Hypocholestrolemic effect of CJ90002 in hamsters: A potent inhibitor for squalene synthase from Paeonia moutan

Jong Koo Park, Hi Jae Cho, Yoongho Lim, Youl Hee Cho, Chul Hoon Lee

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Squalene synthase catalyzes the reductive dimerization of two molecules of farnesyl diphosphate to form squalene at the final branch point of the cholesterol biosynthetic pathway. Due to the unique position of this enzyme in the pathway, its inhibitors may have advantages as antihypercholesterolemic agents. Therefore, selective inhibitors of squalene synthase do not prevent the formation of the essential branch products of the isoprene pathway, such as dolichol, coenzyme-Q, and prenylated proteins, as might be expected for inhibitors of enzymes earlier in the pathway; for example, lovastatin and mevalotin. The current study reports that CJ90002, a pentagalloylglucose isolated from Paeonia moutan SIM (Paeoniaceae), which is an important Chinese crude drug used in many traditional prescriptions, was a potent inhibitor of rat microsomal squalene synthase, and also a potent inhibitor of cholesterol biosynthesis in vitro. In addition, the intraperitoneal and oral administration of CJ90002 had a significant lowering effect on plasma cholesterol levels in hamsters.

Original languageEnglish
Pages (from-to)222-227
Number of pages6
JournalJournal of Microbiology and Biotechnology
Volume12
Issue number2
StatePublished - 2002 Jan 1

Keywords

  • Cholesterol lowering agent
  • Paeonia moutan
  • Pentagalloylglucose
  • Squalene synthase

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