Nondiseased liver stiffness measured by shearwave elastography a pilot study

Seung Woo Cha, Woo Kyoung Jeong, Yong Soo Kim, Min Yeong Kim, Jinoo Kim, Yeon Kim, Jeong Ah Ryu, Tae Yeob Kim, Joo Hyun Sohn, Young Hwan Kim

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

Objectives-The purpose of this study was to investigate the value of liver stiffness in patients without liver disease using shear wave elastography and to determine the liver stiffness threshold value for identifying patients with chronic liver diseases. Methods-Atotal of 150 patientswhounderwent liver sonography coupled with shear wave elastography were enrolled. On the basis of clinical and pathologic criteria, they were assigned to 1 of 2 groups: nondiseased liver (n = 97) and noncirrhotic chronic liver disease (n = 53). Liver stiffness was measured in the right liver, and the median value of 10 measurements was calculated. Both mean and median values in the nondiseased liver group were compared with those in the noncirrhotic chronic liver disease group. To validate this comparison, liver stiffness of the patients who underwent liver biopsy revealing either no fibrosis (fibrosis score F0; n = 5) or substantial fibrosis (F2; n = 14) was also investigated and compared. Todetermine the optimal threshold value for determining chronic liver disease, a receiver operating characteristic curve analysis was performed. Results-The mean liver stiffness value in the nondiseased liver group was 5.4 kPa. In the noncirrhotic chronic liver disease group, the mean value was 8.1 kPa. Differences between the nondiseased liver and both noncirrhotic chronic liver disease groups were statistically significant (P < .001). The optimal liver stiffness threshold value for discriminating nondiseased liver from noncirrhotic chronic liver disease was 6.9 kPa. The sensitivity using this threshold was 94%. In the biopsy-proven patients, the mean liver stiffness values were 6.0 kPa in the F0 group and 9.9 kPa in the F2 group. Conclusions-The range of liver stiffness in patients with nondiseased liver and the optimal threshold value for discriminating these patients from those with chronic liver disease were identified.

Original languageEnglish
Pages (from-to)53-60
Number of pages8
JournalJournal of Ultrasound in Medicine
Volume33
Issue number1
DOIs
StatePublished - 2014 Jan 1

Keywords

  • Chronic liver disease
  • Gastrointestinal ultrasound
  • Liver stiffness
  • Nondiseased liver
  • Shear wave elastography

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