IL-4 signaling, gene transcription regulation, and the control of effector T cells

M. Boothby, A. L. Mora, M. A. Aronica, Jeehee Youn, J. R. Sheller, S. Goenka, L. Stephenson

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

The central goal of our laboratory is to understand the regulation of lymphoid cells through molecular mechanisms of signal transduction and transcriptional control. A long-standing focus has been on changes that influence the effector function of mature lymphocytes. Work in the laboratory is oriented toward the identification of new regulatory mechanisms using cell lines and primary cells, and the validation of these in vitro findings in mouse models of immune responses and diseases. In this review, we summarize key insights into the regulation of T helper cell function during the phase of immunity where effector responses arise de novo. Particular interest has been centered on cytokine gene regulation as part of T cell differentiation into the Th1 and Th2 subsets. Information on IL-4 receptor signaling and the role of NF-κB transcription factors is reviewed. Our more recent work is designed to understand how regulation at the Th1/2 effector stages is related to the control of memory T cell survival, immune recall responses, and the role of these responses in immune-mediated disease.

Original languageEnglish
Pages (from-to)179-191
Number of pages13
JournalImmunologic Research
Volume23
Issue number2-3
DOIs
StatePublished - 2001 Jan 1

Fingerprint

Immune System Diseases
Interleukin-4
Interleukin-4 Receptors
Lymphocytes
T-Lymphocytes
Helper-Inducer T-Lymphocytes
Genes
Cell Differentiation
Immunity
Signal Transduction
Cell Survival
Transcription Factors
Cytokines
Cell Line
In Vitro Techniques
3'-(1-butylphosphoryl)adenosine

Keywords

  • Asthma
  • Gene Regulation
  • IL-4
  • Memory
  • Mouse Models
  • NF-kappa
  • Th1
  • Th2

Cite this

Boothby, M., Mora, A. L., Aronica, M. A., Youn, J., Sheller, J. R., Goenka, S., & Stephenson, L. (2001). IL-4 signaling, gene transcription regulation, and the control of effector T cells. Immunologic Research, 23(2-3), 179-191. https://doi.org/10.1385/IR:23:2-3:179
Boothby, M. ; Mora, A. L. ; Aronica, M. A. ; Youn, Jeehee ; Sheller, J. R. ; Goenka, S. ; Stephenson, L. / IL-4 signaling, gene transcription regulation, and the control of effector T cells. In: Immunologic Research. 2001 ; Vol. 23, No. 2-3. pp. 179-191.
@article{7bbd141b623b42d09e03b0811aa8df57,
title = "IL-4 signaling, gene transcription regulation, and the control of effector T cells",
abstract = "The central goal of our laboratory is to understand the regulation of lymphoid cells through molecular mechanisms of signal transduction and transcriptional control. A long-standing focus has been on changes that influence the effector function of mature lymphocytes. Work in the laboratory is oriented toward the identification of new regulatory mechanisms using cell lines and primary cells, and the validation of these in vitro findings in mouse models of immune responses and diseases. In this review, we summarize key insights into the regulation of T helper cell function during the phase of immunity where effector responses arise de novo. Particular interest has been centered on cytokine gene regulation as part of T cell differentiation into the Th1 and Th2 subsets. Information on IL-4 receptor signaling and the role of NF-κB transcription factors is reviewed. Our more recent work is designed to understand how regulation at the Th1/2 effector stages is related to the control of memory T cell survival, immune recall responses, and the role of these responses in immune-mediated disease.",
keywords = "Asthma, Gene Regulation, IL-4, Memory, Mouse Models, NF-kappa, Th1, Th2",
author = "M. Boothby and Mora, {A. L.} and Aronica, {M. A.} and Jeehee Youn and Sheller, {J. R.} and S. Goenka and L. Stephenson",
year = "2001",
month = "1",
day = "1",
doi = "10.1385/IR:23:2-3:179",
language = "English",
volume = "23",
pages = "179--191",
journal = "Immunologic Research",
issn = "0257-277X",
number = "2-3",

}

Boothby, M, Mora, AL, Aronica, MA, Youn, J, Sheller, JR, Goenka, S & Stephenson, L 2001, 'IL-4 signaling, gene transcription regulation, and the control of effector T cells', Immunologic Research, vol. 23, no. 2-3, pp. 179-191. https://doi.org/10.1385/IR:23:2-3:179

IL-4 signaling, gene transcription regulation, and the control of effector T cells. / Boothby, M.; Mora, A. L.; Aronica, M. A.; Youn, Jeehee; Sheller, J. R.; Goenka, S.; Stephenson, L.

In: Immunologic Research, Vol. 23, No. 2-3, 01.01.2001, p. 179-191.

Research output: Contribution to journalArticle

TY - JOUR

T1 - IL-4 signaling, gene transcription regulation, and the control of effector T cells

AU - Boothby, M.

AU - Mora, A. L.

AU - Aronica, M. A.

AU - Youn, Jeehee

AU - Sheller, J. R.

AU - Goenka, S.

AU - Stephenson, L.

PY - 2001/1/1

Y1 - 2001/1/1

N2 - The central goal of our laboratory is to understand the regulation of lymphoid cells through molecular mechanisms of signal transduction and transcriptional control. A long-standing focus has been on changes that influence the effector function of mature lymphocytes. Work in the laboratory is oriented toward the identification of new regulatory mechanisms using cell lines and primary cells, and the validation of these in vitro findings in mouse models of immune responses and diseases. In this review, we summarize key insights into the regulation of T helper cell function during the phase of immunity where effector responses arise de novo. Particular interest has been centered on cytokine gene regulation as part of T cell differentiation into the Th1 and Th2 subsets. Information on IL-4 receptor signaling and the role of NF-κB transcription factors is reviewed. Our more recent work is designed to understand how regulation at the Th1/2 effector stages is related to the control of memory T cell survival, immune recall responses, and the role of these responses in immune-mediated disease.

AB - The central goal of our laboratory is to understand the regulation of lymphoid cells through molecular mechanisms of signal transduction and transcriptional control. A long-standing focus has been on changes that influence the effector function of mature lymphocytes. Work in the laboratory is oriented toward the identification of new regulatory mechanisms using cell lines and primary cells, and the validation of these in vitro findings in mouse models of immune responses and diseases. In this review, we summarize key insights into the regulation of T helper cell function during the phase of immunity where effector responses arise de novo. Particular interest has been centered on cytokine gene regulation as part of T cell differentiation into the Th1 and Th2 subsets. Information on IL-4 receptor signaling and the role of NF-κB transcription factors is reviewed. Our more recent work is designed to understand how regulation at the Th1/2 effector stages is related to the control of memory T cell survival, immune recall responses, and the role of these responses in immune-mediated disease.

KW - Asthma

KW - Gene Regulation

KW - IL-4

KW - Memory

KW - Mouse Models

KW - NF-kappa

KW - Th1

KW - Th2

UR - http://www.scopus.com/inward/record.url?scp=0034989395&partnerID=8YFLogxK

U2 - 10.1385/IR:23:2-3:179

DO - 10.1385/IR:23:2-3:179

M3 - Article

C2 - 11444383

AN - SCOPUS:0034989395

VL - 23

SP - 179

EP - 191

JO - Immunologic Research

JF - Immunologic Research

SN - 0257-277X

IS - 2-3

ER -