non-porous hydrogels. Overrun-processed hydrogels showed more rapid swelling kinetics than freeze-dried and film-like hydrogels due to their larger surface area. In the future, the overrun process can be applied to prepare porous scaffolds containing proteins, such as growth factors and other cytokines, without denaturation, because it operates at a low temperature.

Original languageEnglish
Pages (from-to)537-543
Number of pages7
JournalPolymer International
Volume54
Issue number3
DOIs
StatePublished - 2005 Mar 1

Fingerprint

Hydrogels
Pore structure
Ice
Swelling
Denaturation
Thawing
Hydrogel
Polymer solutions
Scaffolds
Pore size
Scaffolds (biology)
Intercellular Signaling Peptides and Proteins
Alcohols
Cytokines
Kinetics
Proteins
Air

Keywords

  • Overrun process
  • PVA hydrogel
  • Pore structure
  • Porous hydrogel

Cite this

Kang, Hyun Goo ; Lee, Sang Bong ; Lee, Young Moo. / Novel preparative method for porous hydrogels using overrun process. In: Polymer International. 2005 ; Vol. 54, No. 3. pp. 537-543.
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Novel preparative method for porous hydrogels using overrun process. / Kang, Hyun Goo; Lee, Sang Bong; Lee, Young Moo.

In: Polymer International, Vol. 54, No. 3, 01.03.2005, p. 537-543.

Research output: Contribution to journalArticle

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