Novel genetic variations associated with salt sensitivity in the Korean population

Moo Yong Rhee, Soo Jin Yang, Sang Woo Oh, Yongsoon Park, Cho Il Kim, Hye Kyung Park, Sung Woo Park, Cheol Young Park

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Salt sensitivity is a risk factor for cardiovascular morbidity and mortality. To date, only a few genetic variations have been identified as being associated with salt sensitivity. This study aimed to estimate the prevalence of salt sensitivity in the Korean population and to identify genetic variants affecting its development. A total of 101 Korean participants consumed a low-salt diet for 7 days followed by a high-salt diet for 7 additional days. Salt sensitivity was determined by noting any significant elevation in the 24-h mean arterial blood pressure. To determine genetic variants affecting salt sensitivity, 36 single-nucleotide polymorphisms (SNPs) that were previously reported to be associated with hypertension were tested for any associations with salt sensitivity. Of the 101 subjects, 28 (27.7%) were determined to have salt sensitivity. Out of the 36 SNPs tested, four were significantly associated with salt sensitivity after adjusting for confounding factors: rs2681472 in ATPase, Ca transporting, plasma membrane 1 (ATP2B1), rs7961152 in branched chain aminotransferase 1 (BCAT1), rs16998073 in fibroblast growth factor 5 (FGF5) and rs2398162 in LOC100132798. For rs3754777 in serine threonine kinase 39 (STK39) and rs1937506, associations with salt sensitivity were observed before adjusting for confounding factors. Haplotype analysis revealed that the A-C haplotype of rs3754777-rs6749447 in STK39 was more frequent in the salt-sensitive group compared with the salt-resistant group, and was associated with salt sensitivity. This study estimates the prevalence of salt sensitivity in the Korean population and demonstrates a novel association between salt sensitivity and the ATP2B1, BCAT1, FGF5, LOC100132798 and STK39 genetic variations.

Original languageEnglish
Pages (from-to)606-611
Number of pages6
JournalHypertension Research
Volume34
Issue number5
DOIs
StatePublished - 2011 May 1

Fingerprint

Salts
Population
Fibroblast Growth Factor 5
Protein-Serine-Threonine Kinases
Haplotypes
Single Nucleotide Polymorphism
Arterial Pressure
Sodium-Restricted Diet
Adenosine Triphosphatases
Cross-Sectional Studies
Cell Membrane
Diet
Hypertension
Morbidity
Mortality

Keywords

  • blood pressure
  • salt sensitivity
  • single-nucleotide polymorphism

Cite this

Rhee, M. Y., Yang, S. J., Oh, S. W., Park, Y., Kim, C. I., Park, H. K., ... Park, C. Y. (2011). Novel genetic variations associated with salt sensitivity in the Korean population. Hypertension Research, 34(5), 606-611. https://doi.org/10.1038/hr.2010.278
Rhee, Moo Yong ; Yang, Soo Jin ; Oh, Sang Woo ; Park, Yongsoon ; Kim, Cho Il ; Park, Hye Kyung ; Park, Sung Woo ; Park, Cheol Young. / Novel genetic variations associated with salt sensitivity in the Korean population. In: Hypertension Research. 2011 ; Vol. 34, No. 5. pp. 606-611.
@article{0079f036e6aa45749d84f19c893a0294,
title = "Novel genetic variations associated with salt sensitivity in the Korean population",
abstract = "Salt sensitivity is a risk factor for cardiovascular morbidity and mortality. To date, only a few genetic variations have been identified as being associated with salt sensitivity. This study aimed to estimate the prevalence of salt sensitivity in the Korean population and to identify genetic variants affecting its development. A total of 101 Korean participants consumed a low-salt diet for 7 days followed by a high-salt diet for 7 additional days. Salt sensitivity was determined by noting any significant elevation in the 24-h mean arterial blood pressure. To determine genetic variants affecting salt sensitivity, 36 single-nucleotide polymorphisms (SNPs) that were previously reported to be associated with hypertension were tested for any associations with salt sensitivity. Of the 101 subjects, 28 (27.7{\%}) were determined to have salt sensitivity. Out of the 36 SNPs tested, four were significantly associated with salt sensitivity after adjusting for confounding factors: rs2681472 in ATPase, Ca transporting, plasma membrane 1 (ATP2B1), rs7961152 in branched chain aminotransferase 1 (BCAT1), rs16998073 in fibroblast growth factor 5 (FGF5) and rs2398162 in LOC100132798. For rs3754777 in serine threonine kinase 39 (STK39) and rs1937506, associations with salt sensitivity were observed before adjusting for confounding factors. Haplotype analysis revealed that the A-C haplotype of rs3754777-rs6749447 in STK39 was more frequent in the salt-sensitive group compared with the salt-resistant group, and was associated with salt sensitivity. This study estimates the prevalence of salt sensitivity in the Korean population and demonstrates a novel association between salt sensitivity and the ATP2B1, BCAT1, FGF5, LOC100132798 and STK39 genetic variations.",
keywords = "blood pressure, salt sensitivity, single-nucleotide polymorphism",
author = "Rhee, {Moo Yong} and Yang, {Soo Jin} and Oh, {Sang Woo} and Yongsoon Park and Kim, {Cho Il} and Park, {Hye Kyung} and Park, {Sung Woo} and Park, {Cheol Young}",
year = "2011",
month = "5",
day = "1",
doi = "10.1038/hr.2010.278",
language = "English",
volume = "34",
pages = "606--611",
journal = "Hypertension Research",
issn = "0916-9636",
number = "5",

