Indium-111-labeled leukocyte scintigraphy in hemodialysis access-site infection

C. J. Palestro, A. Vega, Chun Ki Kim, S. Vallabhajosula, S. J. Goldsmith

Research output: Contribution to journalArticle

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Abstract

Bacterial sepsis, a significant complication of chronic hemodialysis, is generally the result of infection at the vascular access site. We retrospectively reviewed the utility of indium-111-(111In) labeled autologous leukocyte scintigraphy in 26 patients (30 scans) with synthetic vascular grafts, on chronic hemodialysis, in whom hemodialysis access site infection was a diagnostic consideration. Leukocyte scintigraphy correctly identified all fifteen access-site infections; there was one false-positive study, for an overall sensitivity and specificity of 100% and 93%, respectively. Of particular significance is the fact that in nine (60%) of the fifteen access-site infections, physical examination was normal. Our data indicate that 111In-labeled leukocyte scintigraphy is a useful procedure for the diagnosis of hemodialysis access-site infection, and it is especially valuable when physical examination of the access site is normal.

Original languageEnglish
Pages (from-to)319-324
Number of pages6
JournalJournal of Nuclear Medicine
Volume31
Issue number3
StatePublished - 1990 Jan 1

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Indium
Radionuclide Imaging
Renal Dialysis
Leukocytes
Infection
Physical Examination
Blood Vessels
Sepsis
Transplants
Sensitivity and Specificity

Cite this

Palestro, C. J., Vega, A., Kim, C. K., Vallabhajosula, S., & Goldsmith, S. J. (1990). Indium-111-labeled leukocyte scintigraphy in hemodialysis access-site infection. Journal of Nuclear Medicine, 31(3), 319-324.
Palestro, C. J. ; Vega, A. ; Kim, Chun Ki ; Vallabhajosula, S. ; Goldsmith, S. J. / Indium-111-labeled leukocyte scintigraphy in hemodialysis access-site infection. In: Journal of Nuclear Medicine. 1990 ; Vol. 31, No. 3. pp. 319-324.
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Palestro, CJ, Vega, A, Kim, CK, Vallabhajosula, S & Goldsmith, SJ 1990, 'Indium-111-labeled leukocyte scintigraphy in hemodialysis access-site infection', Journal of Nuclear Medicine, vol. 31, no. 3, pp. 319-324.

Indium-111-labeled leukocyte scintigraphy in hemodialysis access-site infection. / Palestro, C. J.; Vega, A.; Kim, Chun Ki; Vallabhajosula, S.; Goldsmith, S. J.

In: Journal of Nuclear Medicine, Vol. 31, No. 3, 01.01.1990, p. 319-324.

Research output: Contribution to journalArticle

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T1 - Indium-111-labeled leukocyte scintigraphy in hemodialysis access-site infection

AU - Palestro, C. J.

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N2 - Bacterial sepsis, a significant complication of chronic hemodialysis, is generally the result of infection at the vascular access site. We retrospectively reviewed the utility of indium-111-(111In) labeled autologous leukocyte scintigraphy in 26 patients (30 scans) with synthetic vascular grafts, on chronic hemodialysis, in whom hemodialysis access site infection was a diagnostic consideration. Leukocyte scintigraphy correctly identified all fifteen access-site infections; there was one false-positive study, for an overall sensitivity and specificity of 100% and 93%, respectively. Of particular significance is the fact that in nine (60%) of the fifteen access-site infections, physical examination was normal. Our data indicate that 111In-labeled leukocyte scintigraphy is a useful procedure for the diagnosis of hemodialysis access-site infection, and it is especially valuable when physical examination of the access site is normal.

AB - Bacterial sepsis, a significant complication of chronic hemodialysis, is generally the result of infection at the vascular access site. We retrospectively reviewed the utility of indium-111-(111In) labeled autologous leukocyte scintigraphy in 26 patients (30 scans) with synthetic vascular grafts, on chronic hemodialysis, in whom hemodialysis access site infection was a diagnostic consideration. Leukocyte scintigraphy correctly identified all fifteen access-site infections; there was one false-positive study, for an overall sensitivity and specificity of 100% and 93%, respectively. Of particular significance is the fact that in nine (60%) of the fifteen access-site infections, physical examination was normal. Our data indicate that 111In-labeled leukocyte scintigraphy is a useful procedure for the diagnosis of hemodialysis access-site infection, and it is especially valuable when physical examination of the access site is normal.

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Palestro CJ, Vega A, Kim CK, Vallabhajosula S, Goldsmith SJ. Indium-111-labeled leukocyte scintigraphy in hemodialysis access-site infection. Journal of Nuclear Medicine. 1990 Jan 1;31(3):319-324.