Hepatoid adenocarcinoma of the gallbladder with production of alpha-fetoprotein

Jae Hoon Lee, Kyeong Geun Lee, Seung Sam Paik, Hwon Kyum Park, Kwang Soo Lee

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Hepatoid adenocarcinoma (HAC) is a tumor with aberrant hepatocellular differentiation that occurs in extrahepatic organs. HAC of the gallbladder is rare, and cases of alpha-fetoprotein production are extremely rare. A 61-year-old man was diagnosed with gallbladder adenocarcinoma after laparoscopic cholecystectomy. A radical operation including resection of liver bed and lymph node dissection was performed, and no tumor cell was found. However, at postoperative 19 months, he showed lymphadenopathy of the portocaval area and tumor thrombi in the right portal vein with high levels of serum alpha-fetoprotein. After right hemihepatectomy and portahepatis lymph node dissection was performed, he was diagnosed with metastatic HAC. On reviewing the gallbladder specimen, the tumor finally demonstrated HAC as the primary origin. Despite adjuvant therapy, the patient died from multiple liver metastasis 26 months after cholecystectomy. Although HAC of the gallbladder is a very rare malignancy, awareness of its existence is critical to avoid misdiagnosis.

Original languageEnglish
Pages (from-to)440-444
Number of pages5
JournalJournal of the Korean Surgical Society
Volume80
Issue number6
DOIs
StatePublished - 2011 Jun 1

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alpha-Fetoproteins
Gallbladder
Adenocarcinoma
Neoplasms
Lymph Node Excision
Laparoscopic Cholecystectomy
Liver
Cholecystectomy
Portal Vein
Diagnostic Errors
Thrombosis
Neoplasm Metastasis
Serum

Keywords

  • Alpha-fetoprotein
  • Gallbladder
  • Hepatoid adenocarcinoma

Cite this

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title = "Hepatoid adenocarcinoma of the gallbladder with production of alpha-fetoprotein",
abstract = "Hepatoid adenocarcinoma (HAC) is a tumor with aberrant hepatocellular differentiation that occurs in extrahepatic organs. HAC of the gallbladder is rare, and cases of alpha-fetoprotein production are extremely rare. A 61-year-old man was diagnosed with gallbladder adenocarcinoma after laparoscopic cholecystectomy. A radical operation including resection of liver bed and lymph node dissection was performed, and no tumor cell was found. However, at postoperative 19 months, he showed lymphadenopathy of the portocaval area and tumor thrombi in the right portal vein with high levels of serum alpha-fetoprotein. After right hemihepatectomy and portahepatis lymph node dissection was performed, he was diagnosed with metastatic HAC. On reviewing the gallbladder specimen, the tumor finally demonstrated HAC as the primary origin. Despite adjuvant therapy, the patient died from multiple liver metastasis 26 months after cholecystectomy. Although HAC of the gallbladder is a very rare malignancy, awareness of its existence is critical to avoid misdiagnosis.",
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Hepatoid adenocarcinoma of the gallbladder with production of alpha-fetoprotein. / Lee, Jae Hoon; Lee, Kyeong Geun; Paik, Seung Sam; Park, Hwon Kyum; Lee, Kwang Soo.

In: Journal of the Korean Surgical Society, Vol. 80, No. 6, 01.06.2011, p. 440-444.

Research output: Contribution to journalArticle

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AB - Hepatoid adenocarcinoma (HAC) is a tumor with aberrant hepatocellular differentiation that occurs in extrahepatic organs. HAC of the gallbladder is rare, and cases of alpha-fetoprotein production are extremely rare. A 61-year-old man was diagnosed with gallbladder adenocarcinoma after laparoscopic cholecystectomy. A radical operation including resection of liver bed and lymph node dissection was performed, and no tumor cell was found. However, at postoperative 19 months, he showed lymphadenopathy of the portocaval area and tumor thrombi in the right portal vein with high levels of serum alpha-fetoprotein. After right hemihepatectomy and portahepatis lymph node dissection was performed, he was diagnosed with metastatic HAC. On reviewing the gallbladder specimen, the tumor finally demonstrated HAC as the primary origin. Despite adjuvant therapy, the patient died from multiple liver metastasis 26 months after cholecystectomy. Although HAC of the gallbladder is a very rare malignancy, awareness of its existence is critical to avoid misdiagnosis.

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