Magnetic resonance image-based tomotherapy planning for prostate cancer

Sang Hoon Jung, Jinsung Kim, Yoonsun Chung, Bilgin Keserci, Hongryull Pyo, Hee Chul Park, Won Park

Research output: Contribution to journalArticle


Purpose: To evaluate and compare the feasibilities of magnetic resonance (MR) image-based planning using synthetic computed tomography (sCT) versus CT (pCT)-based planning in helical tomother-apy for prostate cancer. Materials and Methods: A retrospective evaluation was performed in 16 patients with prostate cancer who had been treated with helical tomotherapy. MR images were acquired using a dedicated therapy sequence; sCT images were generated using magnetic resonance for calculating attenuation (MRCAT). The three-dimensional dose distribution according to sCT was recalculated using a previously optimized plan and was compared with the doses calculated using pCT. Results: The mean planning target volume doses calculated by sCT and pCT differed by 0.65% ± 1.11% (p = 0.03). Three-dimensional gamma analysis at a 2%/2 mm dose difference/distance to agreement yielded a pass rate of 0.976 (range, 0.658 to 0.986). Conclusion: The dose distribution results obtained using tomotherapy from MR-only simulations were in good agreement with the dose distribution results from simulation CT, with mean dose differences of less than 1% for target volume and normal organs in patients with prostate cancer.

Original languageEnglish
Pages (from-to)52-59
Number of pages8
JournalRadiation Oncology Journal
Issue number1
StatePublished - 2020 Mar


  • Helical tomotherapy
  • Magnetic resonance imaging
  • Prostatic neoplasms

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