Korean OBEsity Surgical Treatment Study (KOBESS): Protocol of a prospective multicentre cohort study on obese patients undergoing laparoscopic sleeve gastrectomy and Roux-en-Y gastric bypass

Young Suk Park, Do Joong Park, Joo Ho Lee, Hyuk Joon Lee, Tae Kyung Ha, Yong Jin Kim, Seung Wan Ryu, Sang Moon Han, Moon Won Yoo, Sungsoo Park, Sang Uk Han, Yoonseok Heo

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Introduction Bariatric surgery effectively induces long-term weight loss in Western populations. However, its effectiveness in Asians remains to be confirmed objectively. The Korean Society for Metabolic and Bariatric Surgery proposes the first prospective cohort study on Koreans undergoing bariatric surgery. Methods and analysis The Korean OBEsity Surgical treatment Study (KOBESS) is a prospective, multicentre, single-arm, observational, cohort study on morbidly obese patients who undergo primary sleeve gastrectomy or Roux-en-Y gastric bypass in Korea. In total, 100 consecutive obese Asian patients who will undergo bariatric surgery will be recruited in 2016-2017; follow-up will be for 1 year. Primary outcomes are change in body weight and waist circumference at 1 year. All patients will undergo anthropometry, laboratory tests, bioelectrical impedance analysis, gastrofibroscopy, polysomnography and fat-measuring CT before and after surgery. Patients with diabetes will also undergo perioperative oral glucose tolerance and endocrinological hormone tests. Hypertensive patients will also undergo perioperative echocardiography and carotid Doppler ultrasonography. Female patients suspected of having polycystic ovarian syndrome will also undergo perioperative hormone tests and abdominal ultrasonography. Visceral and subcutaneous fat will be harvested during surgery. Blood, stool and urine samples will be taken at various perioperative time points. Although the cohort is small and the follow-up duration is relatively short, this study will determine whether bariatric surgery induces satisfactory weight loss in obese Koreans. Significantly, the tissue samples will also facilitate many studies examining the effects of bariatric surgery and their mechanisms. Ethics and dissemination Ethics approval was obtained from the institutional review board of each participating hospital. All findings arising from this cohort study will be published in open-access peer-reviewed journals and will be presented at national and international meetings. All KOBESS investigators will be able to propose research studies and potential publications based on KOBESS data and tissue samples. Trial registration number NCT03100292; Pre-results.

Original languageEnglish
Article numbere018044
JournalBMJ Open
Volume7
Issue number10
DOIs
StatePublished - 2017 Oct 1

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Bariatric Surgery
Gastric Bypass
Gastrectomy
Clinical Protocols
Multicenter Studies
Cohort Studies
Obesity
Ethics
Weight Loss
Hormones
Doppler Ultrasonography
Anthropometry
Body Weight Changes
Intra-Abdominal Fat
Polysomnography
Polycystic Ovary Syndrome
Research Ethics Committees
Subcutaneous Fat
Waist Circumference
Korea

Keywords

  • korea
  • morbid obesity
  • roux-en-y gastric bypass
  • sleeve gastrectomy

Cite this

Park, Young Suk ; Park, Do Joong ; Lee, Joo Ho ; Lee, Hyuk Joon ; Ha, Tae Kyung ; Kim, Yong Jin ; Ryu, Seung Wan ; Han, Sang Moon ; Yoo, Moon Won ; Park, Sungsoo ; Han, Sang Uk ; Heo, Yoonseok. / Korean OBEsity Surgical Treatment Study (KOBESS) : Protocol of a prospective multicentre cohort study on obese patients undergoing laparoscopic sleeve gastrectomy and Roux-en-Y gastric bypass. In: BMJ Open. 2017 ; Vol. 7, No. 10.
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abstract = "Introduction Bariatric surgery effectively induces long-term weight loss in Western populations. However, its effectiveness in Asians remains to be confirmed objectively. The Korean Society for Metabolic and Bariatric Surgery proposes the first prospective cohort study on Koreans undergoing bariatric surgery. Methods and analysis The Korean OBEsity Surgical treatment Study (KOBESS) is a prospective, multicentre, single-arm, observational, cohort study on morbidly obese patients who undergo primary sleeve gastrectomy or Roux-en-Y gastric bypass in Korea. In total, 100 consecutive obese Asian patients who will undergo bariatric surgery will be recruited in 2016-2017; follow-up will be for 1 year. Primary outcomes are change in body weight and waist circumference at 1 year. All patients will undergo anthropometry, laboratory tests, bioelectrical impedance analysis, gastrofibroscopy, polysomnography and fat-measuring CT before and after surgery. Patients with diabetes will also undergo perioperative oral glucose tolerance and endocrinological hormone tests. Hypertensive patients will also undergo perioperative echocardiography and carotid Doppler ultrasonography. Female patients suspected of having polycystic ovarian syndrome will also undergo perioperative hormone tests and abdominal ultrasonography. Visceral and subcutaneous fat will be harvested during surgery. Blood, stool and urine samples will be taken at various perioperative time points. Although the cohort is small and the follow-up duration is relatively short, this study will determine whether bariatric surgery induces satisfactory weight loss in obese Koreans. Significantly, the tissue samples will also facilitate many studies examining the effects of bariatric surgery and their mechanisms. Ethics and dissemination Ethics approval was obtained from the institutional review board of each participating hospital. All findings arising from this cohort study will be published in open-access peer-reviewed journals and will be presented at national and international meetings. All KOBESS investigators will be able to propose research studies and potential publications based on KOBESS data and tissue samples. Trial registration number NCT03100292; Pre-results.",
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Korean OBEsity Surgical Treatment Study (KOBESS) : Protocol of a prospective multicentre cohort study on obese patients undergoing laparoscopic sleeve gastrectomy and Roux-en-Y gastric bypass. / Park, Young Suk; Park, Do Joong; Lee, Joo Ho; Lee, Hyuk Joon; Ha, Tae Kyung; Kim, Yong Jin; Ryu, Seung Wan; Han, Sang Moon; Yoo, Moon Won; Park, Sungsoo; Han, Sang Uk; Heo, Yoonseok.

