Label-free protein nano-biosensor using top-down fabrication

Chil Seong Ah, Ansoon Kim, Han Young Yu, Chang Geun Ahn, Jong Heon Yang, In Bok Baek, Chan Woo Park, Myung Sim Jun, Seong Jae Lee

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

A nanosensor of n-type Si field-effect transistor (FET) via top-down method was employed to monitor PSA with great selectivity and high sensitivity up to 10 pg/mL. When a biomaterial, negatively charged PSA, is introduced into a fluidic channel, the conductivity of FET is lowered than that in pure buffer solution from the n-type nature of nanochannel as a nanobiosensor. The Si FET nanobiosensor offers a label-free and real-time monitoring, which explains the origin of electrical property resulting from the specific binding between antibody and antigen.

Original languageEnglish
Title of host publication2007 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2007, Technical Proceedings
Pages493-495
Number of pages3
Publication statusPublished - 2007 Aug 23
Event2007 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2007 - Santa Clara, CA, United States
Duration: 2007 May 202007 May 24

Publication series

Name2007 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2007, Technical Proceedings
Volume2

Other

Other2007 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2007
CountryUnited States
CitySanta Clara, CA
Period07/05/2007/05/24

    Fingerprint

Keywords

  • Electrical detection
  • Nanosensor
  • PSA
  • Protein
  • Si FET
  • Top-down

Cite this

Ah, C. S., Kim, A., Yu, H. Y., Ahn, C. G., Yang, J. H., Baek, I. B., ... Lee, S. J. (2007). Label-free protein nano-biosensor using top-down fabrication. In 2007 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2007, Technical Proceedings (pp. 493-495). (2007 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2007, Technical Proceedings; Vol. 2).