Metal-Catalyzed Synthesis of Substituted Indoles

So Won Youn, Tae Yun Ko

Research output: Contribution to journalReview article

15 Citations (Scopus)

Abstract

Indoles are important structural motifs that are commonly found in a diverse array of natural products, pharmaceuticals, and other functional molecules. Consequently, the development of new, more efficient synthetic methods for the construction of substituted indoles continues to be of great importance and considerable interest. Over the past few decades, metal-catalyzed C−C/C−N bond-forming reactions have emerged as a powerful synthetic strategy for heterocyclic synthesis. In this review, we have provided a brief overview of recent advances in the metal-catalyzed synthesis of substituted indoles through the construction of the pyrrole nucleus of indoles, involving the formation of multiple C−C/C−N bonds.

Original languageEnglish
Pages (from-to)1467-1487
Number of pages21
JournalAsian Journal of Organic Chemistry
Volume7
Issue number8
DOIs
StatePublished - 2018 Aug 1

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Indoles
Metals
Pyrroles
Biological Products
Molecules
Pharmaceutical Preparations

Keywords

  • C−C bond formation
  • C−N bond formation
  • heterocycles
  • indoles
  • transition metals

Cite this

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Metal-Catalyzed Synthesis of Substituted Indoles. / Youn, So Won; Ko, Tae Yun.

In: Asian Journal of Organic Chemistry, Vol. 7, No. 8, 01.08.2018, p. 1467-1487.

Research output: Contribution to journalReview article

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T1 - Metal-Catalyzed Synthesis of Substituted Indoles

AU - Youn, So Won

AU - Ko, Tae Yun

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AB - Indoles are important structural motifs that are commonly found in a diverse array of natural products, pharmaceuticals, and other functional molecules. Consequently, the development of new, more efficient synthetic methods for the construction of substituted indoles continues to be of great importance and considerable interest. Over the past few decades, metal-catalyzed C−C/C−N bond-forming reactions have emerged as a powerful synthetic strategy for heterocyclic synthesis. In this review, we have provided a brief overview of recent advances in the metal-catalyzed synthesis of substituted indoles through the construction of the pyrrole nucleus of indoles, involving the formation of multiple C−C/C−N bonds.

KW - C−C bond formation

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