In: BMJ Open, Vol. 7, No. 10, e018044, 01.10.2017.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Korean OBEsity Surgical Treatment Study (KOBESS)

T2 - Protocol of a prospective multicentre cohort study on obese patients undergoing laparoscopic sleeve gastrectomy and Roux-en-Y gastric bypass

AU - Park, Young Suk

AU - Park, Do Joong

AU - Lee, Joo Ho

AU - Lee, Hyuk Joon

AU - Ha, Tae Kyung

AU - Kim, Yong Jin

AU - Ryu, Seung Wan

AU - Han, Sang Moon

AU - Yoo, Moon Won

AU - Park, Sungsoo

AU - Han, Sang Uk

AU - Heo, Yoonseok

PY - 2017/10/1

Y1 - 2017/10/1

N2 - Introduction Bariatric surgery effectively induces long-term weight loss in Western populations. However, its effectiveness in Asians remains to be confirmed objectively. The Korean Society for Metabolic and Bariatric Surgery proposes the first prospective cohort study on Koreans undergoing bariatric surgery. Methods and analysis The Korean OBEsity Surgical treatment Study (KOBESS) is a prospective, multicentre, single-arm, observational, cohort study on morbidly obese patients who undergo primary sleeve gastrectomy or Roux-en-Y gastric bypass in Korea. In total, 100 consecutive obese Asian patients who will undergo bariatric surgery will be recruited in 2016-2017; follow-up will be for 1 year. Primary outcomes are change in body weight and waist circumference at 1 year. All patients will undergo anthropometry, laboratory tests, bioelectrical impedance analysis, gastrofibroscopy, polysomnography and fat-measuring CT before and after surgery. Patients with diabetes will also undergo perioperative oral glucose tolerance and endocrinological hormone tests. Hypertensive patients will also undergo perioperative echocardiography and carotid Doppler ultrasonography. Female patients suspected of having polycystic ovarian syndrome will also undergo perioperative hormone tests and abdominal ultrasonography. Visceral and subcutaneous fat will be harvested during surgery. Blood, stool and urine samples will be taken at various perioperative time points. Although the cohort is small and the follow-up duration is relatively short, this study will determine whether bariatric surgery induces satisfactory weight loss in obese Koreans. Significantly, the tissue samples will also facilitate many studies examining the effects of bariatric surgery and their mechanisms. Ethics and dissemination Ethics approval was obtained from the institutional review board of each participating hospital. All findings arising from this cohort study will be published in open-access peer-reviewed journals and will be presented at national and international meetings. All KOBESS investigators will be able to propose research studies and potential publications based on KOBESS data and tissue samples. Trial registration number NCT03100292; Pre-results.

AB - Introduction Bariatric surgery effectively induces long-term weight loss in Western populations. However, its effectiveness in Asians remains to be confirmed objectively. The Korean Society for Metabolic and Bariatric Surgery proposes the first prospective cohort study on Koreans undergoing bariatric surgery. Methods and analysis The Korean OBEsity Surgical treatment Study (KOBESS) is a prospective, multicentre, single-arm, observational, cohort study on morbidly obese patients who undergo primary sleeve gastrectomy or Roux-en-Y gastric bypass in Korea. In total, 100 consecutive obese Asian patients who will undergo bariatric surgery will be recruited in 2016-2017; follow-up will be for 1 year. Primary outcomes are change in body weight and waist circumference at 1 year. All patients will undergo anthropometry, laboratory tests, bioelectrical impedance analysis, gastrofibroscopy, polysomnography and fat-measuring CT before and after surgery. Patients with diabetes will also undergo perioperative oral glucose tolerance and endocrinological hormone tests. Hypertensive patients will also undergo perioperative echocardiography and carotid Doppler ultrasonography. Female patients suspected of having polycystic ovarian syndrome will also undergo perioperative hormone tests and abdominal ultrasonography. Visceral and subcutaneous fat will be harvested during surgery. Blood, stool and urine samples will be taken at various perioperative time points. Although the cohort is small and the follow-up duration is relatively short, this study will determine whether bariatric surgery induces satisfactory weight loss in obese Koreans. Significantly, the tissue samples will also facilitate many studies examining the effects of bariatric surgery and their mechanisms. Ethics and dissemination Ethics approval was obtained from the institutional review board of each participating hospital. All findings arising from this cohort study will be published in open-access peer-reviewed journals and will be presented at national and international meetings. All KOBESS investigators will be able to propose research studies and potential publications based on KOBESS data and tissue samples. Trial registration number NCT03100292; Pre-results.

KW - korea

KW - morbid obesity

KW - roux-en-y gastric bypass

KW - sleeve gastrectomy

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