}

Rhee, MY, Yang, SJ, Oh, SW, Park, Y, Kim, CI, Park, HK, Park, SW & Park, CY 2011, 'Novel genetic variations associated with salt sensitivity in the Korean population', Hypertension Research, vol. 34, no. 5, pp. 606-611. https://doi.org/10.1038/hr.2010.278

Novel genetic variations associated with salt sensitivity in the Korean population. / Rhee, Moo Yong; Yang, Soo Jin; Oh, Sang Woo; Park, Yongsoon; Kim, Cho Il; Park, Hye Kyung; Park, Sung Woo; Park, Cheol Young.

In: Hypertension Research, Vol. 34, No. 5, 01.05.2011, p. 606-611.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Novel genetic variations associated with salt sensitivity in the Korean population

AU - Rhee, Moo Yong

AU - Yang, Soo Jin

AU - Oh, Sang Woo

AU - Park, Yongsoon

AU - Kim, Cho Il

AU - Park, Hye Kyung

AU - Park, Sung Woo

AU - Park, Cheol Young

PY - 2011/5/1

Y1 - 2011/5/1

N2 - Salt sensitivity is a risk factor for cardiovascular morbidity and mortality. To date, only a few genetic variations have been identified as being associated with salt sensitivity. This study aimed to estimate the prevalence of salt sensitivity in the Korean population and to identify genetic variants affecting its development. A total of 101 Korean participants consumed a low-salt diet for 7 days followed by a high-salt diet for 7 additional days. Salt sensitivity was determined by noting any significant elevation in the 24-h mean arterial blood pressure. To determine genetic variants affecting salt sensitivity, 36 single-nucleotide polymorphisms (SNPs) that were previously reported to be associated with hypertension were tested for any associations with salt sensitivity. Of the 101 subjects, 28 (27.7%) were determined to have salt sensitivity. Out of the 36 SNPs tested, four were significantly associated with salt sensitivity after adjusting for confounding factors: rs2681472 in ATPase, Ca transporting, plasma membrane 1 (ATP2B1), rs7961152 in branched chain aminotransferase 1 (BCAT1), rs16998073 in fibroblast growth factor 5 (FGF5) and rs2398162 in LOC100132798. For rs3754777 in serine threonine kinase 39 (STK39) and rs1937506, associations with salt sensitivity were observed before adjusting for confounding factors. Haplotype analysis revealed that the A-C haplotype of rs3754777-rs6749447 in STK39 was more frequent in the salt-sensitive group compared with the salt-resistant group, and was associated with salt sensitivity. This study estimates the prevalence of salt sensitivity in the Korean population and demonstrates a novel association between salt sensitivity and the ATP2B1, BCAT1, FGF5, LOC100132798 and STK39 genetic variations.

AB - Salt sensitivity is a risk factor for cardiovascular morbidity and mortality. To date, only a few genetic variations have been identified as being associated with salt sensitivity. This study aimed to estimate the prevalence of salt sensitivity in the Korean population and to identify genetic variants affecting its development. A total of 101 Korean participants consumed a low-salt diet for 7 days followed by a high-salt diet for 7 additional days. Salt sensitivity was determined by noting any significant elevation in the 24-h mean arterial blood pressure. To determine genetic variants affecting salt sensitivity, 36 single-nucleotide polymorphisms (SNPs) that were previously reported to be associated with hypertension were tested for any associations with salt sensitivity. Of the 101 subjects, 28 (27.7%) were determined to have salt sensitivity. Out of the 36 SNPs tested, four were significantly associated with salt sensitivity after adjusting for confounding factors: rs2681472 in ATPase, Ca transporting, plasma membrane 1 (ATP2B1), rs7961152 in branched chain aminotransferase 1 (BCAT1), rs16998073 in fibroblast growth factor 5 (FGF5) and rs2398162 in LOC100132798. For rs3754777 in serine threonine kinase 39 (STK39) and rs1937506, associations with salt sensitivity were observed before adjusting for confounding factors. Haplotype analysis revealed that the A-C haplotype of rs3754777-rs6749447 in STK39 was more frequent in the salt-sensitive group compared with the salt-resistant group, and was associated with salt sensitivity. This study estimates the prevalence of salt sensitivity in the Korean population and demonstrates a novel association between salt sensitivity and the ATP2B1, BCAT1, FGF5, LOC100132798 and STK39 genetic variations.

KW - blood pressure

KW - salt sensitivity

KW - single-nucleotide polymorphism

UR - http://www.scopus.com/inward/record.url?scp=79955614021&partnerID=8YFLogxK

U2 - 10.1038/hr.2010.278

DO - 10.1038/hr.2010.278

M3 - Article

C2 - 21228780

AN - SCOPUS:79955614021

VL - 34

SP - 606

EP - 611

JO - Hypertension Research

JF - Hypertension Research

SN - 0916-9636

IS - 5

ER -