Improvement of differentiation and mineralization of pre-osteoblasts on composite nanofibers of poly(lactic acid) and nanosized bovine bone powder

Eun Kyoung Ko, Sung In Jeong, Ji Hye Lee, Heungsoo Shin

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The effect of NBM incorporation in PLA nanofibers on their mechanical properties and the differentiation and mineralization of osteoblasts was studied. At 20% NBM, the Young's modulus of the nanofibers was 37.78±4.23, significantly larger than that of pure PLA nanofibers. MC3T3-E1 pre-osteoblasts attached to both types of nanofibers and developed full osteogenic phenotypes. A profound effect of NBM on the mineralization of MCM-E1 pre-osteoblasts was confirmed, suggesting that NBM/PLA composite nanofibers exhibit properties similar to those of the native collagen-rich mineralized bone matrix, and could therefore serve as a temporary substrate for facilitating the differentiation and mineralization of bone-forming cells. A figure is presented.

Original languageEnglish
Pages (from-to)1098-1107
Number of pages10
JournalMacromolecular Bioscience
Volume8
Issue number12
DOIs
StatePublished - 2008 Dec 8

Fingerprint

Nanofibers
Osteoblasts
Lactic acid
Powders
Bone
Bone and Bones
Composite materials
Physiologic Calcification
Bone Matrix
Elastic Modulus
Multicarrier modulation
Collagen
Elastic moduli
poly(lactic acid)
Phenotype
Mechanical properties
Substrates

Keywords

  • Biodegradable
  • Composites
  • Fibers
  • Microstructure
  • Mineral

Cite this

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title = "Improvement of differentiation and mineralization of pre-osteoblasts on composite nanofibers of poly(lactic acid) and nanosized bovine bone powder",
abstract = "The effect of NBM incorporation in PLA nanofibers on their mechanical properties and the differentiation and mineralization of osteoblasts was studied. At 20{\%} NBM, the Young's modulus of the nanofibers was 37.78±4.23, significantly larger than that of pure PLA nanofibers. MC3T3-E1 pre-osteoblasts attached to both types of nanofibers and developed full osteogenic phenotypes. A profound effect of NBM on the mineralization of MCM-E1 pre-osteoblasts was confirmed, suggesting that NBM/PLA composite nanofibers exhibit properties similar to those of the native collagen-rich mineralized bone matrix, and could therefore serve as a temporary substrate for facilitating the differentiation and mineralization of bone-forming cells. A figure is presented.",
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Improvement of differentiation and mineralization of pre-osteoblasts on composite nanofibers of poly(lactic acid) and nanosized bovine bone powder. / Ko, Eun Kyoung; Jeong, Sung In; Lee, Ji Hye; Shin, Heungsoo.

In: Macromolecular Bioscience, Vol. 8, No. 12, 08.12.2008, p. 1098-1107.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Improvement of differentiation and mineralization of pre-osteoblasts on composite nanofibers of poly(lactic acid) and nanosized bovine bone powder

AU - Ko, Eun Kyoung

AU - Jeong, Sung In

AU - Lee, Ji Hye

AU - Shin, Heungsoo

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AB - The effect of NBM incorporation in PLA nanofibers on their mechanical properties and the differentiation and mineralization of osteoblasts was studied. At 20% NBM, the Young's modulus of the nanofibers was 37.78±4.23, significantly larger than that of pure PLA nanofibers. MC3T3-E1 pre-osteoblasts attached to both types of nanofibers and developed full osteogenic phenotypes. A profound effect of NBM on the mineralization of MCM-E1 pre-osteoblasts was confirmed, suggesting that NBM/PLA composite nanofibers exhibit properties similar to those of the native collagen-rich mineralized bone matrix, and could therefore serve as a temporary substrate for facilitating the differentiation and mineralization of bone-forming cells. A figure is presented.

KW - Biodegradable

KW - Composites

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KW - Microstructure

KW - Mineral

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