NHC-catalyzed oxidative cyclization reaction for the synthesis of 3-substituted phthalides

So Won Youn, Hyoung Sub Song, Jong Hyub Park

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

An efficient NHC-catalyzed domino oxidation/oxa-Michael addition reaction of 2-alkenylbenzaldehydes has been developed to afford 3-substituted phthalides bearing a C3-stereogenic center with a broad substrate scope and wide functional group tolerance. The preliminary results of the asymmetric process have been provided as well.

Original languageEnglish
Pages (from-to)2388-2393
Number of pages6
JournalOrganic and Biomolecular Chemistry
Volume12
Issue number15
DOIs
StatePublished - 2014 Apr 21

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Bearings (structural)
Addition reactions
Cyclization
Functional groups
Oxidation
oxidation
Substrates
synthesis
phthalide

Cite this

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NHC-catalyzed oxidative cyclization reaction for the synthesis of 3-substituted phthalides. / Youn, So Won; Song, Hyoung Sub; Park, Jong Hyub.

In: Organic and Biomolecular Chemistry, Vol. 12, No. 15, 21.04.2014, p. 2388-2393.

Research output: Contribution to journalArticle

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