Gamma electron vertex imaging and application to beam range verification in proton therapy

Chan Hyeong Kim, Jin Hyung Park, Hee Seo, Han Rim Lee

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Purpose: This paper describes a new gamma-ray imaging method, gamma electron vertex imaging (GEVI), which can be used for precise beam range verification in proton therapy. Methods: In GEVI imaging, the high-energy gammas from a source or nuclear interactions are first converted, by Compton scattering, to electrons, which subsequently are traced by hodoscopes to determine the location of the gamma source or the vertices of the nuclear interactions. The performance of GEVI imaging for use in-beam range verification was evaluated by Monte Carlo simulations employing geant4 equipped with the QGSP-BIC-HP physics package. Results: Our simulation results show that GEVI imaging can determine the proton beam range very accurately, within 2-3 mm of error, even without any sophisticated analysis. The results were obtained under simplified conditions of monoenergetic pencil beams stopped in a homogeneous phantom and on the basis of the obtained results it is expected to achieve submillimeter accuracy in proton beam range measurement. Conclusions: If future experimental work confirms the simulated results presented in this paper, the use of GEVI imaging is expected to have a great potential in increasing the accuracy of proton beam range verification in a patient, resulting in significant improvement of treatment effectiveness by enabling tight conformation of radiation dose to the tumor volume and patient safety.

Original languageEnglish
Pages (from-to)1001-1005
Number of pages5
JournalMedical Physics
Volume39
Issue number2
DOIs
StatePublished - 2012 Jan 1

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Proton Therapy
Electrons
Protons
imidazole mustard
Gamma Rays
Physics
Patient Safety
Tumor Burden
Radiation

Keywords

  • gamma electron vertex imaging
  • prompt gamma
  • proton therapy
  • range verification

Cite this

Kim, Chan Hyeong ; Hyung Park, Jin ; Seo, Hee ; Rim Lee, Han. / Gamma electron vertex imaging and application to beam range verification in proton therapy. In: Medical Physics. 2012 ; Vol. 39, No. 2. pp. 1001-1005.
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Gamma electron vertex imaging and application to beam range verification in proton therapy. / Kim, Chan Hyeong; Hyung Park, Jin; Seo, Hee; Rim Lee, Han.

In: Medical Physics, Vol. 39, No. 2, 01.01.2012, p. 1001-1005.

Research output: Contribution to journalArticle

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