Longitudinal changes in resting-state brain activity in a capsular infarct model

Donghyeon Kim, Ra Gyung Kim, Hyung Sun Kim, Jin Myung Kim, Sung Chan Jun, Boreom Lee, Hang Joon Jo, Pedro R. Neto, Min Cheol Lee, Hyoung Ihl Kim

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Strokes attributable to subcortical infarcts have been increasing recently in elderly patients. To gain insight how this lesion influences the motor outcome and responds to rehabilitative training, we used circumscribed photothrombotic capsular infarct models on 36 Sprague-Dawley rats (24 experimental and 12 sham-operated). We used 2-deoxy-2-[ 18 F]-fluoro-D-glucose-micro positron emission tomography (FDG-microPET) to assess longitudinal changes in resting-state brain activity (rs-BA) and daily single-pellet reaching task (SPRT) trainings to evaluate motor recovery. Longitudinal FDG-microPET results showed that capsular infarct resulted in a persistent decrease in rs-BA in bilateral sensory and auditory cortices, and ipsilesional motor cortex, thalamus, and inferior colliculus (P<0.0025, false discovery rate (FDR) q<0.05). The decreased rs-BA is compatible with diaschisis and contributes to manifest the malfunctions of lesion-specific functional connectivity. In contrast, capsular infarct resulted in increase of rs-BA in the ipsilesional internal capsule, and contralesional red nucleus and ventral hippocampus in recovery group (P<0.0025, FDR q<0.05), implying that remaining subcortical structures have an important role in conducting the recovery process in capsular infarct. The SPRT training facilitated motor recovery only in rats with an incomplete destruction of the posterior limb of the internal capsule (PLIC) (Pearson's correlation, P<0.05). Alternative therapeutic interventions are required to enhance the potential for recovery in capsular infarct with complete destruction of PLIC.

Original languageEnglish
Pages (from-to)11-19
Number of pages9
JournalJournal of Cerebral Blood Flow and Metabolism
Volume35
Issue number1
DOIs
StatePublished - 2015 Jan 10

Keywords

  • cerebrovascular disease
  • lacunar infarcts
  • positron emission tomography
  • rehabilitation
  • white-matter disease

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    Kim, D., Kim, R. G., Kim, H. S., Kim, J. M., Jun, S. C., Lee, B., Jo, H. J., Neto, P. R., Lee, M. C., & Kim, H. I. (2015). Longitudinal changes in resting-state brain activity in a capsular infarct model. Journal of Cerebral Blood Flow and Metabolism, 35(1), 11-19. https://doi.org/10.1038/jcbfm.2014.178