Methods to control batch integrity in SMB chromatography for linear systems

Sungyong Mun, Nien Hwa Linda Wang

Research output: Contribution to conferencePaper

Abstract

For a pharmaceutical like insulin, the product should be clearly linked to its source. Therefore, it is important to track each batch throughout the production process. Tracking each batch in a simulated moving bed (SMB) process is more challenging than in conventional batch chromatography. Solutes coming from a certain feed batch in SMB can be mixed with solutes coming from adjacent feed batches as a result of periodic port movement, internal recycle, and dispersion due to mass transfer. The degree of mixing or the size of the overlap region in the product stream largely depends on solute residence time. Using partial feeding, or applying pinched wave operating conditions can effectively reduce residence time and therefore decrease the overlap region. To eliminate the overlap region completely, an eluent gap can be applied between adjacent feed batch injections. The strategies for reducing residence time can minimize the eluent gap, thereby reducing eluent consumption and increasing productivity. One can further reduce the amount of eluent by operating as a three-zone SMB during the gap period and a four-zone SMB during the feed injection period.

Original languageEnglish
Pages5013-5029
Number of pages17
StatePublished - 2004 Dec 1
Event2004 AIChE Annual Meeting - Austin, TX, United States
Duration: 2004 Nov 72004 Nov 12

Other

Other2004 AIChE Annual Meeting
CountryUnited States
CityAustin, TX
Period04/11/704/11/12

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Insulin
Chromatography
Drug products
Linear systems
Mass transfer
Productivity

Cite this

Mun, S., & Wang, N. H. L. (2004). Methods to control batch integrity in SMB chromatography for linear systems. 5013-5029. Paper presented at 2004 AIChE Annual Meeting, Austin, TX, United States.
Mun, Sungyong ; Wang, Nien Hwa Linda. / Methods to control batch integrity in SMB chromatography for linear systems. Paper presented at 2004 AIChE Annual Meeting, Austin, TX, United States.17 p.
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Mun, S & Wang, NHL 2004, 'Methods to control batch integrity in SMB chromatography for linear systems' Paper presented at 2004 AIChE Annual Meeting, Austin, TX, United States, 04/11/7 - 04/11/12, pp. 5013-5029.

Methods to control batch integrity in SMB chromatography for linear systems. / Mun, Sungyong; Wang, Nien Hwa Linda.

2004. 5013-5029 Paper presented at 2004 AIChE Annual Meeting, Austin, TX, United States.

Research output: Contribution to conferencePaper

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AB - For a pharmaceutical like insulin, the product should be clearly linked to its source. Therefore, it is important to track each batch throughout the production process. Tracking each batch in a simulated moving bed (SMB) process is more challenging than in conventional batch chromatography. Solutes coming from a certain feed batch in SMB can be mixed with solutes coming from adjacent feed batches as a result of periodic port movement, internal recycle, and dispersion due to mass transfer. The degree of mixing or the size of the overlap region in the product stream largely depends on solute residence time. Using partial feeding, or applying pinched wave operating conditions can effectively reduce residence time and therefore decrease the overlap region. To eliminate the overlap region completely, an eluent gap can be applied between adjacent feed batch injections. The strategies for reducing residence time can minimize the eluent gap, thereby reducing eluent consumption and increasing productivity. One can further reduce the amount of eluent by operating as a three-zone SMB during the gap period and a four-zone SMB during the feed injection period.

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Mun S, Wang NHL. Methods to control batch integrity in SMB chromatography for linear systems. 2004. Paper presented at 2004 AIChE Annual Meeting, Austin, TX, United States.