Human prothrombin fragment 1 and 2 inhibit bFGF-induced BCE cell growth

Taiyoun Rhim, Chan Soo Park, Eunkyung Kim, Soung Soo Kim

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Previously, we reported that the rabbit prothrombin fragment 2 (kringle 2 domain) has an anti-endothelial cell proliferative effect. In this report, we show that not only rabbit prothrombin fragment 2 but also human prothrombin fragment 1 and 2 have an inhibitory effect on bFGF-stimulated BCE cell growth. Human prothrombin fragment 1 and 2 obtained as proteolytic fragments of human prothrombin display potent inhibitory effects on bovine capillary endothelial cells with a half-maximal concentration (ED50) of approximately 100 nM and 120 nM, respectively. As rabbit prothrombin fragment 2, the human prothrombin fragment 1 and 2 also inhibit angiogenesis in the chorioallantoic membrane (CAM) of chick embryos.

Original languageEnglish
Pages (from-to)513-516
Number of pages4
JournalBiochemical and Biophysical Research Communications
Volume252
Issue number2
DOIs
StatePublished - 1998 Nov 18

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Cell growth
Growth
Endothelial cells
Rabbits
Endothelial Cells
Kringles
Chorioallantoic Membrane
Prothrombin
Chick Embryo
prothrombin fragment 2
prothrombin fragment 1
Membranes

Cite this

Rhim, Taiyoun ; Park, Chan Soo ; Kim, Eunkyung ; Kim, Soung Soo. / Human prothrombin fragment 1 and 2 inhibit bFGF-induced BCE cell growth. In: Biochemical and Biophysical Research Communications. 1998 ; Vol. 252, No. 2. pp. 513-516.
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Human prothrombin fragment 1 and 2 inhibit bFGF-induced BCE cell growth. / Rhim, Taiyoun; Park, Chan Soo; Kim, Eunkyung; Kim, Soung Soo.

In: Biochemical and Biophysical Research Communications, Vol. 252, No. 2, 18.11.1998, p. 513-516.

Research output: Contribution to journalArticle

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