Maternal outcomes and follow-up of preterm and term neonates born to mothers with systemic lupus erythematosus

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Abstract

Objective: There is little follow-up data in preterm infants from mothers with systemic lupus erythematosus (SLE). The aim of this study was to determine maternal outcomes and compare neonatal outcomes in preterm and term infants born to mothers with SLE. Methods: This study is a prospective study in a tertiary medical care center and clinical research center for rheumatoid arthritis. Demographic data, clinical features, laboratory findings, treatment and complications in 77 pregnant SLE patients were prospectively evaluated from 2007 to 2013. Results: Ninety-two infants (44 males and 48 females including four sets of twins) from 77 mothers with SLE were enrolled. Multivariate logistic analysis indicated that flares were significantly associated with antiphospholipid antibodies of lupus anticoagulant during pregnancy (p = 0.009) and preterm birth (p = 0.017). Compared with term infants, preterm infants had significantly higher antinuclear antibodies (ANA) positivity (p = 0.001) at 12 months of age in multivariate logistic analysis. Conclusion: Preterm birth is associated with maternal flares and persistent ANA positivity at 12 months of life in infants born to mothers with SLE.

Original languageEnglish
Pages (from-to)7-13
Number of pages7
JournalJournal of Maternal-Fetal and Neonatal Medicine
Volume31
Issue number1
DOIs
StatePublished - 2018 Jan 2

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Systemic Lupus Erythematosus
Mothers
Newborn Infant
Premature Infants
Antinuclear Antibodies
Premature Birth
Multivariate Analysis
Lupus Coagulation Inhibitor
Antiphospholipid Antibodies
Tertiary Care Centers
Rheumatoid Arthritis
Demography
Prospective Studies
Pregnancy
Research

Keywords

  • Antinuclear antibody
  • follow-up
  • lupus flare
  • lupus pregnancy
  • premature infants

Cite this

@article{2ba451e20e284b5bb707f8c884339263,
title = "Maternal outcomes and follow-up of preterm and term neonates born to mothers with systemic lupus erythematosus",
abstract = "Objective: There is little follow-up data in preterm infants from mothers with systemic lupus erythematosus (SLE). The aim of this study was to determine maternal outcomes and compare neonatal outcomes in preterm and term infants born to mothers with SLE. Methods: This study is a prospective study in a tertiary medical care center and clinical research center for rheumatoid arthritis. Demographic data, clinical features, laboratory findings, treatment and complications in 77 pregnant SLE patients were prospectively evaluated from 2007 to 2013. Results: Ninety-two infants (44 males and 48 females including four sets of twins) from 77 mothers with SLE were enrolled. Multivariate logistic analysis indicated that flares were significantly associated with antiphospholipid antibodies of lupus anticoagulant during pregnancy (p = 0.009) and preterm birth (p = 0.017). Compared with term infants, preterm infants had significantly higher antinuclear antibodies (ANA) positivity (p = 0.001) at 12 months of age in multivariate logistic analysis. Conclusion: Preterm birth is associated with maternal flares and persistent ANA positivity at 12 months of life in infants born to mothers with SLE.",
keywords = "Antinuclear antibody, follow-up, lupus flare, lupus pregnancy, premature infants",
author = "Hwang, {Jae Kyoon} and Park, {Hyun Kyung} and Yoon-Kyoung Sung and Hoh, {Jeong Kyu} and Lee, {Hyun Ju}",
year = "2018",
month = "1",
day = "2",
doi = "10.1080/14767058.2016.1205027",
language = "English",
volume = "31",
pages = "7--13",
journal = "Journal of Maternal-Fetal and Neonatal Medicine",
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T1 - Maternal outcomes and follow-up of preterm and term neonates born to mothers with systemic lupus erythematosus

AU - Hwang, Jae Kyoon

AU - Park, Hyun Kyung

AU - Sung, Yoon-Kyoung

AU - Hoh, Jeong Kyu

AU - Lee, Hyun Ju

PY - 2018/1/2

Y1 - 2018/1/2

N2 - Objective: There is little follow-up data in preterm infants from mothers with systemic lupus erythematosus (SLE). The aim of this study was to determine maternal outcomes and compare neonatal outcomes in preterm and term infants born to mothers with SLE. Methods: This study is a prospective study in a tertiary medical care center and clinical research center for rheumatoid arthritis. Demographic data, clinical features, laboratory findings, treatment and complications in 77 pregnant SLE patients were prospectively evaluated from 2007 to 2013. Results: Ninety-two infants (44 males and 48 females including four sets of twins) from 77 mothers with SLE were enrolled. Multivariate logistic analysis indicated that flares were significantly associated with antiphospholipid antibodies of lupus anticoagulant during pregnancy (p = 0.009) and preterm birth (p = 0.017). Compared with term infants, preterm infants had significantly higher antinuclear antibodies (ANA) positivity (p = 0.001) at 12 months of age in multivariate logistic analysis. Conclusion: Preterm birth is associated with maternal flares and persistent ANA positivity at 12 months of life in infants born to mothers with SLE.

AB - Objective: There is little follow-up data in preterm infants from mothers with systemic lupus erythematosus (SLE). The aim of this study was to determine maternal outcomes and compare neonatal outcomes in preterm and term infants born to mothers with SLE. Methods: This study is a prospective study in a tertiary medical care center and clinical research center for rheumatoid arthritis. Demographic data, clinical features, laboratory findings, treatment and complications in 77 pregnant SLE patients were prospectively evaluated from 2007 to 2013. Results: Ninety-two infants (44 males and 48 females including four sets of twins) from 77 mothers with SLE were enrolled. Multivariate logistic analysis indicated that flares were significantly associated with antiphospholipid antibodies of lupus anticoagulant during pregnancy (p = 0.009) and preterm birth (p = 0.017). Compared with term infants, preterm infants had significantly higher antinuclear antibodies (ANA) positivity (p = 0.001) at 12 months of age in multivariate logistic analysis. Conclusion: Preterm birth is associated with maternal flares and persistent ANA positivity at 12 months of life in infants born to mothers with SLE.

KW - Antinuclear antibody

KW - follow-up

KW - lupus flare

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KW - premature infants

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