miR-215 overexpression distinguishes ampullary carcinomas from pancreatic carcinoma

Dongho Choi, Sang Jae Park, Hark Kyun Kim

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Distinguishing ampullary carcinoma from pancreatic carcinoma is important because of their different prognoses. microRNAs are differentially expressed according to the tissue of origin. However, there is rare research on the differential diagnosis between the two types of cancers by microRNA in periampullary cancers. The present study was undertaken to compare microRNA profiles between ampullary and pancreatic carcinomas using microarrays. miR-215 was most significantly overexpressed in ampullary carcinomas; whereas the expressions of miR-134 and miR-214 were significantly lower in ampullary carcinomas than in pancreatic carcinomas. When these discriminatory microRNAs were applied to liver metastases, they were correctly predicted for the tissue of origin. Although this study is limited by small sample size, striking difference in microRNA expression and concordant expression of discriminating microRNAs in primary tumors and metastases suggest that these novel discriminatory microRNAs warrant future validation.

Original languageEnglish
Pages (from-to)325-329
Number of pages5
JournalHepatobiliary and Pancreatic Diseases International
Volume14
Issue number3
DOIs
StatePublished - 2015 Jan 1

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MicroRNAs
Carcinoma
Neoplasm Metastasis
Neoplasms
Pancreatic Carcinoma
Sample Size
Differential Diagnosis
Liver
Research

Keywords

  • Ampulla of Vater
  • Gene expression
  • Pancreatic cancer

Cite this

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abstract = "Distinguishing ampullary carcinoma from pancreatic carcinoma is important because of their different prognoses. microRNAs are differentially expressed according to the tissue of origin. However, there is rare research on the differential diagnosis between the two types of cancers by microRNA in periampullary cancers. The present study was undertaken to compare microRNA profiles between ampullary and pancreatic carcinomas using microarrays. miR-215 was most significantly overexpressed in ampullary carcinomas; whereas the expressions of miR-134 and miR-214 were significantly lower in ampullary carcinomas than in pancreatic carcinomas. When these discriminatory microRNAs were applied to liver metastases, they were correctly predicted for the tissue of origin. Although this study is limited by small sample size, striking difference in microRNA expression and concordant expression of discriminating microRNAs in primary tumors and metastases suggest that these novel discriminatory microRNAs warrant future validation.",
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miR-215 overexpression distinguishes ampullary carcinomas from pancreatic carcinoma. / Choi, Dongho; Park, Sang Jae; Kim, Hark Kyun.

In: Hepatobiliary and Pancreatic Diseases International, Vol. 14, No. 3, 01.01.2015, p. 325-329.

Research output: Contribution to journalArticle

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AU - Kim, Hark Kyun

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AB - Distinguishing ampullary carcinoma from pancreatic carcinoma is important because of their different prognoses. microRNAs are differentially expressed according to the tissue of origin. However, there is rare research on the differential diagnosis between the two types of cancers by microRNA in periampullary cancers. The present study was undertaken to compare microRNA profiles between ampullary and pancreatic carcinomas using microarrays. miR-215 was most significantly overexpressed in ampullary carcinomas; whereas the expressions of miR-134 and miR-214 were significantly lower in ampullary carcinomas than in pancreatic carcinomas. When these discriminatory microRNAs were applied to liver metastases, they were correctly predicted for the tissue of origin. Although this study is limited by small sample size, striking difference in microRNA expression and concordant expression of discriminating microRNAs in primary tumors and metastases suggest that these novel discriminatory microRNAs warrant future validation.

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